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Weight stigma negatively impacts people with higher weights across the lifespan as well as social contexts and can lead to weight discrimination. As weight is not a protected identity in Canadian human rights legislation, it is important to better understand how weight discrimination is being argued in Canada’s legal system. The purpose of this environmental scan was to examine and describe Canadi
Background: Obesity is a chronic disease linked to over 200 health conditions, reduced quality of life, and increased mortality. Despite the availability of multimodal treatments, there is a lack of standardised, patient-centred outcome measures to effectively assess and improve clinical care. This project aimed to define a core set of standardised outcome measures for adults with obesity, incorpo
BACKGROUND: Patients perceive high levels of weight prejudice, stigma, and discrimination within health systems, affecting their ability to manage their obesity and related chronic conditions. Scientific and patient obesity associations worldwide have prioritized the reduction of weight stigma to improve patient experiences in health systems and overall health outcomes. Since a significant proport
The lack of standardization in patient-reported outcome measures (PROMs) has made measurement and comparison of quality of life (QoL) outcomes in research focused on obesity treatment challenging. This study reports on the results of the second and third global multidisciplinary Standardizing Quality of life measures in Obesity Treatment (S.Q.O.T.) consensus meetings, where a core set of PROMs to
PURPOSE: The focus of measuring success in obesity treatment is shifting from weight loss to patients' health and quality of life. The objective of this study was to select a core set of patient-reported outcomes and patient-reported outcome measures to be used in clinical obesity care.MATERIALS AND METHODS: The Standardizing Quality of Life in Obesity Treatment III, face-to-face hybrid consensus
Intro: Population-based studies predominantly focused on carcinoma of the parotid gland (CPG) are rare. The study aims were to analyze the incidence of CPG and to assess treatment outcomes in relation to histopathology, preoperative diagnosis and adjuvant radiotherapy. Methods: A retrospective analysis was conducted on data from the Swedish Head and Neck Cancer Register (SweHNCR), including 1,018
PURPOSE: To develop Mexico's first methodologically rigorous clinical practice guideline for the management of adult overweight and obesity. The target audiences are interdisciplinary healthcare professionals across healthcare systems who are the first point of contact for patients with obesity in Mexico, patients, and health system decision makers.RECENT FINDINGS: A review of recent international
BACKGROUND: An international panel of obesity medicine experts from multiple professional organizations examined patterns of obesity care and current obesity treatment guidelines to identify areas requiring updating in response to emerging science and clinical evidence.AIMS: The panel focused on multiple medical health and societal issues influencing effective treatment of obesity and identified s
Shared e-scooters (SEs) are increasingly integrated into urban mobility systems, yet their role in commuting and contribution to sustainable transport remain insufficiently understood. This study examines SE commuting patterns in Malmo, Sweden, focusing on their use as both a first-/last-mile connection to public transport and a primary commuting mode. Using pre-pandemic trip data from a major SE
Weight bias is a social justice issue that manifests in social and health inequities, affecting the lives of millions of individuals globally. Although weight bias research has increased over the last two decades, it remains pervasive, and more work is needed to establish effective strategies to reduce it. The 2024 International Weight Bias Summit aimed to collaboratively identify future research
Background Prothrombin is a vitamin K-dependent glycoprotein synthesized in the liver and circulating in blood as an inactive zymogen. The corresponding activated thrombin enzyme is a central player in hemostasis and thrombosis. Still, little is known about the individual variation over time of the prothrombin concentration in plasma in the general population. Objectives This study aimed to establ
Objective: Investigate the role of metabolic syndrome and obesity in incident osteoarthritis (OA). Methods: Prospective cohort study with up to 11 years follow-up. From a general population cohort of 28,786 individuals from Sweden aged 45 to 75, we selected individuals without OA diagnosis and without joint pain during the year prior to the baseline. Metabolic syndrome was defined at baseline by t
The use of remote sensing and reanalysis weather data has not been adequately acknowledged for large-scale built environment applications, primarily regarding engineering analyses that traditionally rely on computationally expensive numerical models. This study employs a parsimonious data-driven approach concerning service life assessment of rain-exposed wooden components, enabling mapping and ass
Background: Pancreatic ductal adenocarcinoma (PDAC) is characterized by a prominent desmoplastic stroma, which plays a crucial role in tumor biology and treatment resistance. While the stromal compartment is a defining histopathological feature of PDAC, its prognostic significance remains incompletely understood. This study aimed to quantify the stromal content in PDAC using digital pathology and
The bladder trigone is a distinct anatomical and functional subregion of the urinary bladder, defined by its triangular configuration between the ureteral orifices and the internal urethral orifice. Although traditionally less studied compared to the bladder dome and detrusor body, recent morphological, molecular, and transcriptomic analyses reveal that the trigone is highly specialized. Understan
Understanding greenhouse gas fluxes in semi-arid ecosystems is critical for improving our understanding of biogeochemical cycles, particularly in underrepresented regions like the African Sahel. In these landscapes, greenhouse gas exchange arises from ground, trees, and water ponds, and is further shaped by environmental conditions and grazing. The carbon dioxide, methane, and nitrous oxide fluxes
Leigh syndrome is a fatal pediatric neurodegenerative disease caused by mitochondrial dysfunction, which can be modeled in the Ndufs4 KO mouse with mitochondrial respiratory chain complex I (CI) deficiency. This study explores NV354, a prodrug of succinate with enhanced oral bioavailability and brain uptake, as a potential therapy to counteract this devastating condition. NV354 modulated whole-bod
