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AbstractThis research aims to investigate and compare how computers work on five different workstation setups of multiple or large screens and viewing distances (27-inch and 49-inch at 70 or 90 cm viewing distance) affect muscular load in neck/shoulders, working postures, and perceived exertions of non-presbyopic participants. The electrical activity in the trapezius shoulder and trapezius neck muThis research aims to investigate and compare how computers work on five different workstation setups of multiple or large screens and viewing distances (27-inch and 49-inch at 70 or 90 cm viewing distance) affect muscular load in neck/shoulders, working postures, and perceived exertions of non-presbyopic participants. The electrical activity in the trapezius shoulder and trapezius neck muscles, a

AbstractEyestrain is a common issue when performing visually demanding work, often accompanied by neck and shoulder strain, as well as visual problems such as dim vision. The aim of this paper is to investigate the association between eyestrain and musculoskeletal strain, as well as the association between eyestrain and visual symptoms. Two regression analyses were conducted on subjective ratings Eyestrain is a common issue when performing visually demanding work, often accompanied by neck and shoulder strain, as well as visual problems such as dim vision. The aim of this paper is to investigate the association between eyestrain and musculoskeletal strain, as well as the association between eyestrain and visual symptoms. Two regression analyses were conducted on subjective ratings of eyest

Objective: An elevated sodium-to-potassium (Na/K) ratio in urine increases the risk of hypertension. Tooth loss in older adults can lead to a diminished nutritional state, including alterations in the Na/K ratio. However, the relationship between denture use and changes in the Na/K ratio among individuals with tooth loss has not been sufficiently explored. This study examined whether denture use m

Background & Aims The risk of hepatocellular carcinoma (HCC) in primary sclerosing cholangitis (PSC) is unclear. Studies indicate a low risk for HCC questioning the rationale for current HCC surveillance guidelines. This study explores the risk of HCC in a longitudinal multicenter cohort with over 3.000 PSC-subjects. Approach & results Subjects with well characterized PSC (n=3.071) were fo

Subjective cognitive decline (SCD) is proposed as an indicator of transitional disease stage 2 in the Alzheimer’s disease (AD) continuum. However, molecular and particularly longitudinal fluid biomarker data for this stage are still limited. This study aimed to determine whether blood-based biomarkers in amyloid-positive individuals with SCD (A + SCD) support the notion of stage 2 as a distinct st

Objective: Quality measures in healthcare are crucial for improving outcomes and ensuring patient safety. This study investigated the evolution, implementation, and impact of Primary Care Quality (PCQ). The PCQ aims to facilitate nationwide quality benchmarking, serving as a tool for quality improvement (QI) and research. Design/Settings: A descriptive design outlining the development and operatio

Introduction: Chemoradiotherapy is standard treatment for limited-stage SCLC. However, most patients relapse and there is a need for better treatment. We investigated whether twice-daily thoracic radiotherapy (TRT) of 60 Gy/40 fractions improves survival compared with the established schedule of 45 Gy/30 fractions. Here, we report final survival data and long-term toxicity. Methods: Randomized, op

Objectives: Coagulation test results may be affected by hemolysis, icterus and/or lipemia (HIL). Detailed guidelines for HIL-management are missing, both for manual and automatic HIL-checks. The aim of this survey was to provide an overview of the practical procedures for the detection and handling of HIL-samples used by laboratories in Europe in the context of coagulation testing. Methods: A Surv

Humans and animals communicate with rhythmic behaviours that vary greatly in terms of temporal parameters and patterns. In this chapter we discuss the neuromuscular architecture underlying rhythmic behaviours and address factors that constrain their rhythmic properties. In Part I of the chapter we provide background regarding the building blocks of rhythmic communication from the muscles to the br

Background and aims: The relationship between uncommon phenotypes, such as metabolically healthy obesity and normal weight with metabolic syndrome (MetS), and cardiovascular disease (CVD) risk, remains unclear. We investigated how different combinations of body mass index (BMI) and MetS are associated with overall and specific CVDs and how the number of MetS components influences CVD risk in indiv

Group Exhibition. Carlier-Gebauer. September - October 2025.Fluid Systems explores fluidity as a site of metamorphosis: a continuous, ideologic process in which gender, identity, and social constructs dissolve into transient states of becoming. Engaging with the transcendence of fixed categories, it foregrounds phenomena that resist comprehension, gesturing toward the unknown as both subject and m

Purpose: Children and youth with disabilities are at increased risk of abuse a major societal and public health problem in Cameroon. The aim was to explore the causes of abuse among children and youth with disabilities in homes and institutions in the Northwest Region of Cameroon. Methods: A qualitative study was conducted, including 50 in-depth interviews with children and youth with disabilities

Understanding the interplay between human brain structure and function is crucial to discern neural dynamics. This study explores the relation between brain structure and macroscale functional activity using subject-specific structural connectome eigenmodes, complementing prior work that focused on group-level models and geometry. Leveraging data from the Human Connectome Project, we assess accura

Mesosiderites are rare, differentiated meteorites, so-called stony-iron meteorites—they are impact breccias composed of an unusual mix of crustal basalt and pyroxenite, core-derived metal, but no mantle materials. This odd mixture makes their origin enigmatic and has inspired many different formation theories over the last several decades. Some of the outstanding questions have regarded the origin

In this work, we revisit unweighted event generation for multi-parton tree-level processes in massless QCD. We introduce a two-step approach, in which initially unweighted events are generated at leading-colour (LC) accuracy, followed by a reweighting of these events to full-colour (FC) accuracy and applying an additional unweighting cycle. This method leverages the simple structure of LC integran

BACKGROUND: This study aimed to evaluate the prevalence of pathogenic/likely pathogenic cardiomyopathy variant carriers in a multiancestry US population and examine the risk of adverse clinical outcomes. METHODS: This retrospective cohort study included multiancestry US adults aged ≥18 years with sequencing data from the All of Us Research Program. Pathogenic/likely pathogenic variants in cardiomy

Insulin secretion from vesicles within pancreatic beta cells occurs through the rapid (≤10 ms) process of exocytosis. A crucial final step in this process is the formation of a fusion pore, which connects the insulin vesicle interior to the extracellular space and insulin secretion rate. We employed real-time single-cell amperometry (SCA) with microsensors to quantitatively and dynamically monitor