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Treatment of tumour cell with 5-aza-2-deoxycytidine (DAC) for immune tumour therapy of Glioma in Fischer-344 rats

Fisher 344 rats with implanted N29 glioma tumours were treated with Pulsed Electric Fields (PEF) in combination with immunization using either IFN-gamma-gene-transfected syngeneic tumour cells or IFN-gamma transfected N29 cells treated with 10 micro-M 5-aza-2-deoxycytidine (DAC). Tumours (N29) were inoculated subcutaneously on both thighs of female F- 344 syngeneic rats. The left tumour was treate

Internal Simulation of an Agent`s Intentions

We present the Associative Self-Organizing Map (A-SOM) and propose that it could be used to predict an agent's intentions by internally simulating the behaviour likely to follow initial movements. The A-SOM is a neural network that develops a representation of its input space without supervision, while simultaneously learning to associate its activity with an arbitrary number of additional (possib

Waves of media democratization: A brief history of contemporary participatory practices in the media sphere

The article aims to provide a more historically grounded approach to the relationship between communication and participation, by distinguishing different waves of media democratization. The article first discusses the concept of participation and some of its complexities, and then sketches a series of intense moments of participation in and through the media in (mainly the second half) the 20th a

Association of STAT4 Polymorphism with Severe Renal Insufficiency in Lupus Nephritis.

Lupus nephritis is a cause of significant morbidity in systemic lupus erythematosus (SLE) and its genetic background has not been completely clarified. The aim of this investigation was to analyze single nucleotide polymorphisms (SNPs) for association with lupus nephritis, its severe form proliferative nephritis and renal outcome, in two Swedish cohorts. Cohort I (n = 567 SLE cases, n = 512 contro

Atrial fibrillation (AF) and co-morbidity in elderly. A population based survey of 85 years old subjects

The occurrence of AF increases sharply with age. The aim of this study was to explore and compare prevalent co-morbidity and self-estimated health-related quality of life (HRQoL) in subjects with AF versus subjects with sinus rhythm or pacemaker in 85 years old subjects. We analyzed data from a population of 336 eighty-five years old subjects participating in the Elderly in Linkoping Screening Ass

The Creator vs. the Creative Man in Romanian Literature (The period between the wars vs. the communist regime)

The myth of creation is a fundamental part of any culture and this is the reason why I consider necessarily and useful to point to the way in which this myth has been artistically expressed in Romanian literature, both in times of successful aesthetic creation and during the regime, which attempted to distort the significance of art. The enrichment of the myth with the idea of the creative man was

Production of pi/K/p from intermediate to high p(T) in pp, p-Pb and Pb-Pb collisions measured by ALICE

In this work the results on the transverse momentum distributions (similar to 0.3 < p(T) < 15 GeV/c) of charged pions, kaons and (anti)protons, measured in pp and Pb-Pb collisions at root S-NN = 2.76 TeV and in p-Pb collisions at root S-NN = 5.02 TeV, presented. The evolution of the spectral shapes and particle ratios with multiplicity is shown and the similarities among the different systems are

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Colorectal cancer is the third most common cancer in the Western hemisphere and the incidence increases with increasing age. Most colorectal cancers are localized with or without lymph node metastases. Up to 20% of patients present with metastatic disease, most commonly to the liver. Surgery is the only curative therapy for localized colorectal cancer and adjuvant chemotherapy is usually recommend

Single nucleotide polymorphisms in the 20q13 amplicon genes in relation to breast cancer risk and clinical outcome

The 20q13 region is frequently amplified/overexpressed in breast tumours. However, the nature of this amplification/overexpression is unknown. Here, we investigated genetic variation in five 20q13 amplicon genes (MYBL2, AURKA, ZNF217, STK4 and PTPN1) and its impact on breast cancer (BC) susceptibility and clinical outcome. As a novel finding, four polymorphisms in STK4 (rs6017452, rs7271519) and A

Endogenous Dynamics of Institutional Change

A parsimonious set of mechanisms explains how and under which conditions behavioral deviations build into cascades that reshape institutional frameworks from the bottom up, even if institutional innovations initially conflict with the legally codified rules of the game. Specifically, we argue that this type of endogenous institutional change emerges from an interplay between three factors: the uti

Hälsopromotion i skolan. Utvärdering av DISA - ett program för att förebygga depressiva symtom hos ungdomar.

Popular Abstract in Swedish Bakgrund Hälsopromotion i skolan förespråkas för att främja välmående och förebygga depressiva symtom hos ungdomar, men insatsernas effektivitet och kostnadseffektivitet behöver utvärderas löpande. Depressiva symtom klassas av WHO som den största sjukdomsbördan hos unga människor och skapar såväl stort lidande för den enskilda och de anhöriga, som höga samhällskostnaderBackground: DISA (Depressive Symptoms In Swedish Adolescents) is a cognitive behavioral intervention aimed at preventing stress and depressive symptoms in adolescents. It is frequently used in Swedish schools for students aged 13-15 years. DISA is commonly offered to females, but at some schools, the intervention is also offered to males. In this study, the application of the intervention for both

Book Reviews

Religion Crossing Boundaries: Transnational Religious and Social Dynamics in Africa and the New African Diaspora. Edited by Afe Adogame and James V. Spickard. Religion and the Social Order Series, 18. Boston, Massachusetts, USA, Brill 2010. Pp. 280. $53.50. African Christian Presence in the West: New Immigrant Congregations and Transnational Networks in North America and Europe. Edited by Frieder

"Kärlek mötte mig i varje stycke" : mission och materialitet i det humanitära arbetet bland armeniska flyktingar i Thessaloniki, 1923-1947

In this article I discuss how material things can function as a key to a wider understanding of the mission enterprise. From the example of the Swedish missionary Alma Johansson, who worked among Armenian refugees in Thessaloniki, 1923–1947, I analyze the role of needlework in the humanitarian work and show how exchanges of needlework over the borders created cosmopolitan bonds of solidarity betwe

Performance analysis for the CALIFA Barrel calorimeter of the (RB)-B-3 experiment

The CALIFA calorimeter is an advanced detector for gamma rays and light charged particles, accordingly optimized for the demanding requirements of the physics programme proposed for the (RB)-B-3 facility at FAIR. The multipurpose character of CALIFA is required to fulfil challenging demands in energy resolution (5-6% at 1 MeV for gamma rays) and efficiency. Charged particles, e.g. protons of energ