The charge and proton dynamics in hydrogen-bonded networks are investigated using ammonia as a model system. The fragmentation dynamics of medium-sized clusters (1-2 nm) upon single photon multi-ionization is studied, by analyzing the momenta of small ionic fragments. The observed fragmentation pattern of the doubly- and triply-charged clusters reveals a spatial anisotropy of emission between frag

C-type lectin domain family 3 member A (CLEC3A) is a poorly characterized protein belonging to the superfamily of C-type lectins. Its closest homologue tetranectin binds to the kringle 4 domain of plasminogen and enhances its association with tissue plasminogen activator (tPA) thereby enhancing plasmin production, but whether CLEC3A contributes to plasminogen activation is unknown. Here, we recomb

Over the last decade, sustainability science has been at the leading edge ofwidespread efforts from the social and natural sciences to produce use-inspired research.Yet, how knowledge generated by sustainability science and allied fields will contribute totransitions toward sustainability remains a critical theoretical and empirical question forbasic and applied research. This article explores the

Background: Difficulty in following and understanding conversation in different daily life situations is a common complaint among persons with hearing loss. To the best of our knowledge, there is currently no published validated Norwegian questionnaire available that allows for a self-assessment of unaided communication ability in a population with hearing loss. Purpose: The aims of the present st

Host cell surface carbohydrate receptors of bacterial adhesins are attractive targets in anti-adhesion therapy. The affinity of carbohydrate ligands with adhesins is usually found in the low μm range, which poses a problem for the design of effective inhibitors useful in therapy. In an attempt to increase the inhibitory power of carbohydrate ligands, we have combined the approach of chemical modif

Metastasis is the leading cause of death in patients with advanced melanoma, yet the somatic alterations that aid tumour cell dissemination and colonisation are poorly understood. Here, we deploy comparative genomics to identify and validate clinically relevant drivers of melanoma metastasis. To do this, we identified a set of 976 genes whose expression level was associated with a poor outcome in

Den yttersta barriären mellan luften och blodomloppet i våra lungor består av en lipid-protein film. Denna lipid-protein blandning kallas för lungsurfaktant. Filmen bestående av lungsurfaktant stabiliserar alveolerna i våra lungor och gör att vi kan andas utan motstånd. Brist av lungsurfaktant kan orsaka svåra sjukdomar, till exempel hos förtidigt födda barn som ännu inte hunnit bilda tillräckligtThis thesis explores lipid self-assembly and aims to give a broad picture of self-assembly structures in simple and complex lipid-protein systems. The systems studied are lung surfactant, stratum corneum and simple model membranes. The lung surfactant mixture lines the alveolus in our lungs and stabilises the air- tissue interface. The lung surfactant lipid phase behaviour was here investigated wi

Background Breathlessness is associated with major adverse health outcomes and is twice as common in women as men in the general population. We evaluated whether this is related to their lower absolute lung volumes. Methods Cross-sectional analysis of the population-based Swedish CardioPulmonarybioImage Study (SCAPIS) Pilot, including static spirometry and diffusing capacity (n = 1,013; 49% women)

The evolution towards centralized radio access network (C-RAN) for 5G is driven by the need for improved network performance and reduced total-cost-of-ownership (TCO). In CRAN, physically separated remote radio units (RRUs) and baseband units (BBUs) are connected via fronthaul (FH) links, which are capacity constrained. When base-station antennas are upgraded to support massive MIMO techniques, an

Heme oxygenase is an enzyme that degrades heme, thereby recycling iron in most organisms, including humans. Pervious density functional theory (DFT) calculations have suggested that iron(III) hydroxyheme, an intermediate generated in the first step of heme degradation by heme oxygenase, is converted to iron(III) superoxo oxophlorin in the presence of dioxygen. In this article, we have studied the

In the context of a species sampling problem, we discuss a nonparametric maximum likelihood estimator for the underlying probability mass function. The estimator is known in the computer science literature as the high profile estimator. We prove strong consistency and derive the rates of convergence, for an extended model version of the estimator. We also study a sieved estimator for which similar

Dynamic Charging, meaning supplying electric energy to electric vehicles while moving and also referred to as Electric Road Systems (ERS), can be implemented in a number of different ways. In Sweden, no less than four different technologies are being developed and/or demonstrated. This is, in an international comparison, unique. This paper represents an effort to describe these different technolog

Electric Road Systems (ERS) are analysed here as a feasible solution for the electrification of heavy traffic, where the predominant approach for passenger cars based only on batteries and a network of fast-charging stations combined with slower overnight charging becomes unrealistic due to the large amount of batteries required. Nonetheless, this study shows that in most cases, building such ERS

Nowadays Cloud Computing and Cloud Sourcing is on the agenda in many organizations. Many Chief Information Officers (CIOs) that urge for alternatives to traditional outsourcing are interested in how they can take advantage from Cloud Computing, by sourcing Information Technology (IT) from the cloud. This paper provides an overview of the research direction of Cloud Sourcing in the IS field. A lite

Maggots of the blowfly Lucilia sericata are used for the treatment of chronic wounds. As haemostatic processes play an important role in wound healing, this study focused on the effects of maggot secretions on coagulation and fibrinolysis. The results showed that maggot secretions enhance plasminogen activator-induced formation of plasmin and fibrinolysis in a dose- and time-dependent manner. By c

Objectives: Maggots of the blowfly Lucilia sericata are used for the treatment of chronic wounds. Previously we reported that maggot excretions/secretions (ES) break down Staphylococcus aureus biofilms but do not kill the bacteria. As many antibiotics are not effective against biofilms we assessed the effect of combinations of ES and antibiotics on S. aureus biofilms and on the survival of the bac

Background: Maggots of the blowfly Lucilia sericata are used for the treatment of chronic wounds. Earlier we reported maggot secretions to inhibit pro-inflammatory responses of human monocytes. The aim of this study was to investigate the effect of maggot secretions on the differentiation of monocytes into pro-inflammatory (MØ-1) and anti-inflammatory/pro-angiogenic macrophages (MØ-2) as these cel

Recent developments in drilling technology have resulted in about five to ten times faster penetration rates compared to penetration rates of conventional diamond drilling. The increased penetration rates open up for affordable drilling of deep boreholes in regions with cold crust, such as in Scandinavia, allowing for geothermal energy generation in enhanced geothermal systems. We present two infr