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Climate and land use changes can increase terrestrial runoff to aquatic systems, leading to brownification and eutrophication in northern boreal lakes. Brownification may boost bacterial respiration and production, while eutrophication can enhance primary production and algal blooms. However, their combined effects on basal producers and bacterial carbon utilization are less understood. This study
Apidaecin 1b (Api), the first characterized Type II Proline-rich antimicrobial peptide (PrAMP), is encoded in the honey bee genome. It inhibits bacterial growth by binding in the nascent peptide exit tunnel of the ribosome after the release of the completed protein and trapping the release factors. By genome mining, we have identified 71 PrAMPs encoded in insect genomes as pre-pro-polyproteins. Ha
Clustering multiple motions from observed point trajectories is a fundamental task in understanding dynamic scenes. Most motion models require multiple tracks to estimate their parameters, hence identifying clusters when multiple motions are observed is a very challenging task. This is even aggravated for high-dimensional motion models. The starting point of our work is that this high-dimensionali
Studies exploring the hippocampal subfield atrophy in Alzheimer’s disease (AD) have shown contradictory results. This review aims to disentangle such heterogeneity by investigating the dynamic changes of hippocampal subfields across the AD continuum. We systematically searched the PubMed and EMBASE databases for case-control studies. Selected studies included investigations of biomarker-based amyl
As a concept, agency stretches from philosophical and meta-theoretical elaborations to studies documenting largely idiosyncratic happenings in a particular empirical context, which could be dismissed as anecdotal. In between, and the source for the recent revival of scholarly interest, lies the promise to explain transformation processes, multiplex governance, and varieties in wellbeing and develo
Lund University (Sweden) teacher education students' reflections constitute the foundation for this chapter. The students wrote about their situation, what they could learn from it and how they could bring these lessons into their future roles. The students' voices on digitalisation and isolation in their learning experiences illustrate the importance of belonging and motivation in education. The
We present here the genomic structures for two genes implicated in craniofacial development. Retinoic acid receptor alpha (RARA), or a gene in its vicinity, has been implicated in non-syndromic cleft lip and palate, based on both association and linkage studies. Using primers directed to the 3' -UTR of the published cDNA sequence, we screened a human genomic BAC library to obtain a clone containin
BACKGROUND: Respiratory syncytial virus (RSV) and influenza cause significant health challenges, particularly for individuals with comorbid conditions and older adults. However, information on the clinical manifestations and outcomes of adults hospitalized with RSV in Europe remains limited.METHODS: This multicenter observational cohort study of adults hospitalized with RSV or influenza A or B fro
Complex metabolic diseases due to overnutrition such as obesity, type 2 diabetes, and fatty liver disease are a major burden on the healthcare system worldwide. Current research primarily focuses on disease endpoints and trying to understand underlying mechanisms at relatively late stages of the diseases, when irreversible damage is already done. However, complex interactions between physiological
BACKGROUND: Self-reported mental stress is not consistently recognized as a risk factor for stroke. This prompted development of a novel algorithm for stress-phenotype indices to quantify chronic stress prevalence in relation to a modified stroke risk score in a South African cohort. The algorithm is based on biomarkers adrenocorticotrophic hormone, high-density lipoprotein cholesterol, high-sensi
While hybridisation in vascular plants has received considerable attention, hybridisation in bryophytes is still relatively understudied. Here we investigate hybridisation between two species from the moss genus Dicranum Hedw. Dicranum scoparium Hedw. and D. bonjeanii De Not. are two moss species of the D. scoparium species complex with partially overlapping morphology and habitat ranges. This stu
Objectives Patients with type 2 diabetes mellitus (DM) run lower risk for abdominal aortic aneurysm (AAA, aortic diameter ≥ 30 mm) and its complications. We aimed to evaluate associations between disturbances in glucose metabolism and arterial stiffness, AAA, and abdominal aortic diameter in 65-year-old men. Methods Forty-eight 65-year-old men with screening-detected AAA and 115 men with normal ab
Satu Lähteenoja’s PhD thesis consists of five published articles and an extensive introduction. The articles make strong, or even major, contributions to research and Satu Lähteenoja’s contribution to the articles is clearly demonstrated. The introduction combines the articles into a whole and through the introduction the contribution is clearly bigger than the sum of the five articles.
Boreal and temperate forests are undergoing structural, compositional and functional changes in response to increasing temperatures, changes in precipitation, and rising CO2, but the extent of the changes in forests will also depend on current and future forest management. This study utilized the dynamic vegetation model LPJ-GUESS enabled with forest management (version 4.1.2, rev11016) to simulat
Background: Transcatheter aortic valve implantation (TAVI) has shown similar or improved clinical outcomes compared with surgical aortic valve replacement (SAVR) in patients with symptomatic severe aortic stenosis at low risk for surgical mortality. This cost-utility analysis compared TAVI with SAPIEN 3 versus SAVR in symptomatic severe aortic stenosis patients at low risk of surgical mortality fr
