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Validity of ABCD Rule of Dermoscopy in Clinical Practice.

The ABCD rule of dermoscopy was developed to facilitate diagnosis in the dermoscopy of pigmented lesions. However, there is a lack of studies on its validity in clinical practice. The aim of this study was to evaluate the accuracy of the algorithm used bedside, compared with the accuracy of the preliminary preoperative diagnosis, and to rate physicians' level of confidence in the diagnosis. Melano

St. Birgitta, an Architect of Spiritual Reform

The shape and features of a typical abbey church of the Birgittine Order are studied, based on the stipulations laid down by St. Birgitta of Sweden herself. The architecture is interpreted as paradigmatic of the kind of spiritual reform that St. Birgitta aimed at.

Identification of Tyr-703 and Tyr-936 as the primary association sites for Grb2 and Grb7 in the c-Kit/stem cell factor receptor

In this paper we demonstrate the presence of two novel in vivo autophosphorylation sites in the c-Kit/stem cell factor receptor (c-Kit/SCFR): Tyr-703 in the kinase insert and Tyr-936 in the C-terminal tail. We furthermore demonstrate that the adapter protein Grb2 is a specific binding partner for both phosphorylated Tyr-703 and phosphorylated Tyr-936, whereas the adapter protein Grb7 binds selecti

Sick leave in patients with ankylosing spondylitis before and after anti-TNF therapy: a population-based cohort study.

Objective. To study levels of sick leave and disability pension before and after TNF-antagonist therapy in AS patients. Methods. Using the population-based South Swedish Arthritis Treatment Group register, we identified 139 AS patients (aged 18-58 years, 78% men), who between January 2002 and December 2008 started their first treatment with adalimumab, etanercept or infliximab. We linked data to t

A numerical integrator for simulation of unstructured implicit models

Object oriented modeling naturally leads to implicitly defined dynamical systems or, as they are also called, differential algebraic equations (DAEs). Most existing DAE integrators require the equations defining the dynamical system to have a special structure. Progress on the development of a new integrator for general unstructured DAEs is presented. The new integrator is called UCP. Computationa

Clinical isolates of Streptococcus pneumoniae bind the complement inhibitor C4b-binding protein in a PspC allele-dependent fashion.

The complement system constitutes an important component of the innate immune system. To colonize their host and/or to cause disease, many pathogens have evolved strategies to avoid complement-mediated bacterial lysis and opsonophagocytosis. In this study, using a collection of 55 clinical isolates of Streptococcus pneumoniae, we demonstrate for the first time that pneumococci bind the complement

Sports and Leisure Time Physical Activity During Pregnancy in Nulliparous Women.

To describe patterns of leisure time physical activity during pregnancy in relation to pre-pregnancy leisure time physical activity, socio-demographic characteristics, fertility history, and lifestyle factors. 4,718 nulliparous with singleton pregnancy and intended spontaneous vaginal delivery were included in the study at gestational week 33 from May 2004 to July 2005. Information was provided by