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Researchers from Lund Stem Cell Center have identified a novel target for the expansion of human blood stem cells ex vivo and shed light on the mechanism of action of a stem cell promoting molecule, currently in phase II clinical trials. Hematopoietic stem cell transplantation is a curative therapy for many patients suffering from life threatening blood disorders. This treatment is currently limit

https://www.medicine.lu.se/article/new-insights-ex-vivo-expansion-transplantable-human-blood-stem-cells - 2025-10-09

Neuroscientists and stem cell researchers at Lund University in Sweden have developed a research model that allows studying human hippocampal neurons, the brain cells primarily affected by Alzheimer’s disease pathology. The study has been published in Stem Cell Reports. In Alzheimer’s disease the hippocampus, a brain structure that regulates motivation, emotion, learning, and memory, is severely a

https://www.medicine.lu.se/article/new-research-paves-way-developing-therapies-could-slow-down-alzheimers - 2025-10-09

Researchers at Lund University in Sweden have discovered a new method to treat human herpes viruses. The new broad-spectrum method targets physical properties in the genome of the virus rather than viral proteins, which have previously been targeted. The treatment consists of new molecules that penetrate the protein shell of the virus and prevent genes from leaving the virus to infect the cell. It

https://www.medicine.lu.se/article/antiviral-method-against-herpes-paves-way-combatting-incurable-viral-infections - 2025-10-09

A new blood test demonstrated remarkable promise in discriminating between persons with and without Alzheimer’s disease and in persons at known genetic risk may be able to detect the disease as early as 20 years before the onset of cognitive impairment, according to a large international study published today in the Journal of the American Medical Association (JAMA) and simultaneously presented at

https://www.medicine.lu.se/article/new-blood-test-shows-great-promise-diagnosis-alzheimers-disease - 2025-10-09

A new and promising approach for treatment of lung cancer has been developed by researchers at Lund University. The treatment combines a novel surgical approach with smart nanoparticles to specifically target lung tumors. The new study has been published in the July issue of Advanced Therapeutics. Lung tumors are often difficult to remove using current surgical techniques due to their location in

https://www.medicine.lu.se/article/new-promising-treatment-uses-smart-nanoparticles-target-lung-cancer - 2025-10-09

Around 20,000 people have been diagnosed with Parkinson's disease in Sweden. Today, there is no imaging method of changes in the brain that are believed to cause the disease. Researchers at Skåne University Hospital and Lund University have received nearly SEK 7 million from the Michael J Fox Foundation to develop an imaging technique that can more accurately detect and track the development of Pa

https://www.medicine.lu.se/article/millions-michael-j-fox-foundation-improve-diagnosis-parkinsons - 2025-10-09

Prof. Johan Jakobsson and Assoc. Prof. Agnete Kirkeby from Lund Stem Cell Center and University of Copenhagen, along with co-applicants Prof. Roger Barker from Cambridge, UK and Assoc. Prof. Molly Hammell from Cold Spring Harbour Laboratory, US, have been awarded a prestigious grant from the Aligning Science Across Parkinson’s initiative. Using this funding they will investigate the role transposa

https://www.medicine.lu.se/article/researchers-investigate-role-transposable-elements-neuroinflammation-and-parkinsons-disease - 2025-10-09

The University Board has today decided to recommend the dean of the Faculty of Medicine, Erik Renström, as the new vice-chancellor of Lund University for the term of office 2021 to 2026. "This is a big step. I am humble and it is with deep respect I am looking forward to this task", comments Erik Renström.He is also highlighting that the definitive decision from the Swedish Government is yet not t

https://www.medicine.lu.se/article/erik-renstrom-proposed-new-vice-chancellor - 2025-10-09

Johan Richter's research has resulted in the successful development of gene therapy for the hereditary disease malignant infantile osteopetrosis. For the past few years, the research group has established a collaboration with an American biotech company and all the permits needed to start a clinical trial have now been obtained. Every year in Sweden a child is born with the unusual skeletal diseas

https://www.medicine.lu.se/article/successful-biotech-collaboration-brings-gene-therapy-project-clinic - 2025-10-09

Metformin is the first-line drug that can lower blood sugar levels in type 2 diabetes patients. One third of patients do not respond to metformin treatment and 5 per cent experience serious side effects, which is the reason many choose to stop medicating. Researchers at Lund University in Sweden have now identified biomarkers that can show in advance how the patient will respond to metformin treat

https://www.medicine.lu.se/article/metformin-type-2-diabetes-patients-or-not-researchers-now-have-answer - 2025-10-09

A large proportion of our elite athletes are suffering psychological distress during the COVID-19 pandemic, with more women than men reporting adverse reactions. This is demonstrated by the study Psychological Distress and Problem Gambling in Elite Athletes during COVID-19 Restrictions: A Web Survey in Top Leagues of Three Sports during the Pandemic, published in the International Journal of Envir

https://www.medicine.lu.se/article/many-elite-athletes-feeling-psychological-distress-during-pandemic - 2025-10-09

Lund University researchers have developed an analytical model that can effectively detect and identify gene mutations in breast tumours. In the study, which is the largest of its kind anywhere in the world, they are now reporting results from 3,200 breast cancer patients. To assist them, they have utilised a technique known as RNA sequencing, a sensitive and precise tool that, while it is slowly

https://www.medicine.lu.se/article/new-analytical-method-benefits-breast-cancer-patients - 2025-10-09

A drug has shown great promise in the treatment of neuroblastoma, an aggressive form of childhood cancer. The study was led by researchers at Lund University in Sweden, and is published in the journal Science Translational Medicine. Every year, about 20 children in Sweden are diagnosed with neuroblastoma, an aggressive cancer of the nervous system that most frequently arises in the adrenal glands.

https://www.medicine.lu.se/article/promising-treatment-aggressive-childhood-cancer - 2025-10-09

Agnete Kirkeby is working to repair the brain with stem cells. “The goal of our research is to understand how the human brain is formed and how it functions. And how we can repair it by generating new cells in the lab.” Agnete Kirkeby is one of the reserchers at Wallenberg Centre for Molecular Medicine at Lund University (WCMM LU). This autumn, every week, we present a fellow at the center.WCMM at

https://www.medicine.lu.se/article/meet-weeks-wallenberg-researcher-agnete-kirkeby - 2025-10-09

Should patients with separate variants of type 2 diabetes be treated with different types of drugs? Researchers at Lund University in Sweden and Skåne University Hospital will attempt to answer that question in a new study. Type 2 diabetes is one of the fastest growing diseases in the world. It is estimated that over 300 million people have the disease globally.“Current treatment methods are unfor

https://www.medicine.lu.se/article/new-study-personalized-type-2-diabetes-treatment-launched - 2025-10-09

Niklas Mattsson-Carlgren is searching for underlying causes for Alzheimer’s Disease. “I am motivated by the possibility that my work may make difference for patients with Alzheimer’s Disease.” Niklas Mattsson-Carlgren is one of the reserchers at Wallenberg Centre for Molecular Medicine at Lund University (WCMM LU). This autumn, every week, we present a fellow at the center.WCMM at Lund University

https://www.medicine.lu.se/article/meet-weeks-wallenberg-researcher-niklas-mattsson-carlgren - 2025-10-09

Nicholas Leigh is studying how other organisms have solved biological problems “The idea is that by understanding how other species are able to, for instance, regenerate a limb, we could help promote regeneration in humans.” Nicholas Leigh is one of the researchers at Wallenberg Centre for Molecular Medicine at Lund University (WCMM LU). This autumn, every week, we present a fellow at the center.

https://www.medicine.lu.se/article/meet-weeks-wallenberg-researcher-nicholas-leigh - 2025-10-09

In a collaborative study, researchers from Lund Stem Cell Center and University College London have developed a novel method of isolating ‘young’ stem cells still present in old mice. They show that activity of mitochondria, the power generators of the cell, is a stronger indicator of stem cell fitness than age and is a potential therapeutic target for the treatment of age associated disease. The

https://www.medicine.lu.se/article/novel-approach-identifies-young-stem-cells-old-mice - 2025-10-09

Researchers at Lund University in Sweden studied self-grooming rats in order to better understand how the brain chooses what comes next in a sequence of actions. The study shows that when they switch from one action to the next in the grooming chain, the signalling in different parts of the brain changes. The results, published recently in Science Advances, increase understanding of which processe

https://www.medicine.lu.se/article/self-grooming-rats-offered-clues-how-brain-chooses-behaviour - 2025-10-09

Paul Bourgine is studying skeletal tissue regeneration. “We study how human bones form, regenerate and how they function as a blood production center and use this knowledge for the design of specific regenerative therapies” Paul Bourgine is one of the researchers at Wallenberg Centre for Molecular Medicine at Lund University (WCMM LU). This autumn, every week, we present a fellow at the center. WC

https://www.medicine.lu.se/article/meet-weeks-wallenberg-researcher-paul-bourgine - 2025-10-09