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Accumulation of the tumour-suppressor protein p53 in breast cancer is associated with several prognostic factors that indicate an aggressive, rapidly proliferating tumour with an unstable genome. To assess p53 accumulation in stage I breast cancer and to evaluate the prognostic value of both nuclear and cytoplasmic p53, 205 patients with node-negative breast cancer and tumour size less than or equ
Functional p53 protein is essential for the cellular response to drug-induced DNA damage. We investigated p53 accumulation in tumour specimens from premenopausal breast cancer patients who were randomised to adjuvant chemotherapy (CMF) or postoperative radiotherapy. Of the tumours from 139 patients, 20 showed abnormal accumulation as judged with immunohistochemistry (> 10% positive tumour cells).
A novel quantitative luminometric immunoassay (LIA) has been developed for the measurement of wild-type and mutant p53 protein in extracts from breast tumour tissue. The LIA was found to yield reliable estimates of p53 expression in cytosol samples routinely prepared for steroid receptor analysis as compared with results obtained with immunohistochemical analysis. The LIA was evaluated on 205 prim
Knut Wicksell var en banbrytande nationalekonom. Hans penningteori styr fortfarande dagens politik. Och han deltog med liv och lust i den offentliga debatten. Lars Jonung minns en svensk provokatör som blev internationellt erkänd.
Juvenile polyposis syndrome (JPS) is a rare genetic disorder characterized by juvenile polyps of the gastrointestinal tract. We present a new pathogenic mutation of the SMAD4 gene and illustrate the need for a multidisciplinary health care approach to facilitate the correct diagnosis. The patient, a 47-year-old Caucasian woman, was diagnosed with anaemia at the age of 12. During the following 30 y
Children undergoing surgery for posterior fossa tumours (PFT) may experience postoperative language and communication difficulties, regardless of whether they develop cerebellar mutism syndrome (CMS) or not. While these language difficulties are increasingly recognised in current research, children’s own experiences of everyday communication remain limited. In this presentation, we share findings
PurposeTo explore the cultural embeddedness of (un)welcome experiences among ethnically marginalized consumers in retail spaces.Design/methodology/approachDrawing on Arjun Appadurai's notion of the ethnoscape, the study is empirically grounded in critical-incident interviews with consumers from multiethnic backgrounds in Sweden.FindingsThree dimensions through which (un)welcome is negotiated are i
To examine longitudinal trajectories of pain occurrence in children with cerebral palsy (CP) aged 1 year to 17 years.A longitudinal register-based study was conducted using data from the Swedish Cerebral Palsy Follow-up Program (2007-2023). Individuals (n = 4887) with confirmed CP, a minimum of three pain assessments, and any Gross Motor Function Classification System (GMFCS) levels were included
Incretin-based therapies, including glucagon-like peptide-1 receptor agonists (GLP-1RAs), are approved for the treatment of type 2 diabetes, obesity, and related conditions, and have demonstrated significant benefits for individuals with these conditions. However, in recent years, public interest and demand for GLP-1RAs-often driven by media, social media influencers, advertising, and public disco
BACKGROUND: Weight-related bias, stigma, and discrimination significantly affect quality of life and health in persons with obesity. Their influence on post-operative outcomes following metabolic surgery and bariatric remains underexplored.OBJECTIVES: This systematic review aimed to evaluate any impact of pre- and post-operative weight bias, stigma, and discrimination on post-metabolic and bariatr
The preterite-present verb (ge)munan, meaning ‘to remember’ or ‘to be mentally active’, is attested throughout the Old English period (450-1150). Deriving from the Proto-Germanic preterite-present lexical verb munan, it belongs to a class of verbs many of which grammaticalised into modal auxiliaries during Old and Middle English. (Ge)munan itself appears to have undergone grammaticalisation, as su
This international, multidisciplinary consensus report represents the first effort to systematically define and characterize fatty pancreas. A key outcome of this endeavor was the recommendation to adopt "fatty pancreas" as the standardized and inclusive term to describe all forms of fat accumulation in the pancreas. This terminological consensus provides a critical foundation for unified reportin
Food intake induces metabolic and hemodynamic changes, but its impact on many circulating protein biomarkers remains unclear. This study assessed the effect of a standardised meal on 85 plasma biomarkers measured by the Proseek Multiplex Metabolism panel. Twenty-two healthy adults (11 men, 11 women; mean age 25.9 ± 4.2 years) were examined after an overnight fast and at 30 and 120 min following
BACKGROUND: Glioblastoma (GBM) is the most prevalent and malignant primary brain tumor in adults. While immune evasion is a well-recognized driver of GBM progression and a major obstacle for efficient immunotherapy, the role of the complement system remains underexplored. C1-inhibitor (C1-INH), a regulator of complement activation, was recently found overexpressed in GBM. We therefore hypothesized
We consider two optimization problems in which a planner aims to influence the average transient opinion in the Friedkin-Johnsen dynamics on a network by intervening on the agents' innate opinions. Solving these problems requires full network knowledge, which is often not available because of the cost involved in collecting this information or due to privacy considerations. For this reason, we foc
Structured Abstract Background Sexual health and functioning are significant, yet often overlooked, components of psychosocial well-being of adults with congenital heart disease (ACHD). Prior research reports inconsistent findings, limited data on older adults with CHD, and few studies have compared patients with controls from the general population. This study investigated sexual functioning in m
