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This review describes how computational methods have contributed to the held of cobalamin chemistry since the start of the new millennium. Cobalamins are cobalt-dependent cofactors that are used for alkyl transfer and radical initiation by several classes of enzymes. Since the entry of modern electronic-structure calculations, in particular density functional methods, the understanding of the mole
Chlorophyll biosynthesis is initiated by magnesium chelatase, an enzyme composed of three proteins, which catalyzes the insertion of Mg2+ into protoporphyrin IX to produce Mg-protoporphyrin IX. In barley (Hordeum vulgare L.) the three proteins are encoded by Xantha-f, Xantha-g and Xantha-h. Two of the gene products, XanH and XanG, belong to the structurally conserved family of AAA+ proteins (ATPas
Mainstream transitional justice and peacebuilding practices tend to re-entrench gendered hierarchies by ignoring women or circumscribing their presence to passive victims in need of protection. As a consequence we have limited knowledge about the multifaceted ways women do justice and build peace. To address this lacuna we conceptualize and unpack the meaning of gendered agency, by identifying its
With a worldwide increase in disasters, the effects of climate change are already being felt, and it is the urban poor in developing countries who are most at risk. There is an urgent need to better understand the factors that determine people's capacity to cope with and adapt to adverse climate conditions. This paper examines the influence of formal education in determining the adaptive capacity
Response of passerine birds to an irruption of a pine processionary moth Thaumetopoea pityocampa population with a shifted phenology The main purpose of the present work was to investigate if the passerine community was able to respond to it localized irruption of a temporally shifted population of the pine processionary moth Thaumetopoea pityocampa, the larval development of which takes place dur
We report on a search of relations valid at order p(6) in Chiral Perturbation Theory. We have found relations between pi, pi K scattering, K-l4 decays, masses and decay constants and scalar and vector formfactors. In this paper we give the relations and a first numerical check of them.
The relationship between palynological diversity and floristic diversity was studied on the basis of sediment surface sample pollen data from nine small lakes and vegetation data within a 250 m radius from the lake shore of each. The nine study areas are situated in the patchy cultural landscape of Southern Estonia and were chosen to represent landscape changes along a gradient from closed forest
Background: Recent knowledge in animals suggests that gut microbial metabolism may affect host metabolism, including appetite regulating hormones. The aim of the present study was to evaluate the potential effects of a whole grain barley kernel product, rich in intrinsic indigestible carbohydrates (dietary fibre and resistant starch), on markers of metabolism and appetite regulation in healthy sub
In this essay, I scrutinize the interpretation of miracles advanced by Ayatollah Motahhari (1920-1979), the well-known Shi'a scholar; and Mehdi Golshani (1939-), a physicist and philosopher of science. The essay begins with a presentation of their viewpoints on the nature of miracles in the light of the broader philosophical discourse on the nature of miracles. This is followed by a comparative an
A study of 45 pool fire tests is presented in this paper. All tests have been conducted in the same experimental setup but with four different ventilation scenarios. The experimental setup consisted of a three-room compartment connected to a stairway. The tests have been conducted during a 6-year period under slightly different ambient conditions. The purpose of this paper is to study and quantify
General problem of extracting intramolecular energy transfer information from fluorescence and fluorescence excitation polarization experiments at single molecule level is presented. A single funnel approximation is shown to be a very powerful approach to model the polarization data obtained by recently emerged 2-dimensional polarization single molecule imaging technique [O. Mirzov et al., Small 5
Background/objectives: Adequate mineral intake is important for the maintenance of bone health, cellular function and general metabolism, and possibly in the aetiology of cancer and other chronic diseases. This study aimed at investigating variation in intakes of selected minerals across 10 European countries participating in the EPIC (European Prospective Investigation into Cancer and Nutrition)
Background: Calcitonin gene-related peptide (CGRP) has a key role in migraine pathophysiology and is associated with activation of the trigeminovascular system. The trigeminal ganglion, storing CGRP and its receptor components, projects peripheral to the intracranial vasculature and central to regions in the brainstem with A delta- and C-fibers; this constitutes an essential part of the pain pathw
In embryonic stem cells, removal of oxidatively damaged proteins is triggered upon the first signs of cell fate specification but the underlying mechanism is not known. Here, we report that this phase of differentiation encompasses an unexpected induction of genes encoding the proteasome activator PA28 alpha beta (11S), subunits of the immunoproteasome (20Si), and the 20Si regulator TNF alpha. Thi
