Sökresultat

Filtyp

Din sökning på "*" gav 533057 sökträffar

Cross Sectional Analysis of Stock Returns with Time-varying Beta

This paper analyses the ability of beta and other factors, like firm size and book-to-market, to explain cross‐sectional variation in average stock returns on the Swedish stock market for the period 1983–96. We use a bivariate GARCH(1,1) process to estimate time-varying betas for asset returns. The estimated variances of these betas, derived from a Taylor series approximation, are used for correct

Adenosine A(1) receptor agonists inhibit trigeminovascular nociceptive transmission

There is a considerable literature to suggest that adenosine A(1) receptor agonists may have anti-nociceptive effects, and we sought to explore the role of adenosine A(1) receptors in a model of trigeminovascular nociceptive transmission. Cats were anaesthetized (alpha-chloralose 60 mg/kg, intraperitoneally), and prepared for physiological monitoring. The superior sagittal sinus (SSS) was stimulat

Strain effects in perovskite manganites

Colossal magnetoresistance (CMR) - the dramatic reduction of electrical resistivity in a magnetic field and charge ordering (CO) in rare earth manganites of the type Ln(1-x)A(x)MnO(3) [Ln: rare earth, A: divalent cation] are manifestations of the intricate relation between orbital, spin, charge and lattice degrees of freedom. Recent studies indicate that the inhomogeneous state of mixed-valence ma

A stochastic model for subcellular dosimetry in boron neutron capture therapy

The therapeutic effectiveness of boron neutron capture therapy is highly dependent on the microscopic distribution of the administered boron compound. Two boron compounds with different uptake mechanisms in the tumour cells may thus cause effects of different degrees even if the macroscopic boron concentrations in the tumour tissue are the same. This difference is normally expressed quantitatively

Negative effect of DNA hypermethylation on the outcome of intensive chemotherapy in older patients with high-risk myelodysplastic syndromes and acute myeloid leukemia following Myelodysplastic syndrome

Purpose: Promoter hypermethylation of, for example, tumor-sup pressor genes, is considered to be an important step in cancerogenesis and a negative risk factor for survival in patients with myelodysplastic syndromes (MDS); however, its role for response to therapy has not been determined. This study was designed to assess the effect of methylation status on the outcome of conventional induction ch

Comparison of low dose nicotinamide versus benzamide, administered per os, as radiosensitizers in a C3H mammary carcinoma

We have evaluated if any differences in tumor radiosensitization exist between the two adenosine diphosphate ribosyl transferase (ADPRT) inhibitors nicotinamide and benzamide at fractionated low doses. A significant radiosensitizing effect with nicotinamide at a 10 mg/kg per day dose was found in the tumor model used. We found, however, no radiosensitizing effect with benzamide given according to

Efficacy of desmopressin in the treatment of nocturia: a double-blind placebo-controlled study in men.

OBJECTIVE: To investigate the efficacy and safety of oral desmopressin in the treatment of nocturia in men. PATIENTS AND METHODS: Men aged >/=18 years with verified nocturia (>or=two voids/night) and nocturnal urine production greater than their maximum functional bladder capacity were recruited. A 3-week dose-titration phase established the optimum desmopressin dose (0.1, 0.2 or 0.4 mg). After a

Restoration of tidal freshwater vegetation using controlled reduced tide (CRT) along the Schelde Estuary (Belgium)

Throughout the world, tidal marshes are being restored to obtain natural protection against recurring storm surges and sea level rise and to preserve the resources these habitats provide. Managed realignment, or breaching of the seaward dikes, is a restoration technique increasingly used; yet unsuitable site elevation has been a major constraint to habitat development. Controlled reduced tide (CRT

Nanostructured proton conducting polystyrene - poly(vinylphosphonic acid) block copolymers prepared via sequential anionic polymerizations

Poly(styrene-b-vinylphosphonic acid) diblock copolymers have been prepared via sequential anionic polymerization and evaluated as nanostructured polymer electrolytes. The ionic block copolymers were synthesized by first initiating the polymerization of styrene using n-butyllithium in tetrahydrofuran at −78 °C. 1,1-Diphenylethylene was then added to the living polystyryl anions before charging diet

A biogeochemistry-based dynamic vegetation model and its application along a moisture gradient in the continental United States

We develop and evaluate a large-scale dynamic vegetation model, TEM-LPJ, which considers interactions among water, light and nitrogen in simulating ecosystem function and structure. We parameterized the model for three plant functional types (PFTs): a temperate deciduous forest, a temperate coniferous forest, and a temperate C-3 grassland. Model parameters were determined using data from forest st

The meaning of women's experiences of living with multiple sclerosis

We conducted a qualitative inquiry in order to describe the meaning of women's experiences of living with multiple sclerosis (MS). Multiple sclerosis is a chronic autoimmune disease of the central nervous system. The majority of persons living with MS are women. Living with MS has been described as difficult because of the uncertainty of the illness. Ten women with MS were interviewed and the inte

Personality disorder features as predictors of symptoms five years post-treatment.

Personality disorders are associated with dysfunction in a variety of areas. Recent longitudinal research has shown that personality disorders are also predictive of problems later in life, as well as of poor response to treatment of depression and anxiety. This study assessed whether personality disorder features were associated with psychiatric symptoms in a cohort of women treated for substance

Worrisome thoughts in children clinically referred for anxiety disorders

Administered a 31-item worry measure, based on criteria from the Diagnostic and Statistical Manual of Mental Disorders (3rd ed., rev.; American Psychiatric Association, 1987) for anxiety disorders, to referred children with anxiety disorders (n = 72) or attention deficit hyperactivity disorder (ADHD; n = 50), and to nonreferred, never psychiatrically ill controls (n = 55). Anxiety and ADHD groups

P-Selectin and P-Selectin Glycoprotein Ligand 1 Mediate Rolling of Activated CD8+ T Cells in Inflamed Colonic Venules.

BACKGROUND:: Activated T cells regulate inflammatory diseases in the intestinal tract; however, the adhesive mechanisms governing CD8 T-cell recruitment in the colon are not known. METHODS:: Herein, we used a graft-versus-host disease (GvHD) model to study CD8 T-cell rolling and adhesion in the large intestine by use of intravital fluorescence microscopy. Graft-versus-host disease was induced by t

Electron paramagnetic resonance study of the S=1/2 ground state of a radiolysis-generated manganese(III)-trimanganese(IV) form of [Mn-IV;O-4(6)(bipy)(6)](4+) (bipy=2,2'-bipyridine). Comparison with the photosynthetic Oxygen Evolving Complex

gamma-Ray irradiation at liquid nitrogen temperature of a dimethylformamide solution of the tetranuclear complex [(Mn4O6)-O-IV(bipy)(6)](4+) (bipy = 2,2'-bipyridine) allowed the generation of the first mixed-valence tetranuclear system containing Mn-III and Mn-IV ions and exhibiting a S = 1/2 ground state. The X-band EPR spectrum of this tetranuclear system has been obtained. Simulations have been