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Survival for patients diagnosed with mantle cell lymphoma (MCL) has improved drastically in recent years. However, patients carrying mutations in tumour protein p53 (TP53) do not benefit from modern chemotherapy-based treatments and have poor prognosis. Thus, there is a clinical need to identify missense mutations through routine analysis to enable patient stratification. Sequencing is not widely
In the last 40 years, leadership studies (LS) have moved from a condition of near despair, where complaints of slow progress were commonplace, to a situation of self-confidence and self-praise. However, during recent years we have seen an upsurge in criticism alongside a contradiction between positive leadership ideas and a working life bearing little imprint of the upbeat messages said to charact
Zeolites are widely used in catalysis, gas separation, ion exchange, etc. due to their superior physicochemical properties, which are closely related to specific features of their framework structures. Although more than two hundred different framework types have been recognized, it is of great interest to explore from a crystallographic perspective, the atomic positions, surface terminations, por
Objective: To develop a model and methodology for predicting the risk of Gleason upgrading in patients with prostate cancer on active surveillance (AS) and using the predicted risks to create risk-based personalised biopsy schedules as an alternative to one-size-fits-all schedules (e.g. annually). Furthermore, to assist patients and doctors in making shared decisions on biopsy schedules, by provid
Modern-day work is a central reason for unsustainability, and its transformation is therefore key for sustainability. A recurring manifestation of this issue is the ‘jobs-environment-dilemma’, a trade-off arising due to severe ecological impacts caused by work on the one hand, and the structural constitution of modern industrial society as work-centred and work-dependent on the other. We draw on iModern-day work is a central reason for unsustainability, and its transformation is therefore key for sustainability. A recurring manifestation of this issue is the ‘jobs-environment-dilemma’, a trade-off arising due to severe ecological impacts caused by work on the one hand, and the structural constitution of modern industrial society as work-centred and work-dependent on the other. We draw on i
This paper develops a more detailed understanding of when incumbent actors may become the main locomotive driving energy transitions. It also illustrates the trade-offs between policy approaches that actively seek to involve the incumbents in transitions, and policy approaches that pursue transitions without their active involvement. The paper examines state support for the bioeconomy in Sweden an
The European Spallation Source Neutrino Super Beam (ESSνSB) project aims at a discovery of leptonic CP violation with a precise measurement of the CP phase angle. ESSνSB is characterized by an intense neutrino beam to be produced at ESS by a 5-MW proton beam, and the placement of the far detector at the second oscillation maximum. The aims of the near detector for ESSνSB are neutrino flux and inte
Humanistic and positive psychology have had a contentious past. Initially, positive psychology researchers have distanced themselves from humanistic psychology, proceeding to build an array of differentiated constructs relevant to an empirical study of well-being. Twenty years on, it is now generally acknowledged that humanistic psychology is the theoretical predecessor of positive psychology in t
Antimicrobial peptides have emerged as a novel class of therapeutic molecules in recent decades as they exhibit broad-spectrum activity against a variety of Gram-positive, Gram-negative bacteria, fungi and tumor cells. Antimicrobial peptides are nature’s antibiotics that are conserved throughout the evolution. They have an advantage over conventional antibiotics as they target the cell membrane of
Background Postural orthostatic tachycardia syndrome (POTS) is characterized by excessive heart rate increase on standing and orthostatic intolerance. Previous data indicate autoimmune involvement. We studied serum activity against G protein-coupled receptors in relation to symptoms in patients with POTS and controls using a commercial cell-based assay. Methods and Results Forty-eight patients wit
The open-circuit voltage (Voc) of all-polymer solar cells (all-PSCs) is typically lower than 0.9 V even for the most efficient ones. Large energy loss is the main reason for limiting Voc and efficiency of all-PSCs. Herein, through materials design using electron deficient building blocks based on bithiophene imides, the lowest unoccupied molecular orbital (LUMO) energy levels of polymer acceptors
Objectives: To determine clinical characteristics and treatment complications of patients with late-stage Parkinsonism living in nursing homes compared with those living at home. Design: Cross-sectional analysis. Setting and Participants: This study is an analysis of 692 patients with late stage Parkinsonism recruited to an in-depth international study, Care of Late-Stage Parkinsonism (CLaSP). Mea
We investigated seven children from six families to expand the phenotypic spectrum associated with an early infantile epileptic encephalopathy caused by biallelic pathogenic variants in the phosphatidylinositol glycan anchor biosynthesis class Q (PIGQ) gene. The affected children were all identified by clinical or research exome sequencing. Clinical data, including EEGs and MRIs, was comprehensive
CuInSe2 (CISe) colloidal quantum dots (QDs) display promising applications in photodetection especially within near-infrared (NIR) regions due to their high extinction coefficient and environmental-friendly. However, the high trap density and poor crystal quality introduced by the ternary structure result in low photodetection of CISe QDs devices. Herein, we dope transition metal manganese ions (M
COVID-19 shocked health and economic systems leaving millions of people without employment and safety nets. The pandemic disproportionately affects people with substance use disorders (SUDs) due to the collision between SUDs and COVID-19. Comorbidities and risk environments for SUDs are likely risk factors for COVID-19. The pandemic, in turn, diminishes resources that people with SUD need for thei
Air sparging of alkaline-extracted wheat bran hemicelluloses prior to ultrafiltration has been shown to increase the flux. The techno-economic impact of air sparging on the cost of concentration and purification of wheat bran hemicelluloses by ultrafiltration and diafiltration was studied in this work. Two alkaline hemicellulose solutions were purified until the conductivity of the diafiltration p
Many ecosystem services (ES) models exist to support sustainable development decisions. However, most ES studies use only a single modelling framework and, because of a lack of validation data, rarely assess model accuracy for the study area. In line with other research themes which have high model uncertainty, such as climate change, ensembles of ES models may better serve decision-makers by prov
Rhodothermus marinus has the potential to be well suited for biorefineries, as an aerobic thermophile that produces thermostable enzymes and is able to utilize polysaccharides from different 2nd and 3rd generation biomass. The bacterium produces valuable chemicals such as carotenoids. However, the native carotenoids are not established for industrial production and R. marinus needs to be genetical
