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Scientific methods for integrating expert knowledge in Bayesian models

Generating scientific advice to environmental management involves assessments with complex models, sparse data, and challenging empirical experiments, necessitating the integration of expert judgment with data into scientific models. To integrate expert judgement, assessors might elicit judgement by experts as quantiles, find a probability distribution that matches the quantiles, and add this info

Interdisciplinary Approaches in Human-Agent Interaction

As the field of human-agent interaction (HAI) matures, it becomes essential to acknowledge and address the differing multidisciplinary approaches that support it to favor a common interdisciplinary understanding, thus adopting a broader methodological and epistemological perspective. The field of HAI recognizes that agents are not merely isolated technologies but embedded within society. Consequen

Tau protein spreads through functionally connected neurons in Alzheimer's disease : a combined MEG/PET study

Recent studies on Alzheimer's disease (AD) suggest that tau proteins spread through the brain following neuronal connections. Several mechanisms could be involved in this process: spreading between brain regions that interact strongly (functional connectivity); through the pattern of anatomical connections (structural connectivity); or simple diffusion. Using magnetoencephalography (MEG), we inves

Targeting neurotrophin and nitric oxide signaling to promote recovery and ameliorate neurogenic bladder dysfunction following spinal cord injury – Mechanistic concepts and clinical implications

This review summarizes the presentations made to a workshop entitled “Targeting Neurotrophin and Nitric Oxide Signaling to Promote Recovery and Ameliorate Neurogenic Bladder Dysfunction following Spinal Cord Injury – Mechanistic Concepts and Clinical Implications” at the International Continence Society (ICS) 2022 Vienna Meeting. Spinal cord injury (SCI; T8-T9 contusion/transection) causes impaire

Functional and molecular profiling of hematopoietic stem cells during regeneration

Hematopoietic stem cells (HSCs) enable hematopoietic stem cell transplantation (HCT) through their ability to replenish the entire blood system. Proliferation of HSCs is linked to decreased reconstitution potential, and a precise regulation of actively dividing HSCs is thus essential to ensure long-term functionality. This regulation becomes important in the transplantation setting where HSCs unde

The Dynamics of Nerve Degeneration and Regeneration in a Healthy Milieu and in Diabetes

Appropriate animal models, mimicking conditions of both health and disease, are needed to understand not only the biology and the physiology of neurons and other cells under normal conditions but also under stress conditions, like nerve injuries and neuropathy. In such conditions, understanding how genes and different factors are activated through the well-orchestrated programs in neurons and othe

Artificial synaptic characteristics of PVA:ZnO nanocomposite memristive devices

Computational efficiency is significantly enhanced using artificial neural network-based computing. A two-terminal memristive device is a powerful electronic device that can mimic the behavior of a biological synapse in addition to storing information and performing logic operations. This work focuses on the fabrication of a memristive device that utilizes a resistive switching layer composed of p

Acupuncture for procedural pain in newborn infants

Objectives: This is a protocol for a Cochrane Review (intervention). The objectives are as follows:. To assess the benefits and harms of acupuncture in newborn infants undergoing painful procedures.

Endoscopic and Surgical Management of Non-Metastatic Ampullary Neuroendocrine Neoplasia : A Multi-Institutional Pancreas2000/EPC Study

Introduction: Ampullary neuroendocrine neoplasia (NEN) is rare and evidence regarding their management is scarce. This study aimed to describe clinicopathological features, management, and prognosis of ampullary NEN according to their endoscopic or surgical management. Methods: From a multi-institutional international database, patients treated with either endoscopic papillectomy (EP), transduoden

Clinical use of an emergency manual by resuscitation teams and impact on performance in the emergency department : A prospective mixed-methods study protocol

Introduction Simulation-based studies indicate that crisis checklist use improves management of patients with critical conditions in the emergency department (ED). An interview-based study suggests that use of an emergency manual (EM) - a collection of crisis checklists - improves management of clinical perioperative crises. There is a need for in-depth prospective studies of EM use during clinica

Positioning for lumbar puncture in newborn infants

BACKGROUND: Lumbar puncture is a common invasive procedure performed in newborns for diagnostic and therapeutic purposes. Approximately one in two lumbar punctures fail, resulting in both short- and long-term negative consequences for the clinical management of patients. The most common positions used to perform lumbar puncture are the lateral decubitus and sitting position, and each can impact th

En misogyn kaskad

En essä över skildringen av Roms kvinnor utifrån Eva Queckfeldts bok Romarrikets kvinnor

The History of African Development : A textbook for a new generation of African students and teachers

The History of African Development – published by the African Economic History Network (AEHN) – aims to draw experts in the field of African History, Economics and African Development Studies together around an open access textbook. The textbook is primarily intended for teachers/lecturers and undergraduate students, at African universities, but also for an interested wider public audience. The AE

Income inequality and export-orinted commecialization in colonial Africa: Evidence from six countries

Limited knowledge of African historical inequality trajectories hampers our understanding of inequality outcomes today and leads to a major omission in debates about global inequality. Economies in colonial Africa were characterized by a process of export-oriented commercialization. We hypothesize that this process itself, the capital intensity of the commodities produced, and the relative importa

Hybrid elicitation and quantile-parametrized likelihood

This paper extends the application of quantile-based Bayesian inference to probability distributions defined in terms of quantiles of observable quantities. Quantile-parameterized distributions are characterized by high shape flexibility and parameter interpretability, making them useful for eliciting information about observables. To encode uncertainty in the quantiles elicited from experts, we p