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The presence of amyloid fibrils is a hallmark of several neurodegenerative diseases. Some amyloidogenic proteins, such as α-synuclein and amyloid β, interact with lipids, and this interaction can strongly favour the formation of amyloid fibrils. In particular the primary nucleation step, i.e. the de novo formation of amyloid fibrils, has been shown to be accelerated by lipids. However, the exact m
The role of human leukocyte antigen (HLA) class I and killer immunoglobulin-like receptor molecules in mediating acute retroviral syndrome (ARS) during human immunodeficiency virus type 1 (HIV-1) infection is unclear. Among 72 sub-Saharan African adults, HLA-A*23 was associated with lower odds of ARS (adjusted odds ratio, 0.10 [95% confidence interval, .01–.48]; P = .009), which warrants further s
Modern subgraph-finding algorithm implementations consist of thousands of lines of highly optimized code, and this complexity raises questions about their trustworthiness. Recently, some state-of-the-art subgraph solvers have been enhanced to output machine-verifiable proofs that their results are correct. While this significantly improves reliability, it is not a fully satisfactory solution, sinc
Background In addition to the diagnostic accuracy of imaging methods, patient-reported satisfaction with imaging methods is important. Objective To report a secondary outcome of the prospective international multicenter Imaging Study in Advanced ovArian Cancer (ISAAC Study), detailing patients’ experience with abdomino-pelvic ultrasound, whole-body contrast-enhanced computed tomography (CT), and w
Although customer engagement has been deemed critical for optimizing social media marketing performance, prior research has mainly examined customer engagement through cross-sectional designs, thus limiting insight into its evolving dynamics over time. To address this gap, we adopt uses-and-gratifications theory to explore the associations among customers' evaluations of a firm's social media mark
Introduction: Alcohol use disorder (AUD) is among the strongest correlates of suicide death, but it is unclear whether AUD status is differentially associated with risk of suicide by particular methods. Methods: The authors used competing risks models to evaluate the association between AUD status and risk of suicide by poisoning, suffocation, drowning, firearm, instruments, jumping, or other mean
Determining the child’s best interests in a hospital setting will ideally involve the combined views of children, parents, and healthcare professionals. However, few studies have explored parents’ experiences of their child’s best interests when they engage with the healthcare system. Therefore, this study aimed to explore parents’ experiences of their child’s best interests during hospitalisation
Objectives: Fusobacterium necrophorum is a common cause of pharyngotonsillitis. However, no guidelines exist on when to diagnose or treat it. We aimed to investigate associations between clinical criteria and F. necrophorum-positivity in pharyngotonsillitis and assess the predictive potential of a simple scoring system. Methods: Pharyngotonsillitis patients who were tested for F. necrophorum (PCR)
The late nineteenth and early twentieth century saw a widespread interest in Asian religion within European and American esotericism. Whereas most of that interest was directed toward India, a number of representatives of the early twentieth-century esoteric environment turned toward East Asia in order to find what they hoped to be a spiritual solution to the problems of their time. One of these i
We utilize the reconstruction of attosecond beating by interference of two-photon transitions (RABBITT) technique to study the phase of a Rabi-cycling atom using circularly polarized extreme ultraviolet and infrared fields, where the infrared field induces Rabi oscillations between the 2s and 2p states of lithium. Autler-Townes splittings are observed in sidebands of the photoelectron spectra and
INTRODUCTION: We assessed whether macro- and/or micro-structural white matter properties are associated with cognitive resilience to Alzheimer's disease pathology years prior to clinical onset. METHODS: We examined whether global efficiency, an indicator of communication efficiency in brain networks, and diffusion measurements within the limbic network and default mode network moderate the associa
The bone marrow (BM) niche is a complex cellular, molecular, and physical microenvironment capable of homing and supporting hematopoiesis. It is characterized by its ability both maintain and to drive hematopoietic stem and progenitor cells (HSPCs) self-renewal and differentiation which ultimately generate all blood cell types. However, how the niche elements interact in a human context remains la
Water damage affects both residents and buildings. Issues include moisture, climate impact and repair costs that amount to immense resources. Because of these, immense resources research is important to undertake to reduce and limit the extent and effects of water damage. This study aimed to compile and review the literature on water damage in buildings. Literature distribution, the status, conseq
The pending ecological crisis has ushered in a need to rethink how electricity is produced and consumed, which in turn will require new ways of maintaining system balance. One solution that has gained traction over the past decade is the idea of user flexibility. User flexibility is by some deemed integral to the transition towards a low-carbon society and to the decarbonization agenda, and its inThe pending ecological crisis has ushered in a need to rethink how electricity is produced andconsumed, which in turn will require new ways of maintaining system balance. One solution that hasgained traction over the past decade is the idea of user flexibility. User flexibility is by some deemedintegral to the transition towards a low-carbon society and to the decarbonization agenda, and itsintegr
Tropical ecosystems have an important role in global change scenarios, in part because they serve as a large terrestrial carbon pool. Carbon protection is mediated by soil aggregation processes, whereby biotic and abiotic factors influence the formation and stability of aggregates. Nutrient additions may affect soil structure indirectly by simultaneous shifts in biotic factors, mainly roots, and f
The influence of ectomycorrhizal fungi on the soil bacterial community was studied by growing pine seedlings in artificial soils consisting of a peat/sand mixture amended with microcline, biotite or apatite. In the microcline-amended and unamended soils both Suillus variegatus and Paxillus involutus reduced bacterial activity as measured by thymidine incorporation. S. variegatus grew best in the b
We live in ‘Tomorrowland’; a land at the nexus of social science and natural science where the solution to our problems will be found tomorrow. The paper addresses the impossibility of international relations by proposing an alternative approach located in critical social theory. The paper utilises critical social theory to critique contemporary liberal assumptions and rationalisations of cultures
