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Characterization of SLC40A1 in Acute Myeloid Leukemia by CRISPRi Gene Editing

Acute myeloid leukemia (AML) is characterized by an accumulation of immature blast cells, which outgrow the bone marrow and suppress normal blood formation. The condition is associated with poor survival, mainly caused by relapsed and refractory disease. Hence, new therapeutics are needed. Recently, SLC40A1 was identified as potentially important for AML cells in a pooled CRISPR interference scree

Forming wide-orbit planets via pebble accretion

The possibility that detected substructures in protoplanetary disks, such as gaps, rings and cavities, are created by distant protoplanets has prompted an inquiry into the mechanism responsible for their formation. These wide-orbit young bodies are likely to form relatively rapidly in the outer regions of circumstellar disks. Pebble accretion is considered a promising candidate to explain their fo

Modelling the full-scale N2O emissions from wastewater treatment plants for identifying mitigation strategies

Nitrous oxide (N2O) emissions, which primarily originate from the biological nitrogen removal process, dominate the release of greenhouse gases (GHGs) in wastewater treatment plants (WWTPs). N2O production occurs through dynamic microbial pathways that have a significant impact on the environment compared with other GHG emissions. Reducing these substantial emissions aligns with the objectives of

Impact of powder size on Spark Plasma Sintering of Indium Sulfide

As society’s electricity demands increase, technical solutions and advancements are essential to meet energy needs. Solar energy is a promising source, and solar cells enable the conversion of sunlight into electricity. This study is in collaboration with Midsummer AB, a Swedish company that specializes in sustainable solar cells. The company employs a sputtering process for manufacturing these ce

Test av reliabilitet och validitet för den svenska versionen av Mini-BESTest för personer med stroke i subakut fas och traumatisk hjärnskada i kronisk fas

Bakgrund Människor som drabbats av stroke eller traumatiska hjärnskador (TBI) får ofta balanssvårigheter som kan påverka aktivitet och delaktighet negativt. Mini-Balance Evaluation Systems Test (Mini-BESTest) är ett mätinstrument som kan användas för att utvärdera balansförmågan, men dess reliabilitet och validitet är inte helt klarlagt efter stroke och TBI. Syfte Syftet med studien var att under

Business Model Innovation to Commercialize Plant-Based Portion Pack Beverages

Due to rising concerns about climate change, launching plant-based portion pack beverages is one opportunity to address this issue. Embracing this opportunity of value creation, requires a business model innovation. The purpose of this study is to improve the understanding of how companies in the food industry develop a new customer value proposition with business model innovation, and how this ca

Legacy effects of temperature alterations on microbial resistance and resilience to drying and rewetting

With warming in soils due to climate change, a series of secondary factors arise, which have multifaceted effects on soil microbial communities. Of these, alterations to soil moisture are among the most crucial to understanding how microbial functions will change in the face of climate change. As living organisms, microbes must adapt to their environment, and their adaptations are reflected in the

Hållbarhetsmått, hållbarhetsanseende och finansiell prestation- En jämförande studie av hur hållbarhetsmått och konsument-hållbarhetsanseende påverkar företags finansiella prestation

Examensarbetets titel: Hållbarhetsmått, hållbarhetsanseende och finansiell prestation En jämförande studie av hur hållbarhetsmått och konsument-hållbarhetsanseende påverkar företags finansiella prestation Seminariedatum: 1 juni 2023 Ämne/kurs: FEKH29, Examensarbete i marknadsföring på kandidatnivå, 15 högskolepoäng Författare: Ella Martell, Isabella Träskman och Jessica Wigren Handledare: Burak TuTitle: Sustainability measures, sustainability reputation and financial performance A comparative study of how sustainability measures and consumer sustainability reputation affect companies' financial performance Seminar date: 1 June 2023 Course: FEKH29, Degree Project, Undergraduate level, Business Administration 15 University Credits Points (UPC) or ECTS‐cr) Authors: Ella Martell, Isabella

Japanese wood craftsmanship and digital technology

Wood is increasingly being recognized as one of the most promising building materials on the market as a result of environmental challenges. Aside from the fact that wood is a sustainable material, it has the benefit of being high-quality, strong, flexible, and speedy to construct, which makes it a much more attractive material compared to its less sustainable counterpart. The latest computational

Detection of insurance fraud using NLP and ML

Försäkringsbolag behöver identifiera och hantera en stor mängd potentiellt bedrägliga försäkringsanspråk från deras kunder. Därför har försäkringsbolag en rad system för att försöka identifiera vilka anspråk som är bedrägliga och vilka som inte är det. Med den senaste utvecklingen inom maskininlärning och särskilt inom området för språkbehandling (NLP) kan dessa tekniker eventuellt användas för atMachine-Learning can sometimes see things we as humans can not. In this thesis we evaluated three different Natural Language Procces-techniques: BERT, word2vec and linguistic analysis (UDPipe), on their performance in detecting insurance fraud based on transcribed audio from phone calls (referred to as audio data) and written text (referred to as text-form data), related to insurance claims. We al

Practical Trials of Fiber Optical Gyroscope Based Inertial Navigation System

There exists a need for inertial navigation systems within a multitude of applications, such as drones, unmanned vehicles, and guidance systems. Saab produces gyroscopes for stabilization purposes, but the gyroscopes could also be used as part of an inertial navigation system. This thesis investigate the viability of using the hardware and software that Saab already uses, with the addition of acce

Att balansera mellan stringens och relevans - Kuratorers perspektiv på standardiserade vårdprocesser i Barn- och Ungdomspsykiatrin

The aim of this study was to examine the experiences and thoughts of health care social workers regarding working according to standardized care processes in child and adolescent mental health care (Barn- och Ungdomspsykiatrin). The research questions concerned what challenges and opportunities standardized care processes bring and how it affect the health care social workers professional role and

From Manual to Robotic -Assessing the Potential Benefits of Automation in Railway Inspections and Maintenance

Järnvägsindustrin spelar en avgörande roll på den globala marknaden för godstransporter och passagerarmobilitet, och ger ett effektivt och lågemitterande transportmedel. För att konkurrera med andra transportmedel måste järnvägen dock förbättra sin tillförlitlighet. Frekventa inspektions- och underhållsarbeten är avgörande för att säkerställa säkerheten och effektiviteten i järnvägsverksamheten. DThe railway industry plays a crucial role in the global freight transport and passenger mobility market, providing an efficient and low-emitting mode of transportation. However, to compete with other modes of transportation, the railway must improve its reliability. Frequent inspection and maintenance work are essential for ensuring the reliability, safety, and efficiency of railway operations. Th

From Vision to Action: Factors and Strategic Tools in Implementing Corporate Sustainability Strategies A Case Study of a Consulting Firm in the Nordics: Company X

Today's company strategy should include sustainability as a key component. There, however, exists uncertainty regarding the implementation of corporate sustainability strategies. Previous research has explored the role of consulting firms in shaping sustainability practices, but there has been a lack of investigation into how these firms implement their sustainability strategies. This study ai

Säljaren - den fysiska butikens viktigaste tillgång

Tidigare forskning belyser hur viktiga säljarna har blivit för den fysiska butiken när retailbranschen står i en omställning. Samtidigt lyfts befattningsosäkerhet som något som har inverkan på säljarnas motivation inför arbetet och i sin tur även deras prestationer. Ett forskningsgap identifierades då nuvarande forskning av befattningsosäkerhet i stor utsträckning utgjordes av kvantitativa enkäter

Vem betalar för prishöjningarna? - Inflation, ojämlikhet och makt

This paper examines the relationship between inflation, inequality, and political power. The author argues that the redistributive effect of the inflation tax is a product of four channels: real wages, the balance sheet, debt and fiscal policy. The role of elite bias in politics, and its effect on inflation combating measures is also investigated. One interesting finding is that inflation had a re

The Carbon Impact of Component Production in China: Investigating the Impact of Carbon Border Adjustment Policies for a Global Manufacturing Company

Title: The Carbon Impact of Component Production in China: Investigating the Impact of Carbon Border Adjustment Policies for a Global Manufacturing Company Authors: Fabian Bergman & Spiros Pavlidis Supervisor: Eva Berg, Lecturer at Engineering Logistics, Faculty of Engineering (LTH) at Lund University Examiner: Louise Bildsten, Associate Lecturer at Engineering Logistics, Faculty of Enginee

Förankringskapacitet i cementsnåla småhusgrunder

Byggindustrin står inför nya utmaningar i form av skärpta krav när det gäller dess klimatpåverkan. En betydande faktor för byggindustrins klimatpåverkan är den cement som används i betong, eftersom det i samband med tillverkning av cement frigörs stora mängder koldioxid. Platta på mark är en vanlig typ av grundläggning i byggnader i mindre skala, såsom småhus. En typisk småhusplatta av betong ha