Osteoarthritis (OA) is a highly prevalent joint disease, affecting millions of people worldwide and characterized by degradation of articular cartilage, subchondral bone remodeling and low-grade inflammation, leading to pain, stiffness and disability. Cartilage Oligomeric Matrix Protein (COMP) is a major structural component of cartilage and its degradation has been proposed as a marker of OA seve

Context. Stars presently identified in the bulge spheroid are probably very old, and their abundances can be interpreted as due to the fast chemical enrichment of the early Galactic bulge. The abundances of the iron-peak elements are important tracers of nucleosynthesis processes, in particular oxygen burning, silicon burning, the weak s-process, and α-rich freeze-out. Aims. The aim of this work i

Currently facing the problems of security of supply and higher electricity prices in southern Sweden, a medium-large power plant is considered to be built. To prepare for the possible outcome, a study of different cycle configurations was conducted. The study analyzed a 500 MWeldistrict heating mode power plant based on the Avedare power plant in Denmark, a single reheat Rankine cycle with a heat

PURPOSE: Clinical relapse is the major threat for patients with myelodysplastic syndrome (MDS) undergoing hematopoietic stem-cell transplantation (HSCT). Early detection of measurable residual disease (MRD) would enable preemptive treatment and potentially reduced relapse risk.METHODSPatients with MDS planned for HSCT were enrolled in a prospective, observational study evaluating the association b

Photolabile (µ-peroxo)(µ-hydroxo)bis[bis(bipyridyl)-cobalt-based caged oxygen compounds have been synthesized and characterized by optical absorbance spectroscopy, X-ray crystallography. and the quantum yield and redox stability were investigated. Furthermore, conditions were established where redox incompatibilities encountered between caged oxygen compounds and oxygen-dependant cytochrome c oxid

Background and aim: Blue Rubber Bleb Nevus Syndrome (BRBNS) is a rare congenital vascular entity, mainly characterized by cutaneous and gastrointestinal venous malformations. BRBNS remains relatively unexplored and only limited descriptive data is available. The aim of this study was to evaluate the clinical features, diagnostic work-up and therapeutic management in current practice. Methods: A mu

We consider the Boussinesq equation on the line for a broad class of Schwartz initial data for which (i) no solitons are present, (ii) the spectral functions have generic behavior near \pm1, and (iii) the solution exists globally. In a recent work, we identified 10 main sectors describing the asymptotic behavior of the solution, and for each of these sectors we gave an exact expression for the lea

High-intensity neutron beams, such as those available at the European Spallation Source (ESS), provide new opportunities for fundamental discoveries. Here, we discuss a novel Ramsey neutron-beam experiment to search for ultralight axion dark matter through its coupling to neutron spins, which would cause the neutron spins to rotate about the velocity of the neutrons relative to the dark matter hal

We study the flow stability and spatiotemporal spectral dynamics of cellulose nanocrystal (CNC) suspensions in a custom Taylor-Couette flow cell using the intrinsic shear induced birefringence and liquid crystalline properties of CNC suspensions for flow visualizations, for the first time. The analysis is performed at constant ramped speed inputs of the independently rotating cylinders for several

Getting or paying “interest” on loans is probably the most vehemently and frequently debated subject of Islamic economics. There is no doubt that the Holy Quran forbids riba, but the question is: Does the Holy Quran give a “divine” definition of riba or its scope? Unfortunately, the Holy Book of Islam, which is the primary source of reference for Muslims, offers no “divine” definitions. Definition

An unprecedented upsurge in mpox, caused by clade I of the monkeypox virus (MPXV) was noted in Central Africa in 2024. The first mpox case with MPXV clade Ib outside Africa was reported in Sweden in mid-August. The case experienced a mild disease course after travelling to an affected country. No additional cases of this clade have been detected in Sweden. Strengthened public health measures and s

While organic matter (OM) interactions in the water column prevent iron (Fe) precipitation and sedimentation, Fe also acts as a precursor of aggregation and a vector of OM to sediments. This study aims to characterize Fe–OM interactions to understand the role of Fe in promoting aggregation and transport of OM. Samples of Fe and OM were collected from water, settling material, and sediment along a

Over the years, Carbon Capture and Sequestration (CCS) has been recognized as a crucial element in the toolkit of measures to combat climate change. At the European Union (EU) level, CCS plays a vital role in climate policy, particularly in reducing CO2 emissions from hard-to-abate industries. However, no comprehensive legal framework covers all stages of CCS. These stages include carbon capture t

Flooding is one of the natural hazards that pose the most serious threat to human societies in Rwanda, particularly in the Sebeya catchment located in the northwestern part of the country. The main aims of this study are to identify the current flooding issues in the Sebeya catchment in Rwanda and to propose recommendations for improved flood risk management (FRM). The methodology employed encompa

Aims: We aimed to create a predictive model utilizing machine learning (ML) to identify new cases of congestive heart failure (CHF) in individuals with diabetes in primary health care (PHC) through the analysis of diagnostic data. Methods: We used a sex- and age-matched case–control design. Cases of new CHF were identified across all outpatient care settings 2015–2022 (n = 9098). We included indiv

Background: Medication overuse headache is a prevalent secondary headache due to the overuse of analgesics, mainly over-the-counter analgesics. Over-the-counter analgesics have been associated with disrupted male endocrinology, while the effects on female endocrinology remain nearly unknown. The aim was to understand the effect of long-term analgesic exposure in females with medication overuse hea

Apolipoprotein A-I (ApoA-I), the primary component of high-density lipoprotein (HDL) cholesterol primes β-cells to increase insulin secretion, however, the mechanisms involved are not fully defined. Here, we aimed to confirm ApoA-I receptors in β-cells and delineate ApoA-I-receptor pathways in β-cell insulin output. An LRC-TriCEPS experiment was performed using the INS-1E rat β-cell model and ApoA

In the context of a geological repository for nuclear waste, fast and accurate predictions of decay heat are needed for different applications ranging from canister loading optimization to comparing decay heat predictions from state-of-the-art codes with experimental measurements. This work uses a large database of simulated pressurized water reactor (PWR) spent nuclear fuel (SNF) with an extensiv

In this study, we investigate the valorization of 5-(hydroxymethyl)furfural (5-HMF), a versatile and pivotal renewable C6 platform chemical, into a C12 heteroaromatic triol, 5,5′-bis(hydroxymethyl)furoin (DHMF), and a C12 heteroaromatic diol, 5,5′-bis(hydroxymethyl)furil (BHMF). The carboligation of 5-HMF to DHMF is catalyzed by an N-heterocyclic carbene, 1,3,4-triphenyl-4,5-dihydro-1H-1,2,4-triaz