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n this paper I will use concepts from innovation theory to analyse the work of the Court of Justice of the European Union in its important role as sole interpreter of EU law. In that regard, I define ‘innovator’ as one that facilitates use of new or existing inventions. Thus innovation is portrayed as a process in which several actors may contribute and where it all starts with an invention (the s
Older people with arrhythmias comprise a large group requiring complex care, posing many healthcare challenges. Rapid growth of the older population demands a better understanding of the needs of this patient group. The aim of this thesis was to investigate arrhythmia prevalence, incidence, survival, and experiences from the perspective of a geriatric population (aged 60+ years), and to examine th
Jordan population have increased 3 million in the last five years. 1.5Million are refugees from Syria. 800 thousand are inside refugeecamps in the northern part of Jordan. 100 thousand are situated inZaatari camp which is located 10 kilometres east of Mafraq city. Thisenormous influx increased solid waste volume generated by 480 tonsdaily. The additional waste generation has exacerbated pre-existi
The present study uses RSM (Response Surface Methodology) to verify the fusibility of bottom ash from coal industry, and efficient flux between, calcium oxide (CaO), lithium oxide (Li2O) and sodium oxide (Na2O). The bottom ashes,have demonstrated the possibility to be used in the development of glass-ceramics, and glassy materials, due to the presence of high concentrations of aluminum silicates.
Semiconductor nanowires show a great deal of promise for applications in a widerange of important fields, including photovoltaics, biomedicine, and informationtechnology. Developing these exciting applications is strongly dependent onunderstanding the fundamental properties of nanowires, such as their opticalresonances and absorption spectra. In this thesis we explore optical absorption spectra of
Mitochondrial biogenesis and function in plants require the expression of over 1000 nuclear genes encoding mitochondrial proteins (NGEMPs). The expression of these genes is regulated by tissue-specific, developmental, internal, and external stimuli that result in a dynamic organelle involved in both metabolic and a variety of signaling processes. Although the metabolic and biosynthetic machinery o
Upon disturbance of their function by stress, mitochondria can signal to the nucleus to steer the expression of responsive genes. This mitochondria-to-nucleus communication is often referred to as mitochondrial retrograde regulation (MRR). Although reactive oxygen species and calcium are likely candidate signaling molecules for MRR, the protein signaling components in plants remain largely unknown
Plants require daily coordinated regulation of energy metabolism for optimal growth and survival and therefore need to integrate cellular responses with both mitochondrial and plastid retrograde signaling. Using a forward genetic screen to characterize regulators of alternative oxidase1a (rao) mutants, we identified RAO2/Arabidopsis NAC domain-containing protein17 (ANAC017) as a direct positive re
The expression of a variety of nuclear genes encoding mitochondrial proteins is known to adapt to changes in environmental conditions and retrograde signaling. The presence of putative WRKY transcription factor binding sites (W-boxes) in the promoters of many of these genes prompted a screen of 72 annotated WRKY factors in the Arabidopsis (Arabidopsis thaliana) genome for regulators of transcripts
Throughout the life of a plant, the biogenesis and fine-tuning of energy organelles is essential both under normal growth and stress conditions. Communication from organelle to nucleus is essential to adapt gene regulation and protein synthesis specifically to the current needs of the plant. This organelle-to-nuclear communication is termed retrograde signaling and has been studied extensively ove
