The remote forcing from land surface changes in the Sahara is hypothesized to play a pivotal role in modulating the intensity of the East Asian summer monsoon (EASM) through ocean-atmospheric teleconnections. This modulation has far-reaching consequences, particularly in facilitating societal shifts documented in northern China. Here, we present a well-dated lake-level record from the Daihai Lake

Despite its proven societal value, humanities knowledge tends to be marginalized in research policy; this has been a topic of debate for some time. In this chapter, we focus on the valorization of humanities knowledge, with the aim of comprehending the way this process engenders societal impact. We argue that historical impact stories offer an effective methodological approach for a deeper underst

Background and Hypothesis: To clarify whether the familial liability to psychosis associated with bipolar disorder (BD) is nonspecific or has a greater effect on risk for psychosis in cases with prominent mood symptoms and/or a remitting course. Study Design: We examined, in 984 809 offspring raised in intact families in Sweden, born 1980-1996 and followed-up through 2018, by multivariable Cox pro

Security and sustainability are prioritized goals in the “Western liberal” world. Maintaining democratic resources while simultaneously strengthening society’s ability to deal with security issues firmly resonates with ideals associated with social sustainability. However, merging normative theories like security and social sustainability produces conceptual difficulties that are hard to resolve.

This chapter explores the alignment between the stated intention of Swedish Higher Education Institutions (HEIs) to matter and the assessment of individuals to matter. To achieve this aim, HEIs collaboration strategies are compared with the criteria for the guidance for merits regarding docentship. Our analysis reveals a notable disparity: the societal collaboration visions outlined in strategies

Background and objective: Phosphorylated tau (p-tau) 217 has recently received attention because it seems more reliable than other p-tau variants for identifying Alzheimer’s disease (AD) pathology. Thus, we aimed to compare the diagnostic accuracy of plasma and CSF p-tau217 with p-tau181 and p-tau231 in a memory clinic cohort. Methods: The study included 114 participants (CU = 33; MCI = 67; Dement

The identification of nonlinear chirp signals has attracted notable attention in the recent literature, including estimators such as the variational mode decomposition and the nonlinear chirp mode estimator. However, most presented methods fail to process signals with close frequency intervals or depend on user-determined parameters that are often non-trivial to select optimally. In this work, we

The interaction between our immune system and pathogens encompasses a complex spectrum from symbiosis to potentially life-threatening diseases. Throughout evolution, our immune system has evolved numerous strategies such as phagocytosis to combat infections and protect us from diseases. Phagocytosis involves the engulfment of pathogens by our immune cells and can be facilitated through opsonizatio

Filaggrin (FLG), a skin barrier protein, is associated with higher dermal uptake of some chemicals in carriers of loss-of-function (null) mutations. This study investigates FLG mutations and systemic effects following dermal exposure to chemicals. Individuals (n = 23 FLG null, n = 31 FLG wt) were simultaneously exposed to pyrimethanil, pyrene, oxybenzone, and nickel ions for 4 h. Pre- and post-exp

The Storage Location Assignment Problem (SLAP) has a significant impact on the efficiency of warehouse operations. We propose a multi-phase optimizer for the SLAP, where the quality of an assignment is based on distance estimates of future-forecasted order-picking. Candidate assignments are first sampled using a Markov Chain accept/reject method. Order-picking Traveling Salesman Problems (TSPs) ar

ObjectivesPre-treatment staging of anal squamous cell carcinoma (ASCC) includes pelvic MRI and [18F]-fluorodeoxyglucose positron emission tomography with computed tomography (PET-CT). MRI criteria to define lymph node metastases (LNMs) in ASCC are currently lacking. The aim of this study was to describe the morphological characteristics of lymph nodes (LNs) on MRI in ASCC patients with PET-CT-posi

Background Heart failure (HF) commonly arises as a complication to cardiovascular diseases and is closely associated with various comorbidities. The impacts of these comorbidities in patients with HF are diverse. We aimed to analyze the increased risk for cardiovascular-related readmission within 100 days after discharge in patients with HF depending on their different comorbidities. Methods A pop

Background: Outliers can influence regression model parameters and change the direction of the estimated effect, over-estimating or under-estimating the strength of the association between a response variable and an exposure of interest. Identifying visit-level outliers from longitudinal data with continuous time-dependent covariates is important when the distribution of such variable is highly sk

Under medeltiden, men även under århundradena närmast efter, var läkekonsten och vården av sjuka ett brokigt kunskapsfält med flera olika traditioner, medicinska kulturer och praktiker. Sedan medeltiden hade kristenheten dryftat och stridit om vilket ansvar människan har för sin kropp i förhållande till Guds allmakt över liv och död, om smärtans ok visavi lidandet som möjlighet till religiös botgö