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Nya molekyler blockerar vattenkanaler som främjar tumörutveckling I detta projekt upptäcktes två nya molekyler som stänger aquaporin-3, en viktig vattenkanal i våra celler. Projektet kan öppna nya vägar för cancerbehandling genom att inaktivera ett centralt stödsystem för tumörtillväxt. Aquaporiner är små, specialiserade proteiner som bildar kanaler i cellmembranen. De kontrollerar vattenflödet This thesis identified two novel inhibitors of aquaporin-3 with comparable potency to the current leading compound, DFP00173. This achievement was based on the hypothesis that new aquaporin inhibitors could be developed by building upon the chemical structure of DFP00173. Aquaporins are a class of transport proteins responsible for the transport of water through the cell membranes. Aquaporin-3 is

År 2022 stod bygg- och fastighetssektorn för cirka 34 % av Sveriges totala energianvändning, där uppvärmning utgjorde den största andelen. Mot bakgrund av nationella och internationella klimatmål finns ett behov av att minska energianvändningen inom denna sektor. Detta examensarbete syftar till att undersöka hur boendebeteenden påverkar energianvändningen i ett flerbostadshus från 1960-talet, med This thesis investigates how occupant behavior affects energy use in multi-family buildings, with a particular focus on window airing. The study is centered on a 1960s residential building in Malmö, Sweden, equipped with a mechanical exhaust ventilation system. Using a combination of survey responses and measured data from a re-search project, occupant airing habits were analyzed and translated in

This study examines effective strategies for Swedish multinational companies to manage corruption risks in high-risk markets. Using Scania as a case study, it explores the gap between formal anti-corruption policies and actual practices, and the role of post-scandal reforms and NGOs, particularly Transparency International, in shaping corporate responses. While Swedish companies perform well domes

Under åren 1951–2002 släpptes en mängd på 2600–5000 ton PFAS ut i miljön. Det låter kanske inte så farligt. Men vad händer med miljön när denna mängd ökar? PFAS har konstaterats ha negativa effekter på daggmaskar, jordlevande bakterier och markhälsan. Dessa organismer är avgörande för att våra ekosystem ska fungera och för att vi ska kunna odla och bruka marken. Ändå är kunskapsläget kring PFAS påDuring the years 1951–2002, an amount of 2600–5000 tons of PFAS was released into the environment. The widespread occurrence of PFAS substances can have negative consequences for microbial species and communities within ecosystems, which is ex-pected to have negative effects also for higher trophic levels. Therefore, the purpose of this literature study was to compile information on which identifi

Brine disposal remains one of the most significant environmental challenges associated with desalination, driving the need for sustainable technologies such zero liquid discharge (ZLD) systems. Among emerging ZLD techniques, membrane distillation crystallization (MDCr) offers a promising approach by integrating water recovery with salt crystallization. In MDCr, a hydrophobic membrane separates wat

Denna studie undersöker nedsiderisken i nordiska hedgefonder under covid-19-krisen 2020 och inflationschocken 2022, i jämförelse med indexfonder, blandfonder och aktivt förvaltade aktiefonder. Value at Risk (VaR) och Expected Shortfall (ES) estimeras med en icke-parametrisk metod baserad på historisk simulering med ett rullande fönster på 36 månader. Skillnader mellan fondtyper testas för statistiThis paper investigates downside risk in Nordic hedge funds during the COVID-19 crisis of 2020 and the post-pandemic inflation crisis of 2022, comparing them to index funds, balanced funds, and actively managed equity funds. Value at Risk (VaR) and Expected Shortfall (ES) are estimated using a non-parametric method based on historical simulation with a rolling 36-month window. Differences across f

This thesis evaluates three interest rate models the HW1F, HW2F, and CIR++ from a risk management perspective. Through simulation, we examine their ability to generate realistic yield curves, as well as their impact on exposure metrics and CVA in different market environments. The CIR++ model consistently produces the highest and most conservative PFE estimates while also maintaining calibration

This thesis investigates how the integration of post-combustion carbon capture (PCC) systems would affect combined heat and power (CHP) plant performance, using DWSIM, an open- source process simulation tool. A case study on a CHP plant in southern Sweden was conducted, with models simulated for both baseline and CCS-integrated operation. DWSIM proved accurate within a relative error of under 3 %

Seminar date: June 4, 2025 Course: BUSN79 Authors: Ebba Rysjö Lindholm and Tilda Loudd Advisor/Examiner: Niklas Sandell/Liesel Klemcke Five key words: Account Theory, Legitimacy Theory, Crisis Communication, Allra, Financial Scandal Purpose: To examine how Allra, the Pensions Agency, Politicians, and Auditors used external communication to legitimize their actions throughout the Allra scanda

Human Activity Recognition (HAR) from wearable sensors is often constrained by limited labeled data and varying device placements. This thesis investigates a Transformer-based self-supervised approach that learns representations via a masked reconstruction and noise-injection pretext task, followed by fine-tuning on smaller labeled datasets. Experiments on WISDM, REALWORLD, and OPPORTUNITY confir

The All Pairs Shortest Path (APSP) problem is ubiquitous in computer science. The problem consists of finding for any vertex pair, the weighted shortest paths in a network with real-weighted edges. The problem has been studied thoroughly, both for dense graphs, where the number of edges can be quadratic in the number of vertices, and for sparse graphs, where the number of edges is considerably low

This Master’s thesis studies the effect of infrasound acoustic waves on heat transfer enhancement for industrial purposes. Previous research has demonstrated the cap ability of infrasound to cool steel uniformly, with performance comparable to forced convection. This opens the possibility of increasing the efficiency of the cooling process while also enabling new potential cooling methods for diff

Detta examensarbete har fokuserat på att modernisera styrsystemet för reservpanna 3 vid Hetvattencentralen i Landskrona, genom att ersätta ett äldre SCADA-baserat system Uniview med ett modernt distribuerat styrsystem (DCS) ABB 800xA. Arbetet har genomförts i samarbete med Deterministic Control AB, och med Landskrona Energi AB som slutkund. Syftet med examensarbetet har varit att uppnå en fullstänThis thesis focuses on the modernization of the control system for Backup Boiler 3 at District heating plant in Landskrona. The objective was to replace an outdated SCADA-based system, Uniview, with the modern Distributed Control System (DCS) ABB 800xA. The project was carried out in collaboration with Deterministic Control AB, and with Landskrona Energi AB as the final customer. The main goal was

This bachelor thesis explores nonbinary people’s experiences of joy and community, as well as how we are affected by social exclusion, anti-gender ideology, unintelligibility, and questions about whether nonbinary people actually exist. The aim of the thesis is to contribute to crucial efforts to amplify the voices and experiences of nonbinary people. Through interviews with five nonbinary people

As lithium-ion batteries become central to the European Union’s (EU) clean energy transition, particularly in electric vehicles and energy storage systems, concerns have grown regarding the sustainability of their full lifecycle. Recycling is increasingly recognized as a key strategy to mitigate environmental impacts, reduce reliance on primary raw materials, and support the EU’s circular economy

The purpose of this study is to examine how the Swedish court of law determined intent in cases of sexual and traffic offences where the defendant claimed to have acted whilst being in a state of somnambulism. The starting point of intent assessment is permeated with uncertainty about the defendant’s level of consciousness. Since there is a significant lack of guiding practice in cases of this nat

Utformningen av utrymmen för pianoframträdanden kan bidra till att forma pianistens psykologiska upplevelse, vilket i sin tur påverkar deras prestationsresultat. Denna avhandling utforskar hur rumsliga konfigurationer – såsom publikens närhet, scenens utformning, rummets storlek och belysning – kan påverka pianistens mentala tillstånd, inklusive stress, fokus och självförtroende vid scenframträdanThe arrangement of piano performance spaces can contribute to shaping the psychological experience of pianists, which in turn influences their performance outcomes. This thesis explores how spatial configurations—such as audience proximity, stage layout, performance room size, and lighting— could affect pianists' mental states, including stress, focus, and confidence when performing on stage.