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Thyroid function has been suggested to be associated with breast cancer risk, but not much is known about thyroid hormones as a potential prognostic factor for breast cancer. This study investigated the relation between thyroid hormones in breast cancer patients and mortality. A total of 2000 breast cancer patients from the Swedish SCAN-B cohort were followed for 9 years. Blood samples were collec
There is currently widespread concern that rapid technological change will funda-mentally change the nature of work. In this paper we show that, despite 140 years oftechnological change, more than 70 percent of employment today is located in occu-pations whose core economic functions already existed in the late nineteenth century.Full-count Swedish census and administrative data from 1880 to 2019,
Öland is the third-largest island in the Baltic Sea and one of Sweden’s most popular tourist destinations. The island has only 30 000 permanent residents but hosts around 300 000 seasonal residents and tourists each summer. This creates a strong pressure on local water resources, as private well owners, municipal supplies, and agriculture must compete for limited freshwater. The island is among th
The first generation of medical artificial intelligence (AI) was judged on whether algorithms could match clinicians. The next generation should be judged on whether carefully designed human–AI systems can improve patient outcomes.
Childhood stunting remains a major public health concern in low- and middle-income countries, with persistent sub-national disparities. This study examined spatially varying associations between Height-for-Age z-scores (HAZ) and selected child, maternal, and household factors, and compared Geographically Weighted Regression (GWR), Multi-scale GWR (MGWR) and Geographically Neural Network Weighted R
Rb1 plays an important role in cell cycle progression and therefore may be involved in malignant transformation of colonic cells. The aim of our research was to define the potential role of Rb1 as a prognostic biomarker in tumorigenesis of sporadic colorectal cancer, and to examine the role of miR-106a in Rb1 regulation as it functionally binds to 3'UTR of transcribed mRNA. We examined LOH and pro
Complex diseases, such as advanced cancer, can rarely be treated with a single drug. Combinations of treatments are advised for the majority of types. Noncoding RNAs (ncRNAs), with their simultaneous activities and diversity of targets, often reaching several steps of a pathway, could be the right option to develop new treatment modalities. Because of their multifactorial effects, ncRNA-based ther
Objective To investigate the function of a novel primate-specific long non-coding RNA (lncRNA), named FLANC, based on its genomic location (co-localised with a pyknon motif), and to characterise its potential as a biomarker and therapeutic target. Design FLANC expression was analysed in 349 tumours from four cohorts and correlated to clinical data. In a series of multiple in vitro and in vivo mode
BACKGROUND: Emerging evidence suggests that tumour morphological heterogeneity may influence mutational profiles relevant to therapy response. In this pilot study, we aimed to assess whether mutations identified within specific morphological patterns or at the invasion front correlate with shorter time to progression after anti-EGFR therapy, as compared to whole-tissue analysis.METHODS: We investi
Objective of this study was to assess platelet response to clopidogrel and its association with certain single nucleotide polymorphisms (SNPs) of the P2RY12 gene. Several studies have shown that patients with poor in vitro response to clopidogrel have worse outcomes after coronary interventions. Pharmacological response to clopidogrel is mediated by the P2Y12 platelet receptor, therefore, SNPs of
Altered folate levels may play an important role in colon carcinogenesis. The aim of this study was to investigate the association of polymorphisms in key folate-metabolizing genes with susceptibility to sporadic colon cancer. Six common polymorphisms (two in MTHFR and one each in MTR, MTRR, RFC1, and DHFR genes) were genotyped in 300 healthy subjects and 300 colon cancer patients from Croatia. Ob
Cerebral palsy (CP) is a nonprogressive motor disorder caused by white matter damage in the developing brain. Recent epidemiological and clinical data suggest intrauterine infection/inflammation as the most common cause of preterm delivery and neonatal complications, including CP. Cyclooxygenases are key enzymes in the conversion of arachidonic acid to prostaglandins. The COX family consists of tw
Colorectal carcinoma (CRC) results from the accumulation of genetic mutations and alterations in signaling pathways. KRAS is mutated in 40% of CRC cases and is involved in increased tumor cells proliferation and survival. Although KRAS mutations are a dominant event in CRC tumorigenesis, increased wild-type KRAS expression has a similar effect on accelerated tumor growth. In this study, we investi
Hormone-producing cells in the pancreas and intestine regulate whole-body metabolism and are dysregulated in obesity and diabetes. A deeper understanding of endocrine lineage formation (endocrinogenesis) in these organs is essential to elucidate the healthy state and disease trajectories. Here, we performed cross-species (mouse and human) and cross-system (in vivo and in vitro) comparisons of panc
Islets of Langerhans are highly structured mini-organs containing hormone-producing cells of the pancreas that regulate glucose metabolism. Studies of endocrine cell differentiation and clustering into immature proto-islets, as well as remodeling into mature islets, are beginning to clarify the critical timepoints and mechanisms governing islet formation across species. In this review, we compare
