Several sources of DNA damage compromise the integrity and stability of the genome of every organism. Specifically, DNA double-strand breaks (DSBs) can have lethal consequences for the cell. To repair this type of DNA damage, the cells employ homology-directed repair pathways or non-homologous end joining. Homology-directed repair requires the activity of the RAD52 epistasis group of genes. Rad52

This study investigates the effect of different mixers and the applicability of the mixing energy (ME) concept to dry powder formulations for inhalation. With the aim to step-wise build and expand this concept, adhesive mixtures of 2 % budesonide and lactose carrier were investigated, both with 1 % magnesium stearate (MgSt) added in a ‘coating’ step, and without, the latter referred to as ‘naked’

The concept of ‘sustainable welfare’ conceptualizes welfare and wellbeing within planetary limits. Yet there is a lack of knowledge about possible social and political carriers of corresponding social-ecological transformations. For the promotion of the changes of societal core institutions that climate scientists deem necessary in the nearer future knowledge of which parts of the population are m

Despite the well-documented effectiveness of metabolic and bariatric surgery (MBS) in treating severe obesity, significant gaps persist in understanding adolescents' lived experiences and perspectives. Addressing these gaps is essential for enhancing patient-centered care and supporting long-term outcomes.

BACKGROUND: The MeToo-movement challenges the 'culture of silence' regarding sexual harassment (SH). There are few studies regarding this phenomenon in academic settings. The aim of this study was to investigate the relationship between having reported or disclosed SH, on the one hand, and background factors and general health and wellbeing of exposed individuals, types of SH and perpetrator chara

We present new abundance determinations of neutron-capture elements Ge, Zr, Os, Ir, and Pt in a sample of 11 metal-poor (-3.1

A well established notion in Buddhist literature is that meditation practice improves the ability to be mindful in daily life which in turn promotes psychological wellbeing. In order to test this hypothesis the relations between meditation experience, five mindfulness facets and psychological well-being were studied in a sample consisting of Buddhist meditators, Western mindfulness meditators and

Bacterial surface-associated plasmin formation is believed to contribute to invasion, although the underlying molecular mechanisms are poorly understood. To define the components necessary for plasmin generation on group A streptococci we used strain AP53 which exposes an M-like protein ("PAM") that contains a plasminogen-binding sequence with two 13-amino acid residues long tandem repeats (a1 and

The relationship between a physiological index called the photochemical reflectance index (PRI) and photosynthetic light-use-efficiency (LUE) of a Siberian boreal forest during the winter–spring transition, or green-up period, was investigated in 2000. During this time the photosynthetic apparatus was considered under stress as a result of extremes of temperature (from −20 to 35 °C) coupled with a

The usual practice to measure the zero sequence voltage on the D-side of a transformer is to use three voltage transformers (VT), each of them connected between each phase and earth on the primary side and broken-delta connected on the secondary side. In this paper a method is presented for the estimation of the zero sequence voltage on the D-side of a Dy transformer by the use of only one VT conn

Despite the environmental and health importance of tourist walking, specific research on walking and tourism is limited, with walking in leisure and work contexts often being used as a proxy. To fill this gap, this study identifies the effects of perception of air quality and mitigating climate change on attachment to walking relevant to walkable places and subjective well-being, along with compar

Linking clinical multi-omics with mechanistic studies may improve the understanding of rare cancers. We leverage two precision oncology programs to investigate rhabdomyosarcoma with FUS/EWSR1-TFCP2 fusions, an orphan malignancy without effective therapies. All tumors exhibit outlier ALK expression, partly accompanied by intragenic deletions and aberrant splicing resulting in ALK variants that are