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Background Alcohol use disorder (AUD) is clinically heterogeneous. We examine its potential genetic heterogeneity as a function of sex, age, clinical features and mode of ascertainment. Methods In the Swedish population born 1932-1995 (n = 5 829 952), we examined the genetic risk profiles for AUD, major depression (MD), anxiety disorders, bipolar disorder, drug use disorder (DUD), attention defici

We describe a case of an adolescent male with Niemann-Pick Type C (NP-C), a neurodegenerative lysosomal lipid storage disorder, who presented with recurrent catatonia which required repeated treatment with electroconvulsive therapy (ECT). During the ECT-course, seizure threshold increased substantially, leading to questions about the influence of NP-C on neuronal excitability. In this exemplary EC

PREMIERE: Premiered by Hu Liu during the 2017 China-ASEAN Music Week at the Guangxi University of the Arts on May 28th.NOTE:Imitating the Vivacity of the Human Voice, is a meditation on diversity and the roiling of coexistence. In this piece disparate components from east and west do not suggest a transcendent unification. Rather, rhetorical devices such as “Tiaogong” [跳弓] or “Schleifer” become so

Lingua-Palatal #2, has been totally recomposed in 2020, and is written for four voices that use close amplification to heighten the resonant differences between the oral and nasal cavities. This should be a very strong effect, as if the listener is actually inside the cavity. Therefore, special care must be given to the microphone type and placement. It might even be possible to put microphones in

BACKGROUND: There is no consensus on best content, set-up, category of involved healthcare professionals or duration of rehabilitation-programs for patients with chronic musculoskeletal pain, and outcomes show varying results. Individual care regimes for sub-groups of patients have been proposed.AIM: To describe the type of interventions used in a physiotherapist-led, rehabilitation-program for pa

NanoMAX is the first hard X-ray nanoprobe beamline at the MAX IV laboratory. It utilizes the unique properties of the world's first operational multi-bend achromat storage ring to provide an intense and coherent focused beam for experiments with several methods. In this paper we present the beamline optics design in detail, show the performance figures, and give an overview of the surrounding infr

Novel methods for the inference of radiation intensityfunctions defined over known surfaces are proposed, intendedfor use in surveying applications with mobile spectrometers.Previous approaches, based on the maximum likelihoodexpectation maximization (ML-EM) framework with Poissonlikelihoods, are extended to better handle spatially continuousintensity statistics using ideas from Gaussian filtering

This article addresses the distributed cooperative control design for a class of sampled-data teleoperation systems with multiple slave mobile manipulators grasping an object in the presence of communication bandwidth limitation and time delays. Discrete-time information transmission with time-varying delays is assumed, and the Round-Robin (RR) scheduling protocol is used to regulate the data tran

Epithelial ovarian cancer (OC) is a disease with high mortality due to vague early clinical symptoms. Benign ovarian cysts are common and accurate diagnosis remains a challenge because of the molecular heterogeneity of OC. We set out to investigate whether the disease diversity seen in ovarian cyst fluids and tumor tissue could be detected in plasma. Using existing mass spectrometry (MS)-based pro

The vascular system is vital for all tissues and the interest in its visualization spans many fields. A number of different plant-derived lectins are used for detection of vasculature; however, studies performing direct comparison of the labeling efficacy of different lectins and techniques are lacking. In this study, we compared the labeling efficacy of three lectins: Griffonia simplicifolia isol

Introduction: The use of medications in the general population has increased over time. Information on active metabolite concentrations for common drugs in the general population is limited. Recent advances in metabolomic technologies have made high-throughput profiling of many active metabolites in large epidemiological cohorts increasingly feasible.Aim: 1. Prospective assessment of the proportio

AimOur aim was to describe the outcomes of multisystem inflammatory syndrome in children (MIS-C) associated with COVID-19.MethodsThis national, population-based, longitudinal, multicentre study used Swedish data that were prospectively collected between 1 December 2020 and 31 May 2021. All patients met the World Health Organization criteria for MIS-C. The outcomes 2 and 8 weeks after diagnosis are

Smart cities are increasingly advocated by governments and the private sector as the primary means to deliver urban sustainability. Particularly in Europe and North America, the smart city is envisioned as a place where digital technologies are deployed to ‘solve’ urban sustainability problems. Such visions have been broadly cri- tiqued in the urban studies literature for reflecting techno-utopian

The wisdom of ‘smart’ development increasingly shapes urban sustainability in Europe and beyond. Yet, the ‘smart city’ paradigm has been critiqued for favouring technological solutions and business interests over social inclusion and urban innovation. Despite the rhetoric of ‘citizen-centred approaches’ and ‘user-generated data’, the level of stakeholder engagement and public empowerment is still

Existing post-occupancy research rarely considers the importance of the sociality of the building user community and its building user group dynamics. A social value agenda is proposed to promote user- centred design within the built environment, by looking beyond physical design to consider the dy- namic interactions that exist between people and their built environment within the social context

We reflect on the decision to abandon the mainstreaming of zero-carbon house building in England, in the context of our paper (Walker et al. 2015) that took this long-standing policy commitment as its case study. We consider this denouement as further evidence of how the exigencies of capital accumulation resist moves towards low-carbon transition. We reflect on what it reveals about the relation