Practices of care between grandparents, adult children and grandchildren are the hub of intergenerational relationships. To care for an elderly parent, or for a grandchild, is an engagement that can be a necessity coming out of lack of other care providers, or it can be an engagement you voluntarily take upon yourself. It can feel like an obligation, and/or as something you do out of love for your

Lymph nodes (LNs) are believed to be the first organs targeted by colorectal cancer cells detached from a primary solid tumor because of their role in draining interstitial fluids. Better detection and assessment of these organs have the potential to help clinicians in stratification and designing optimal design of oncological treatments for each patient. Whilst highly valuable for the detection o

Patient experience is defined as a major quality indicator that should be routinely measured during and after a colonoscopy, according to current ESGE guidelines. There is no standard approach measuring patient experience after the procedure and the comparative performance of the different colonoscopy-specific patient-reported experience measures (PREMs) is unclear. Therefore, the aim was to devel

Brain tissue segmentation plays a crucial role in feature extraction, volumetric quantification, and morphometric analysis of brain scans. For the assessment of brain structure and integrity, CT is a non-invasive, cheaper, faster, and more widely available modality than MRI. However, the clinical application of CT is mostly limited to the visual assessment of brain integrity and exclusion of copat

Background: The contribution of endothelial injury in the pathogenesis of COVID-19-associated acute respiratory distress syndrome (ARDS) and resulting respiratory failure remains unclear. Plasma endostatin, an endogenous inhibitor of angiogenesis and endothelial dysfunction is upregulated during hypoxia, inflammation and progress of pulmonary disease. Aim: To investigate if plasma endostatin is as

Enabling vehicles to draw energy from an electric road system (ERS) significantly reduces the need for battery capacity on board the vehicle. It is not necessary, nor realistic, to cover every meter of every stretch of road with ERS. The question then arises how and where the ERS sections should be placed. One way of doing it is to place equally long sections of ERS with a certain separating dista

Purpose: The purpose of this paper is to explore different types of packaging paradoxes and the reasons for their existence in food supply chains. Design/methodology/approach: The research uses a multiple case study approach with rich empirical data from seven leading companies in Swedish food supply chains. The research uses coding and a paradox theory lens to analyse packaging paradoxes, both wi

The increasing levels of software- and data-intensive driving automation call for an evolution of automotive soft-ware testing. As a recommended practice of the Verification and Validation (VV) process of ISO/PAS 21448, a candidate standard for safety of the intended functionality for road vehicles, simulation-based testing has the potential to reduce both risks and costs. There is a growing body

In this paper, we study the problem of error propagation in sliding window decoding (SWD) of spatially coupled LDPC (SC-LDPC) codes. A general decoder model that accounts for error propagation is proposed and analyzed, and the decoded block error rate (BLER) is calculated using the model. In order to improve the BLER performance under decoder error propagation conditions, adaptive variable node (V

The goal of this article is to examine the nature of interaction between the Georgian Orthodox Church (GOC) and the state during the pandemic. The article shows how the church’s gradual acknowledgement of the deadly character of the virus coincided with a strict adherence to certain highly risky religious practices (such as communion from the same spoon), while the Georgian government’s stance in

Miller syndrome is a rare Mendelian disorder caused by mutations in the gene encoding human dihydroorotate dehydrogenase (DHODH). Human DHODH, a Class II DHODH, is an integral protein of the inner mitochondrial membrane (IMM) catalyzing the fourth step of the de novo pyrimidine biosynthesis pathway. Here we present a summary of the state of knowledge regarding Miller syndrome in the absence of any

Human dihydroorotate dehydrogenase (DHODH) catalyzes the fourth step of the de novo pyrimidine biosynthesis pathway and uses ubiquinone Q10, a lipophilic molecule located in the inner mitochondrial membrane (IMM), as its co-substrate. DHODH is anchored to the IMM by a single transmembrane helix located at its N-terminus. Nevertheless, how DHODH function is determined by its surrounding membrane en