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Successful translation requires multiple protein factors with diverse specific activities. Initiation of translation is regarded as the most tightly regulated step of this process, controlled by numerous factors. Among these is the eukaryotic initiation factor 4F (eIF4F), a protein complex composed of three subunits: the cap-binding protein eIF4E, the RNA helicase eIF4A, and the scaffolding protei
DNA replication relies on precise coordination between proteins, including the sliding clamp proliferating cell nuclear antigen (PCNA), which encircles DNA to interact with key players in replication and repair. While biochemical studies have demonstrated interactions between PCNA and DNA polymerases δ and ε during DNA synthesis, the functional role of the Pol ε–PCNA interaction in vivo, particula
Fler än 800 000 svenskar har privata sjukvårdsförsäkringar, men effekten detta har på svensk sjukvård och jämlikhet går inte att följa i svenska register.
When the polar vortex meanders and shifts towards the equator, air masses from the tropics and subtropics can be transported towards the pole in so-called tropical-subtropical streamers. These large-scale structures are areas of low potential vorticity and high pressure, containing dry air with high ozone mixing ratios. The presence of these streamers can also be seen in changes in stratospheric o
Uronate isomerase (EC 5.3.1.12; URI) catalyzes uronate sugar interconversion, a key step in bacterial metabolism, yet its reaction mechanism remains poorly understood. This study delineates the detailed mechanism for the isomerization of d-glucuronate to d-fructuronate catalyzed by a Zn2+-dependent URI enzyme (from Bacillus halodurans). Using quantum mechanical (QM) cluster calculations, three mec
Antimicrobial peptides are widely investigated in the literature, but their mechanism of action and effects on lipid membranes are not completely understood from a physicochemical perspective. In this study, we employed a bioinspired mastoparan from wasp venom, mast-MO, and characterized its interactions with model lipid membranes, either as a supported lipid bilayer or as free-standing vesicles i
Understanding the behavior of electron spins in nanomaterials is crucial for the advancement of quantum technologies. However, studying single spins presents significant challenges both experimentally and theoretically, as radicals are often unstable under experimental conditions, and sophisticated quantum mechanical approaches with extremely high computational demands, such as CASPT2 and NEVPT2,
A forthcoming taxonomic treatment of the genus Verbascum in Greece in the frame of The Flora of Greece Project necessitates the description of one species and two subspecies as new to science, the upgrading to subspecies rank of two taxa formerly recognized as varieties, as well as the formation of two new combinations. Verbascum bolbes from the regional unit Thessaloniki is here described as a ne
Objective Delivery of a small for gestational age (SGA) infant is a common pregnancy complication among women with SLE. Although disease activity and autoantibodies such as anti-Smith and anti-ribonucleoprotein associate with SGA, underlying pathological mechanisms remain unclear and reliable predictors are lacking. To address this, we applied a proteomic approach to identify proteins associated w
Background: Three-quarters of all mental health problems begins between 10-24 years. When not treated, adolescents and young people with mental health problems are at high risk of abuse, suicide, and substance use, which have long-term consequences that negatively impact physical, and economic productivity. The study aimed to determine the prevalence of mental health problems among secondary schoo
The extent to which public health interventions and medical innovations have improved population health has long been debated. This thesis addresses this question by examining anti‑tuberculosis (TB) campaigns—often considered the first modern public health campaigns—through the case study of twentieth‑century Sweden.The thesis begins by documenting the rise and fall of Sweden’s anti‑TB campaigns,
Ur skriften: "Från juni 2022 till december 2025 visades utställningen ”Lunds universitet – historia och historier” på Historiska museet vid Lunds universitet. Utställningen producerades i samarbete med Lunds universitetshistoriska sällskap. Denna skrift återger merparten av innehållet i utställningen. Vissa texter har uppdaterats utifrån senare händelser och upptäckter."
According to Ethan Mollick, artificial intelligence (AI) is the most recent general purpose technology (GPT), the “once-in-a-generation technologies, like steam power or the internet, that touch every industry and every aspect of life” (2024, p. xv). Unlike the slowly unfolding transformations caused by these earlier GPTs, the changes sparked by AI seem to evolve daily. This rapid pace creates a s
Microhabitat choice has been proposed as a mechanism contributing to the maintenance of colour polymorphism in marine gastropods, based on observed associations between shell colour and microhabitat in certain species (e.g. Littorina saxatilis). To examine this hypothesis, different colour morphs of L. saxatilis were studied following a mark-recapture experimental design to assess whether this spe
Context. Stellar radial migration has predominantly been examined in isolated disc galaxies where non-axisymmetric structures drive the process. By contrast, while tidal interactions are known for having an influence, their contribution remains comparatively under explored. The Large Magellanic Cloud (LMC), the nearest disc galaxy to the Milky Way (MW) and currently interacting with the Small Mage
