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Cancer progression is profoundly influenced by the dynamic interactions between cancer cells and their surrounding tumour microenvironment (TME). A defining feature of the TME is the progressive remodelling of the extracellular matrix (ECM), which becomes stiffer and structurally altered during disease progression. These changes regulate cell behaviour and contribute to tumour growth, invasion and
Epidemiological studies suggest an association between Parkinson’s disease (PD) and ulcerative colitis (UC), yet the molecular programs potentially linking these disorders remain poorly defined. Here, we integrated curated disease-gene resources with publicly available blood transcriptomic datasets to identify shared molecular features across PD and UC. We identified 320 shared signature genes and
Research concerning digital engagement among older adults frequently frames technology use in terms of access deficiencies and skill gaps and emphasises the need for training and inclusion initiatives. Additional research underscores how self-efficacy, ageism, COVID-19 and the emergence of assistive technologies influence everyday adoption practices. This chapter builds upon these perspectives whi
The APOE locus is the strongest genetic factor for Alzheimer’s disease, with ε4 increasing and ε2 decreasing risk, yet the basis of these opposing effects remains unclear. Here we performed a multicohort proteomic analysis across plasma and cerebrospinal fluid in GNPC, BioFINDER-2, ADNI, UK BioBank, and PPMI. APOE-associated protein alterations are detectable before amyloid pathology and remain st
Understanding and controlling light-driven electronic processes at the nanometer scale is important for the continued development of next-generation optoelectronic devices, energy-efficient information processing, and emerging neuromorphic systems. This thesis investigates light-matter interactions in nanoscale systems across a broad range of timescales, from femtosecond plasmon dynamics to molecu
We present the combined JWST/NIRSpec/G395H and NIRISS/SOSS transmission spectrum of a warm mini-Neptune, TOI-1130 b (3.66 R⊕, 19.8 M⊕, and Teq ∼ 825 K). It is part of a rare and unique multiplanet system, TOI-1130, which hosts an inner mini-Neptune and an outer hot Jupiter locked in a 2:1 mean motion resonance. From the transmission spectrum of TOI-1130 b we detect multiple molecules—H2O (7.5σ), C
OBJECTIVES: To explore the possible effects of intensive care follow-up visits and diaries on patients physical and psychosocial problems at 2, 6, and 12 months after unit discharge as well as the patient' experiences of follow-up visits and diaries.METHODS: A descriptive and explorative cohort design. Patients (n = 441) with a length of ICU stay for ≥24 hours, who responded to the 3-set 4P questi
Doughnut Economics has become an important model for planning, often assumed to offer a better, more sustainable approach. This article engages with such assumptions by critically interrogating the radical potential of doughnut planning. It does this through examining the doughnut diagram, which conceptualizes core ideas of Doughnut Economics, and by relating these to discussions in planning. The
This project addresses the precision challenges in robot–human handover processes, particularly in surgical environments. Two different approaches are explored: (1) learning from a few human demonstrations with hand and instrument tracking and (2) collecting data from remotely controlled robot movements using a joystick or VR system. The aim is to achieve precise, natural handovers without requiri
In numerical combustion research, accurate chemical reaction mechanisms for heavy hydrocarbons are essential to investigate the flame dynamics of sustainable aviation fuels (SAF) relative to conventional jet fuels. However, accounting for hundreds or thousands of reactions makes finite-rate chemistry (FRC) large-eddy simulations (LES) impractical for realistic engineering scenarios. Here, a multid
Sufficiency policies address unsustainable consumption and production patterns by promoting ways of living and economies that prioritize “enough” over “more,” reducing resource use while safeguarding fundamental human needs. Public support is crucial for the effective implementation of sufficiency policies, yet empirical research on citizens' preferences and their underlying mechanisms remains sca
Multiple choice question tests are often the gateway to important professional outcomes. We study gender differences in willingness to guess among highly skilled and trained candidates in a high stakes multiple choice question test, before and after a reduction in the number of alternative answers to each question, lowering the penalty for incorrect answers to the critical value, i.e, the one yiel
Background: PERK (Protein kinase R-like endoplasmic reticulum kinase), encoded by EIF2AK3, is a key ER stress sensor that regulates protein synthesis and the unfolded protein response (UPR). Its dysregulation is linked to cancer development and progression. This study investigated EIF2AK3/PERK expression across 28 tumour types (n = 7,251) and their matched normal adjacent tissues (NATs; n = 667) f
Abstract – Although electroencephalography (EEG) is used to assess neonatal pain in research settings, EEG assessments have not been sufficiently characterized for use as end points to assess the efficacy of analgesics in regulatory-endorsed, industry-sponsored trials. We aimed to identify all studies conducted in neonates with EEG recordings during acute somatic nociceptive skin-breaking procedur
The Routledge International Handbook of Research Security examines research security - the act of protecting and securing university research and teaching in the name of national security - through a multidisciplinary and comparative lens. In this volume, contributors explore theoretical, domestic, international, and practical pursuits of research security across the globe. Over six sections, the
Beamstopper-Integrated Sensors (BIS) based on silicon carbide (SiC) represent a novel class of compact, radiation hard devices that combine beam interception with real-time diagnostics. We present the first characterization of four-quadrant BIS designed for simultaneous intensity and position monitoring on synchrotron beamlines. Based on the established reliability of single-pixel BIS as intensity
Building on the extensive literature on colonial rural capitalism, particularly characteristic of Western Africa, this paper examines African small-scale entrepreneurship within a more diversified yet simultaneously more discriminative economy of Kenya. It contributes to the relatively scarce literature on historical African entrepreneurship by investigating different forms of formal sector entrep
