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Objectives: Current therapeutic strategies for essential thrombocythemia (ET) are mainly considered to prevent thrombo-hemorrhagic events, without increasing the rate of fibrotic progression or leukemic evolution. To treat the patients appropriately, the precise diagnosis of ET is essential. Although approximately 30% of ET cases are diagnosed as CALR mutation-positive; commercially available poly
The surface chemistry of mesoporous nickel oxide (NiOx) plays a pivotal role in its functionality across various technological applications. Herein, we present a detailed study of NiOx surface states using multiple spectroscopic techniques, including ambient pressure X-ray photoelectron spectroscopy (XPS), ultraviolet-visible (UV-vis) spectroscopy, and Fourier-transform infrared (FTIR) spectroscop
The last mute film in Carl Th. Dreyer’s oeuvre, The Passion of Joan of Arc (1928), is often referred to as a film “made of close-ups” and purely cinematic. Dreyer used to stress himself that close-up was the specific cinematic device that asserted film’s position as autonomous art. He especially insisted on film’s independence from theatre. Thus, it might sound quite surprising that in an intervi
Industrial sector, by boosting energy efficiency and reducing waste through the use of digital twin (DT) technology in the integration of industrial IoT (IIoT). DT generates realistic simulations for predictive analytics and decision-making with the help of real-time simulations of physical objects. In this chapter, the authors focus on the DT application for the optimum utilization of energy and
Adaptive haptics, an amalgamation of different haptic systems and machine learning algorithms, has the potential for intelligent feedback in healthcare. Such systems are capable of learning to suit individual user needs in real-time, thereby improving patient care, medical education, and treatment. Targeted techniques of machine learning approaches are reinforcement learning, neural networks, supp
Self-compassion is associated with positive mental health outcomes and may buffer against negative self-evaluations and emotional difficulties. Nevertheless, studies among athletes often explore self-compassion in specific groups in isolation (e.g., women athletes) (Röthlin et al., 2019). The aims of this study were to 1) explore whether the relationship between gender and composite scores and spe
INTRODUCTION: Plasma phosphorylated tau (p-tau)181, glial fibrillary acidic protein (GFAP), neurofilament light chain (NfL), and amyloid beta ratio (Aβ42/40) may have diagnostic and prognostic value in Alzheimer's disease (AD). Here we assess which markers can best identify AD from controls and other non-AD dementias in a large international multi-center study. METHODS: Plasma samples (n = 1298) w
Although leuprorelin acetate, a luteinizing hormone-releasing hormone agonist, has been approved based on short-term clinical trials conducted in Japan, its long-term efficacy on physical function remains unclear. We aimed to evaluate the long-term therapeutic efficacy of leuprorelin acetate using real-world clinical data through a self-controlled trend-shift analysis. The analysis included 91 gen
A hybrid assistive limb (HAL) can improve the motor performance of patients with various neurodegenerative diseases, but the efficacy of home-based rehabilitation using HAL for spinocerebellar ataxias (SCA) has yet to be elucidated. To evaluate the efficacy and safety of home-based telerehabilitation with lumbar type HAL in patients with SCA. In this non-randomized open-label single center trial,
Chemical defences, such as the monoterpenes of conifer oleoresin, frequently occur as complex blends of many components, but the selective pressures that maintain these mixtures are not yet known. Several theories attempt to explain the existence of chemical defence mixtures in plants. However, due to limited empirical evidence, it is unclear which theories might best apply. Here, we tested the va
BACKGROUND: Artificial intelligence may improve diagnostic yield and accuracy in syncope.OBJECTIVES: The purpose of this study was to compare Generative Pretrained Transformer 4-Omni (GPT-4o) with medical professionals (MPs) in establishing syncope diagnoses and recommending interventions based on general practitioner's referral letters to a syncope-unit.METHODS: This three-phase study evaluated 5
The Swedish Constitution consists of four constitutional acts, and one of them is the Instrument of Government (Regeringsformen). It was enacted in 1974 and entered into force 1st January 1975. This year, it has functioned as the most important constitutional act in Sweden for 50 years. Its name, the Instrument of Government, was used for the first time in 1634, when a constitutional act was issue
Erik Olin Wright (1947–2019) var en amerikansk samhällsforskare, disputerad i sociologi och engagerad i marxistiska frågor om ojämlikhet, förtryck och möjligheterna till frigörelse genom samhällsomvandling. Hans svar var långt ifrån alltid renläriga, och att Wright inte såg något egenvärde i att noga hålla sig inom en viss tanketradition är kännetecknande för hans akademiska arbete. Själv beskrev
BackgroundLarge-scale genomic rearrangements in cancer cells can lead to the creation of fusion genes which alter the expression or function of the partner genes. Some fusion genes act as tumour drivers and the use of kinase inhibitors in patients with specific fusions have led to breakthroughs in cancer therapy. The large clinical and scientific interest in fusions has led to the development of s
Coastal eutrophication results from increased riverine loads of inorganic nutrients, including phosphorus (P), which may co-occur with increased dissolved organic carbon (DOC) loading. These DOC molecules are often pigmented, causing water darkening, but they also contain dissolved organic P (DOP), which could exacerbate eutrophication. However, it is unclear how the bioavailable DOP (BDOP) pool r
