Aging and aging-related neurodegenerative disorders, such as Alzheimer’s disease, are characterized by chronic inflammation that progressively damages nervous tissue within the central nervous system (CNS). In addition to cytokines, lectin-like carbohydrate recognition molecules play a critical role in modifying cellular communication during inflammation. Among these, galectins—particularly anti-i

Objectives: This is a protocol for a Cochrane Review (intervention). The objectives are as follows:. To assess the benefits and harms of motor interventions initiated prior hospital discharge to prevent neurodevelopmental and motor impairment in preterm infants compared to standard care, post-discharge motor interventions, and different modalities of the same motor intervention.

We report on an exact theory for ensembles of globally coupled, heterogeneous complex Riccati equations. A drastic dimensionality reduction to a few ordinary differential equations is achieved for Lorentzian heterogeneity. By applying this technique, we obtain low-dimensional firing-rate equations for populations of spiking neurons with a clustered substructure.

In recent years, new contributors to the marine silica cycle have emerged, including pico-sized phytoplankton (3 µm) in the dissolved silica-replete Baltic Sea via biweekly time series samplings spanning 2 years. Time series data showed that the large changes in bSi standing stock in the Baltic Proper were primarily related to microplankton biomass and community composition. Meanwhile, picoplankto

It is becoming clear that the cognition of a species plays an important role in successful conservation, with cultural processes being a fundamental part of this. However, in contrast to mammals and birds, very little is known about cultural processes (and the social learning that underlies these) in reptiles. Here, we summarize the current state of knowledge, consider why this information is so l

Chromosomal translocations are key events in cancer, driving oncogenesis by disrupting and deregulating critical genes. While specific tumor-associated translocations are well studied, the frequencies and distributions of most remain unknown. Additionally, the role of chromosomal reshuffling in translocations has received little attention. This study presents data on the chromosomal involvement in

The aim of this study was to investigate the impact of phenol on the precipitation of bovine serum albumin (BSA) and human growth hormone (hGH), in the presence of other excipients frequently used in biological drugs for parenteral delivery. The focus of the study lieson incompatibilities observed in multidose formulations containing non-ionic surfactants and preservatives. Previous research has s

Background: Data in Ethiopia on the epidemiology of Respiratory Syncytial Virus (RSV) and subtypes among influenza-like illness (ILI) and severe acute respiratory infections (SARI) cases is limited. Here, we assessed the epidemiology of RSV and its subtypes among the pediatric and adult ILI /SARI cases in Ethiopia. Methods: We conducted prospective, multicenter facility-based study from May 2023 t

BACKGROUND: Patients presenting with an acutely painful swollen joint represent a diagnostic challenge. We aimed to develop a clinical prediction model for septic arthritis (SA) in the adult native knee.METHODS: We screened all synovial cultures in south Sweden in 2020 and 2021. We included cultures taken in the emergency department from adults' native knees where SA was considered a differential

Establishing robust charging infrastructure is crucial for electric vehicle (EV) adoption. This study addresses the lack of systematic literature reviews examining the global charging infrastructure research landscape with a comprehensive review of English literature published between 2017 and 2023. We screened 12237 records, and analyzed 137 peer-reviewed and 31 grey literature studies. Findings

Combined density functional theory (DFT) and X-ray standing wave (XSW) studies have previously provided evidence for the preferential adoption of an inverted conformation of 2H-TPP on Cu(111) in contrast to the saddle conformation usually favored by porphyrin molecules adsorbed on metals. We experimentally demonstrate, via X-ray photoelectron spectroscopy (XPS) analysis, that the binding energies

Cancer cells in solid tumors experience hypoxia, a condition of low O2 concentration, since their O2 demand exceeds the supply from the surrounding vasculature. However, how these cells adapt to hypoxia requires further elucidation. Here, we use a transparent phosphorescent thin film to visualize the self-generated hypoxia field of prostate cancer cells and quantify local O2 consumption rates, mea

The Swedish Research Council is a Swedish government agency and one of the major research financiers in Sweden. As such, its operations are governed by legislation and governmental instructions and policies, which prohibit discrimination and include equal treatment. Consequently, the Swedish Research Council has for a large number of years been working actively against gender bias in their reviews

Background and purpose: The recently published Nordic anal cancer group (NOAC) contouring guidelines aim for improved oncological outcomes and reduced toxicity in anal cancer patients treated with radiotherapy. The present work describes how the elective clinical target volume (CTVe) would change when applying the NOAC guidelines instead of the previous Australasian standard. According to the Aust

This case explores the interplay between commerce and colonial expansion through the lens of the Dutch East India Company (VOC) in the 17th century. Tasked with securing profit while navigating geopolitical rivalries, the VOC’s decision-makers faced dilemmas that blurred the lines between trade and conquest. This case places students in the role of the Heeren XVII, the governing board of the VOC,