Rescuing stalled ribosomes often involves their splitting into subunits. In many bacteria, the resultant large subunits bearing peptidyl-tRNAs are processed by the ribosome-associated quality control (RQC) apparatus that extends the C termini of the incomplete nascent polypeptides with polyalanine tails to facilitate their degradation. Although the tailing mechanism is well established, it is uncl

A collection of microswimmers immersed in an incompressible fluid is characterised by strong interactions due to the long-range nature of the hydrodynamic fields generated by individual organisms. As a result, suspensions of rear-actuated 'pusher' swimmers such as bacteria exhibit a collective motion state often referred to as 'bacterial turbulence', characterised by large-scale chaotic flows. The

BACKGROUND: Neutrophils and their inflammatory mediators are key pathogenic components in multiple autoimmune diseases, while their role in human type 1 diabetes (T1D), a disease that progresses sequentially through identifiable stages prior to the clinical onset, is not well understood. We previously reported that the number of circulating neutrophils is reduced in patients with T1D and in presym

In microbiological studies, a common goal is to link environmental factors to microbial activities. Both environmental factors and microbial activities are typically derived from bulk samples. It is becoming increasingly clear that such bulk environmental parameters poorly represent the microscale environments microorganisms experience. Using infrared (IR) microspectroscopy, the spatial distributi

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High-pressure torsion (HPT) is widely used as a key method for microstructure control through deformation processing across a broad range of materials. However, certain gaps in process control impact its efficacy. In this study, we investigate the acoustic emission (AE) signals generated during HPT by considering commercially pure molybdenum as an example. By employing the adaptive sequential k-me

The recent commercialisation of the first disease-modifying drugs for Alzheimer's disease emphasises the need for consensus recommendations on the rational use of biomarkers to diagnose people with suspected neurocognitive disorders in memory clinics. Most available recommendations and guidelines are either disease-centred or biomarker-centred. A European multidisciplinary taskforce consisting of

This article is based on two telematic theatre productions to better understand thepossibilities of the digital medium as well as the artistic challenges it brings. When producing the performances, the technology was very much in focus: how to act in front of the camera, how to relate to each other remotely and how the audience would watch the finished result became artistic problems that needed t

We determined the risk of late morbidity and mortality after autologous blood or marrow transplantation (BMT) for lymphoma performed before age 40. The cohort included autologous BMT recipients who had survived ≥2 years after transplantation (N = 583 [HL = 59.9%; NHL = 40.1%]) and a comparison cohort (N = 1070). Participants self-reported sociodemographics and chronic health conditions. A severity

CONTEXT: Agriculture plays a central role as a feedstock provider for the bioeconomy. However, utilization competing with food production and associated land use change have previously been a matter of debate. Nonetheless, strengthening the productivity of agroecosystems through sustainable intensification can prevent the depletion of natural resources, enhance food security, and facilitate adapta

The exceptional polymorphism observed within genes of the major histocompatibility complex (MHC), a core component of the vertebrate immune system, has long fascinated biologists. The highly polymorphic classical MHC class-I (MHC-I) genes are maintained by pathogen-mediated balancing selection (PMBS), as shown by many sites subject to positive selection, while the more monomorphic non-classical MH