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We have previously reported different spike firing correlation patterns among pairs of adjacent pyramidal neurons within the same layer of S1 cortex in vivo, which was argued to suggest that acquired synaptic weight modifications would tend to differentiate adjacent cortical neurons despite them having access to near-identical afferent inputs. Here we made simultaneous single-electrode loose patch
In assessing the current state of feminism and gender studies, whether on a theoretical or a practical level, it has become increasingly challenging to avoid the conclusion that these fields are in a state of disarray. Indeed, feminist and gender studies discussions are beset with persistent splits and disagreements. This reader suggests that returning to, and placing centre-stage, the role of phi
Empirical software engineering research relies on good communication with industrial partners. Conducting joint research both requires and contributes to bridging the communication gap between industry and academia (IA) in software engineering. This study aims to explore communication between the two parties in such a setting. To better understand what facilitates good IA communication and what pr
Protein methylation occurs primarily on lysine and arginine, but also on some other residues, such as histidine. METTL18 is the last uncharacterized member of a group of human methyltransferases (MTases) that mainly exert lysine methylation, and here we set out to elucidate its function. We found METTL18 to be a nuclear protein that contains a functional nuclear localization signal and accumulates
Disputes about how to understand intersectional relations often pivot around the tension between separateness and inseparability, where some scholars emphasise the need to separate between different intersectional categories while others claim they are inseparable. In this chapter the author takes issue with the either/or thinking that underpins an unnecessary and unproductive polarisation in the
In evaluating the current state of feminism and gender studies it has become increasingly challenging to avoid the conclusion that these fields are in a state of disarray; or, less calamitously, that they are in a state of considerable flux. While the presence of a diverse range of theoretical/political positions may simply reflect the vitality of the feminist movement - it does raise any number o
The recent World Malaria report shows that progress in malaria elimination has stalled. Current data acquisition by NMCPs depend on passive case detection and clinical reports focused mainly on Plasmodium falciparum (Pf). In recent times, several countries in sub-Saharan Africa have reported cases of Plasmodium vivax (Pv) with a considerable number being Duffy negative. The burden of Pv and Plasmo
Against influential strands of feminist theory, I argue that there is nothing essentialist or homogenising about the category ‘women’. I show that both intersectional claims that it is impossible to separate out the ‘woman part’ of women, and deconstructionist contentions that the category ‘women’ is a fiction, rest on untenable meta-theoretical assumptions. I posit that a more fruitful way of app
In the present study, according to the recirculation concept, a new elimination structure for the geyser in a cryogenic pipe is proposed. An eccentric spacer plate is used to stimulate the recirculation inside the cryogenic pipe. The geyser-elimination effect of the proposed structure is then validated and the elimination physics is explored. It is found that the geyser is successfully eliminated
Several devastating human diseases are linked to peptide self-assembly, but our understanding their onset and progression is not settled. This is a sign of the complexity of the aggregation process, which is prevented, catalyzed, or retarded by numerous factors in body fluids and cells, varying in time and space. Biophysical studies of pure peptide solutions contribute insights into the underlying
In this contribution we present some preliminary results on the dynamical evolution of two planet systems around stellar hosts evolving from the main sequence to the white dwarf phase. The aim is to study the instabilities triggered by stellar evolution that may bring planets onto the stellar surface or produce planetary scale collisions (hence debris) that could explain the metallic atmospheric p
SARS-CoV-2 is the causative agent of COVID-19. The dimeric form of the viral Mpro is responsible for the cleavage of the viral polyprotein in 11 sites, including its own N and C-terminus. The lack of structural information for intermediary forms of Mpro is a setback for the understanding its self-maturation process. Herein, we used X-ray crystallography combined with biochemical data to characteri
This ground-breaking volume on the relationships between tourism and innovation provides an overview of relevant innovation theories and related literatures on entrepreneurship, productivity, regional development and competitiveness, and their significance to contemporary tourism practices. Innovation is a key concept in business and entrepreneurial studies and the broader social sciences. Yet, de
One organizational innovation introduced by the clean energy for all Europeans package (CEP) is that of the energy community (EC), including the renewable energy community (REC) and citizen energy community (CEC). The translation of related directives into national legislation is underway in Sweden, and the Swedish Energy Market Inspectorate (Ei) has proposed a new law on ECs, which has been sent One organizational innovation introduced by the clean energy for all Europeans package (CEP) is that of the energy community (EC), including the renewable energy community (REC) and citizen energy community (CEC). The translation of related directives into national legislation is underway in Sweden, and the Swedish Energy Market Inspectorate (Ei) has proposed a new law on ECs, which has been sent
Purpose: Presence of disseminated tumour cells (DTCs) in the bone marrow (BM) has been described as a surrogate of residual disease in patients with early breast cancer (EBC). PADDY (Pooled Analysis of DTC Detection in Early Breast Cancer) is a large international analysis of pooled data that aimed to assess the prognostic impact of DTCs in patients with EBC. Experimental design: Individual patien
Studying the routes flown by long-distance migratory insects comes with the obvious challenge that the animal’s body size and weight is comparably low. This makes it difficult to attach relatively heavy transmitters to these insects in order to monitor their migratory routes (as has been done for instance in several species of migratory birds. However, the rather delicate anatomy of insects can be
