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The design and development of drugs which can permeate the blood brain barrier (BBB) for the treatment of hard-to-treat central nervous system (CNS) diseases is a critical and prevalent challenge in medicinal chemistry. Such diseases include Alzheimer’s Disease (AD) and Parkinson’s Disease (PD) - both chronic and progressive neurodegenerative disorders affecting the brain. Galectin-3 (gal-3) is a
Galectins are small, carbohydrate-binding proteins widely distributed among different cells and tissues in the human body. Due to their abundance, these proteins are involved in many processes and diseases. Among the different types of galectins found in the human body, galectin-1 and galectin-3 are the most common, thus the most targeted and studied. Particularly, galectin-3 is the only chimeric
This thesis investigates whether intermediate and advanced Swedish learners of Japanese language can use prosodic cues—particularly pitch-based features such as downstep—to differentiate between structurally ambiguous noun phrases, specifically those having both left branching (LB) and right branching (RB) interpretations, in spoken Japanese in the same way as native speakers. It also examines
Hälso- och sjukvården påverkar dagens miljö och som operationssjuksköterska med användning av olika kirurgiska instrument såsom engångs-, flergångs och hybridinstrument samt material. Instrument packas upp, används och antingen slängs i onödan eller behöver gå tillbaka till steriliseringsprocessen. Operationssjuksköterskan bör vara medveten om kirurgiska instruments miljöpåverkan, resursförbruknin
This thesis explores how disaster-affected communities in the Kavre and Bardiya districts of Nepal perceive and experience cash assistance projects. The research was guided by two core questions: (1) What are community members' perceptions and preferences of cash assistance in disaster affected areas in the Kavre and Bardiya districts of Nepal? (2) How could these community perceptions and pre
This bachelor’s thesis explores how everyday users, specifically non-experts in higher education, interact with AI-based chatbots through natural language prompts. While prior research has focused on improving model performance and understanding prompt mechanics, little attention has been given to how users without technical expertise experience and shape these interactions. The study aimed to exp
How do event-by-event temperature fluctuations in the quark–gluon plasma alter jet- quenching signatures? This thesis answered that question by using the simulation tool JEWEL with two different medium models. The first one was a more realistic, event-by- event ”lumpy” temperature profile in the plasma. The second one treated the medium as a smooth, average background instead. Jet quenching is the
The bachelor’s thesis explores end-customers’ perceptions regarding the differences between AI-based and human customer service, and the interaction factors that influence their experi-ences. With a focus on customer satisfaction and perceived problem-solving, the study aims at providing recommendations for the development and design of AI chatbots to better meet customer expectations and satisfac
The introduction of private label brands (PLBs) have transformed the landscape of grocery retail, challenging the dominance of manufacturer brands (MBs) and redrawing the lines of in-store competition. As shelf space plays a critical role in shaping consumer behavior at the point of purchase, this study investigates whether Swedish grocery retailers allocate shelf space to PLBs in ways that exceed
Monitoring of human motion classification provides several opportunities to aid the process of rehabilitation, exercise logging and much more. In this thesis, Inertial Measurement Unit (IMU) devices positioned on different body parts are used to collect accelerometer and gyroscope data. This data is then combined to predict what gym exercise is being performed by the user. Different architectures
This thesis examines how public discourse in Nigeria reflects the drivers behind Bitcoin adoption. Using thematic analysis of Nigerian newspaper articles from 2020 to 2025, the study identifies three key themes: economic instability, political resistance, and financial inclusion. Through the lens of Austrian economic theory, especially Hayek’s idea of currency competition, Bitcoin adoption is inte
Following the discontinuation of LIBOR, the interest rate market has transitioned to backward-looking benchmarks such as SOFR. Unlike traditional forward-looking rates like LIBOR, SOFR is set in arrears, which affects the pricing methods of derivatives linked to these benchmarks. This thesis studies the impact of this transition on the pricing and calibration of caps within the Hull-White framewor
Föreliggande examensarbete ämnar belysa och problematisera lyssneläsningsbegreppet utifrån den mediala debatten i Svenska Dagbladet och genom intervjuer av tre specialpedagoger och tre svensklärare på gymnasial nivå. Syftet innefattar att lyfta fram olika erfarenheter och framställningar av lyssneläsning med tematisk ingång för att sedan diskutera möjliga didaktiska implikationer. Resultaten visar
Syfte: Studiens syfte är att utreda hur dagligvarukedjorna ICA, Axfood och Coop använder account-strategier i sina VD-ord för att skapa och upprätthålla legitimitet. Metod: Med utgångspunkt i en kvalitativ metod har de fem senaste VD-orden från aktörerna analyserats för att undersöka hur legitimitet skapas. Analysmodellen har utformats med Gioia et al:s (2013) riktlinjer för kvalitativ forskning,
Juvenile idiopathic arthritis (JIA) is the most common rheumatic disease in children and is characterized by chronic synovial inflammation. Monocytes isolated from inflamed joints in oligoarticular JIA display both inflammatory and regulatory features. While some insights exist regarding signals that drive regulatory traits, the mechanisms responsible for inflammatory activation remain poorly unde
Biometric fingerprint recognition is a cornerstone of modern authentication systems, yet conventional convolutional neural network approaches often struggle with challenging cases, subjected to noise and partial overlap. This thesis explores the potential of transformer-based architectures to address these challenges. We design, implement, and evaluate five models on a large-scale dataset of over
Denna kandidatuppsats undersöker hur digitala möten påverkar kommunikation och samarbete inom remote-first-företag. I takt med att arbetslivet blivit alltmer digitaliserat, särskilt efter pan-demin, har digitala möten etablerat sig som en central del av det dagliga arbetet. Uppsatsen syftar till att belysa hur denna förändring påverkar de anställdas sätt att samarbeta och kommunicera samt vilka ut
In 2023, an in situ 4-dimensional high resolution synchrotron X-ray Tomography was used to image an experiment in which paper strips were immersed in different liquids. The paper strip material is the same that is used in the fabrication of paper straws at Tetra Pak. In this thesis, this data is used to analyse and model the interactions between the liquid and the paper at the individual fibre lev
Hirschsprung’s disease is a rare, congenital disease characterized by a lack of nerves in parts of the gastrointestinal tract. The disease is often diagnosed early in a child’s life, as the lack of nerves inhibits the passing of stool. Surgery is required to remove the affected part of the intestine. Today intra-operative biopsies are taken to determine where the diseased part of the intestine end
