The search for significantly overrepresented and co-occurring transcription factor binding sites in the promoter regions of the most differentially expressed genes in microarray data sets could be a powerful approach for finding key regulators of complex biological processes. To test this concept, two previously published independent data sets on wounded human epidermis were re-analyzed. The prese

In many-body and other systems, the physics situation often allows one to interpret certain, distinct states by means of a simple picture. In this interpretation, the distinct states are not eigenstates of the full Hamiltonian. Hence, there is an interaction that makes the distinct states act as doorways into background states which are modeled statistically. The crucial quantities are the overlap

We present a very simple polymer model of polyethylene glycols/oxides in water that can be used in combination with Molecular Dynamics or Monte Carlo simulations to accurately reproduce the equation of state and radii of gyrations across several orders of magnitude, in terms of osmotic pressure and polymer length. This is of importance for example in osmotic stress experiments, with the aim to acc

BackgroundThere is a need to develop and validate surrogate markers of cardiovascular disease (CVD) in subjects with diabetes. The macrovascular changes associated with diabetes include aggravated atherosclerosis, increased arterial stiffness and endothelial dysfunction. The aim of this study was to determine which of these factors is most strongly associated with clinically manifest cardiovascula

The planet candidates discovered by the Kepler mission provide a rich sample to constrain the architectures and relative inclinations of planetary systems within approximately 0.5 AU of their host stars. We use the triple-transit systems from the Kepler 16 months data as templates for physical triple-planet systems and perform synthetic transit observations, varying the internal inclination variat

REVEALS-based quantitative reconstruction of Holocene vegetation cover (expressed in plant functional types. PFTs) is used in the LANDCLIM project to assess the effect of human-induced land-cover change on past climate in NW Europe. Using the Czech Quaternary Pollen Database, this case study evaluates the extent to which selection of data and input parameters for the REVEALS model applications wou

In this study, we have analyzed the spatial and temporal correlation between the North Atlantic Oscillation (NAO) and the climate in Iraq, with a focus on precipitation, temperature, and number of Mediterranean cyclones. It was found that the influence of the NAO varies per climate indicator. For example, the influence is greater on precipitation than on temperature. One conclusion of the study is

Genomic gain of the proto-oncogene transcription factor gene MYCN is associated with poor prognosis in several childhood cancers. Here we present a comprehensive copy number analysis of MYCN in Wilms tumour (WT), demonstrating that gain of this gene is associated with anaplasia and with poorer relapse-free and overall survival, independent of histology. Using whole exome and gene-specific sequenci

Comparing species differences in covariance patterns of traits subject to divergent selection pressures can increase our understanding to the mechanisms of phenotypic divergence. Different species of calopterygid damselflies have diverged in the melanized wing patch of males. This trait serves multiple ecological functions and has behavioral consequences in terms of sexual selection, interspecific

Results on fabrication and DC-characterisation of vertical InAs nanowire wrap-gate field-effect transistor arrays with a gate length of 50 nm are presented. Each nanowire array was processed into a transistor with a systematic variation in a number of wires and wire diameter over the sample. Extensive studies have been performed on the influence of wire number and diameter on the transistor charac

In this short note, we argue that performance per watt, which is often cited in the graphics hardware industry, is not a particularly useful unit for power efficiency in scientific and engineering discussions. We argue that joules per task and watts are more reasonable units. We show a concrete example where nanojoules per pixel is much more intuitive, easier to compute aggregate statistics from,

Background and purpose Roentgen stereometric analysis (RSA) cannot discern whether a single prosthesis is fixed or migrating below the detection level. Samples of patients usually show migration values that appear to be continuously distributed. Is there such continuity, or is there a dichotomy between stable and migrating prostheses? The hypothesis of a dichotomy has, to our knowledge, not been t

Previous research has shown that wheelchair-seated passengers using special transportation services (STS) have been injured without being involved in a vehicle crash. In order to estimate incident rate and societal costs for these vehicle-related injuries, the focus needs to be adjusted towards a traveler/incident-oriented perspective. The aim of the project was to utilize such a perspective, rela

Recension av Charles Whiting, Hitlers fallskärmsjägare – elitförband i strid 1940–45.

Within both psycholinguistic theories of parsing and formal theories of syntax, a distinction between arguments and adjuncts is central to some theories, while minimized or denied by others. Even for theories that deem the argument/ adjunct distinction important, the exact nature of the distinction has been difficult to characterize. In this article, we review the psycholinguistic evidence for an

Constraining the temperature of computing systems has become a dominant design aspect. The supply voltage decrease has lost its pace even though the feature size is shrinking constantly. This results in an increased number of transistors per unit of area and hence a growing power density. Researchers started investigating dynamic thermal management techniques to trade-off performance for energy co

CCAAT-enhancer binding protein β (C/EBPβ) is a transcription factor that has a critical role in mammary gland development and breast cancer progression. Loss of C/EBPβ increases metastatic dissemination of mouse mammary tumor cells. However, the mechanism by which C/EBPβ expression affects metastasis formation remains unknown. This study aims at determining the relationship between C/EBPβ and surv