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OBJECTIVE: The Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) is widely used for assessing disease activity in patients with axial spondyloarthritis (axSpA), particularly in settings where markers of inflammation are unavailable. As no consensus on BASDAI cut-off values exists for disease activity states in axSpA, we aimed to develop and validate such cut-offs against external criteri
AIMS: Metformin has hitherto not been proven superior to other type 2 diabetes (T2D) medications for the prevention of organ complications. The aim of this study is to report baseline data and blinded interim analyses in the register-based randomised clinical trial (RRCT) SMARTEST, which compares metformin and the SGLT2 inhibitor dapagliflozin in early T2D. We also present learnings from the novel
The production yields of antideuterons and antiprotons are measured in pp collisions at a center-of-mass energy of s=13 TeV, as a function of transverse momentum (pT) and rapidity (y), for the first time rapidity-differentially up to |y|=0.7. The measured spectra are used to study the pT and rapidity dependence of the coalescence parameter B2, which quantifies the coalescence probability of antide
Background and ObjectivesSpinocerebellar ataxias (SCAs) and other neurodegenerative cerebellar ataxias (N-SCAs) involve alterations in cerebellar structure and function, affecting motor control and sensorimotor integration but also cognitive functions such as visuospatial processing. The cerebellum is essential for sensorimotor functions, and it contributes to cognition. The study aims to assess s
The first measurement of HΛ3 and H‾Λ‾3 differential production with respect to transverse momentum and centrality in Pb–Pb collisions at sNN=5.02 TeV is presented. The HΛ3 has been reconstructed via its two-charged-body decay channel, i.e., HΛ3→3He+π−. A Blast-Wave model fit of the pT-differential spectra of all nuclear species measured by the ALICE collaboration suggests that the HΛ3 kinetic free
Cell cultures form the backbone for scientific research and development, but also for clinical diagnostics and biotechnology. Supplying cells in vitro with growth factors, hormones, and other nutrients is achieved most often by supplementing culture media with fetal bovine serum (FBS). Despite its nearly ubiquitous use, there are major reproducibility, safety, and animal welfare issues arguing the
It is predicted that continentality, a climate parameter representative of a region’s annual temperature and precipitation range, will undergo significant changes in the future. The lack of past continentality reconstructions makes it impossible to decipher any long-term patterns of continentality changes. Here, we investigate the extent to which continentality influences modern chironomid assembl
Background Obsessive-compulsive disorder (OCD) is associated with an increased risk of cardiometabolic disorders. We developed a lifestyle intervention, named LIFT, aimed at improving lifestyle habits (physical activity, diet, alcohol and tobacco use, stress, sleep) and reducing cardiometabolic risk factors in OCD. Aims This study aimed to establish the feasibility and acceptability of LIFT, evalu
North Sea-Progressive Myoclonus Epilepsy (NS-PME) is a progressive neurological disorder, initially only associated with the homozygous GOSR2 founder mutation (c.430G>T; p.Gly144Trp). Clinical symptoms include untreatable early-onset ataxia, cortical myoclonus and epilepsy. Recently, the spectrum of GOSR2 mutations and associated phenotypic variability has expanded. To improve care and to facilita
STUDY QUESTION Which spermatogonial differentiation states are present in prepubertal testes under normal conditions and following chemotherapy-induced depletion of spermatogonia in paediatric patients with cancer? SUMMARY ANSWER Single-cell transcriptomic analysis reveals that only undifferentiated spermatogonia are present in prepubertal boys, while differentiated states emerge during puberty, w
Background: Previous reports from relatively small clinical cohorts have suggested that the clinical presentation of obstructive sleep apnea (OSA) differs between men and women. Objective: We aimed to explore sex differences in clinical and polysomnographic features of OSA in a large nationwide registry. Methods: Participants from the ongoing Turkish Sleep Apnea Database (TURKAPNE) Study from 34 c
We analyze and compare the structure of two tables, the tables of al-Khwārizmī and George Peurbach’s Tabulae Eclypsium, looking at the syzygy angular velocities of the Sun and the Moon and the angular radii of the Sun, the Moon and the lunar eclipse umbra. We show that part of the underlying structure has a mediaeval Indian origin. Finally, we compare recomputed tables with Peurbach’s tables.
The growing use of 5G networks for critical services makes them vulnerable to Distributed Denial of Service (DDoS) attacks. While numerous Machine Learning (ML)-based approaches have been proposed, the real-world deployability of these models remains understudied. This work presents what is, based on existing literature, the first simulation-driven methodology to evaluate both the transferability
INTRODUCTION: Survival and healthcare for patients with congenital heart disease have improved, and the number of pregnancies among women of childbearing age with congenital heart disease has increased. Our aim was to investigate obstetric outcomes in a large retrospective, national registry study of women with congenital heart disease compared to controls.MATERIAL AND METHODS: The study included
Mechanisms of the aerosol indirect effects (AIEs) from ice nucleating particles (INPs) are investigated with the cloud-resolving “aerosol–cloud” (AC) model with a hybrid bin–bulk microphysics scheme coupled with a radiation scheme in 1) continental deep convection observed during the Midlatitude Continental Convective Clouds Experiment (MC3E) over Oklahoma and 2) supercooled stratiform clouds obse
In both second language acquisition research and teaching, there is a need for practical, reliable and valid proficiency tests to be used with learners of various target languages and at different proficiency levels. In the present study, a written proficiency test based on the C-test methodology was developed and tested on 144 Swedish 15-year-olds studying French, German, and Spanish in lower sec
