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The mechanisms underlying antimicrobial and anti-endotoxic effects were investigated for a series of structurally related peptides derived from the C-terminal region of S1 peptidases. For this purpose, results on bacterial killing were compared to those on peptide-induced liposome leakage, and to ellipsometry and dual polarization interferometry results on peptide binding to, and disordering of, s
Popular Abstract in Swedish Hjärtat pumpar blod genom ett nätverk av blodkärl, vilket för ut syre och näringsämnen till organen och för tillbaka restprodukter som bryts ned eller utsöndras från kroppen. När hjärtat pumpar byggs det upp ett tryck som driver blodet genom kärlsystemet, från artärter till vener via ett förgrenat nät av kapillärer, som svarar för utbytet med vävnadsvätskorna. BlodflödeSmooth muscle cells residing in the blood vessel media are constantly exposed to mechanical forces exerted by the intraluminal pressure. The smooth muscle senses and adapts to mechanical forces by activation of multiple signaling pathways and cytoskeletal rearrangements. Stretch of the vascular wall is therefore an important factor that controls smooth muscle cell phenotype and function. The goal
Despite increased awareness of the urgency to respond to climate change and to promote sustainable development, there are few powerful initiatives that are decisively shifting urban development in a sustainable, resilient and low-carbon direction. This Special Volume of the Journal of Cleaner Production explores sustainable urban transformation focusing on structural transformation processes – mul
Adipose tissue does not only store and release energy in response to hormones, it is also known as an endocrine organ, secreting important factors and hormones that influence for example appetite and insulin sensitivity. The association of type 2 diabetes with obesity has been known for quite some time. Understanding the cellular mechanisms of adipocyte function is of great importance in understan
German lichen flora projects are surveyed from Georg Hoffmann’s Deutschlands Flora oder Botanisches Taschenbuch. Zweyter Theil für das Jahr 1795. Cryptogamie to the recently published Die Flechten Deutschlands 2013, via Wilhelm Körber’s Systema Lichenum Germaniae 1855, and the supplementary volume Parerga lichenologica 1859, Gustav Lindau’s Die Flechten, Kryptogamenflora für Anfänger 1913 & 19
This article scrutinizes the role of structural change and foreign trade in the Nordic countries, except Iceland, in industrialization prior to 1914. Sector contribution to GDP as well as the role of the foreign trade is compared across the countries. The comparison uncovers different paths to industrialization that cannot be explained by reference to received views, such as the shock of free trad
During ascending evacuation in long stairs, there is reason to believe that factors such as physical exhaustion, human behaviour and the mental state will influence the possibility of satisfactory evacuation and affect walking speed and flow rate of people. Based on these hypotheses, a research project was initiated. As a part of the project, an initial literature study has been conducted. The lit
Physiological changes due to aging are intensively studied as they have far-reaching implications for the mechanistic and evolutionary theories of senescence. In this respect, metabolic rate has been suggested to play a role for the deterioration and damage of cells and tissues with age, partly due to the generation of reactive oxygen species. To mitigate such damage, individuals can be predicted
The fatty acid specificity of five lipases towards eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) was evaluated in the hydrolysis of fish oil, squid oil and a model system. The model system contained methyl esters of EPA, DHA and palmitic acid. All the investigated lipases discriminated against both EPA and DHA more in the model system than in the natural oils. Thus both EPA and DHA we
After severe acquired brain injury some patients develop a prolonged disorder of consciousness (vegetative state or minimally conscious state), and as such cannot actively participate in neurorehabilitation. However, international opinion and recent research developments emphasize the need for involvement of rehabilitation medicine units in the care of these patients. The article presents recommen
Stable walking depends on the coordination of multiple biomechanical degrees of freedom to ensure the dynamic maintenance of whole-body equilibrium as well as continuous forward progression. We investigated adult age-related differences in whole-body coordination underlying stabilization of center of mass (CoM) position and step pattern during locomotion. Sixteen younger (20-30 years) and 16 healt
Pulsating flow through bifurcations are of general interest. In the human body such flows are also very common; for example in blood vessels and the respiratory tract. The characteristics of the flow in arteries have been related to the process of atherogenesis, based on the observation that the initial manifestation of the process is observed at certain common locations, i.e., near bifurcations i
Popular Abstract in Swedish Skador på skelettet kan uppstå efter bl.a. olyckor, tumörkirurgi eller strålning. Ofta är sådana skador mycket handikappande då de påverkar kroppens funktion, stabilitet och utseende. Om benvävnad saknas eller måste bytas ut använder man sig idag av mikrokirurgiska metoder, där man flyttar kroppseget ben från ett ställe till ett annat. Tyvärr innebär detta att man skapaBone deficiencies, caused by malformations, trauma or adverse effects from medical treatments, are a clinical challenge and often associated with reduced physical function and quality of life. Autologeous bone grafts can be used to reconstruct skeletal defects, but the right size and quality of bone might not always be available and even so, donor-site morbidity might follow. A pre-fabricated or t
We prove a strong comparison theorem in the class ${\cal E}_p(\Omega)$ of certain plurisubharmonic functions with infinite total complex Monge-Amp\`ere masses. We also obtain a convergence theorem in ${\cal E}_p(\Omega)$
L-2,L-3-edge X-ray absorption spectroscopy (XAS) has demonstrated unique capabilities for the analysis of the electronic structure of di-Ru complexes such as the blue dimer cis,cis-[(Ru2O)-O-III(H2O)(2)(bpy)(4)](4+) water oxidation catalyst. Spectra of the blue dimer and the monomeric [Ru(NH3)(6)](3+) model complex show considerably different splitting of the Ru L-2,L-3 absorption edge, which refl
