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Cadmium-induced effects on bone in a population-based study of women

High cadmium exposure is known to cause bone damage, but the association between low-level cadmium exposure and osteoporosis remains to be clarified. Using a population-based women's health survey in southern Sweden [Women's Health in the Lund Area (WHILA)] with no known historical cadmium contamination, we investigated cadmium-related effects on bone in 820 women (53-64 years of age). We measured

Aspects on coronary heart disease prevention in clinical practice

Prevention of first time disease or recurrence of coronary heart disease (CHD) is a major task for the health service. Guidelines regarding CHD prevention have been issued but studies have shown that treatment goals are inadequately met in clinical practice and there is urgent need for improved methods of implementation of guidelines. There is also a need for better risk stratification tools in or

Not avoiding the question of complexity

This paper gives an account of progress made in a study commenced during 2004, and previously reported. The theme is contextual analysis in requirements shaping practice. The context is organizational development within a relatively new University department. The Strategic Systemic Thinking Framework is used as the basis for inquiry. The paper outlines the process followed in carrying out the stud

Evolution of hepatitis C virus variants following blood transfusion from one infected donor to several recipients: a long-term follow-up

Variants of hepatitis C virus (HCV) from a single infected blood donor and 13 viraemic recipients who were traced were examined by sequencing and cloning to determine the extent of virus diversity in hypervariable region 1. Serum-derived viral isolates were studied from the donor when his HCV infection was discovered in 1993, in his recipients that year (0·3–5 years post-transfusion) and 5 years l

Calculation of Clothing Insulation by Serial and Parallel Methods: Effects on Clothing Choice by IREQ and Thermal Responses in the Cold

Cold protective clothing was studied in 2 European Union projects. The objectives were (a) to examine different insulation calculation methods as measured on a manikin (serial or parallel), for the prediction of cold stress (IREQ); (b) to consider the effects of cold protective clothing on metabolic rate; (c) to evaluate the movement and wind correction of clothing insulation values. Tests were ca

Redox potentials of the blue copper sites of bilirubin oxidases

The redox potentials of the multicopper redox enzyme bilirubin oxidase (BOD) from two organisms were determined by mediated and direct spectroelectrochemistry. The potential of the T1 site of BOD from the fungus Myrothecium verrucaria was close to 670 mV, whereas that from Trachyderma tsunodae was > 650 mV vs. NHE. For the first time, direct electron transfer was observed between gold electrodes a

The polyamines spermidine and spermine retard the platination rate of single-stranded DNA oligomers and plasmid

The presence of polyamines in living cells is crucial for survival. Due to their high net charge at physiological pH, polyamines effectively charge neutralize the phosphodiester backbone of DNA in an interaction that also may protect the DNA from external damage. We here present a study illustrating the influence of spermidine and spermine on the platination reactions of the model oligonucleotides

Synthesis, characterisation and catalytic investigation of a new type of PC(sp(3))P pincer Pd(II) complex

The diphosphine cis-1,3-bis[(di-tert-butylphosphino)methyl]cyclohexane (2) has been synthesised and its complexation in palladium chemistry has been investigated. Ligand 2 is capable of tricoordination, for instance as demonstrated by an X-ray crystal structure determination of the complex [Pd(2)I], and it is a rare example of a PC(sp(3))P pincer ligand. A catalytic study of the Heck reaction reve

A state that failed? On the Union of Kalmar, especially its dissolution

This paper gives an overview of the history and historiography of the union between Denmark, Norway, and Sweden in the late middle ages, the Union of Kalmar, trying to overcome the national bias of previous research. When seen in a state formation perspective, the union must be regarded as a serious candidate for statehood. Focusing on its last decades, it is shown that it was an important mental

Object characterization with refractometric digital Fourier holography

We demonstrate a digital holographic method in which two different substances in a blend are discerned. The method requires only one set of exposures and one reconstruction in the plane of focus. The phase is unwrapped by Flynn's discontinuity algorithm to produce an image of the variation of the optical distance of the illuminating wave. Objects with indices of refraction that are higher and lowe

Use of cellular or cordless telephones and the risk for non-Hodgkin's lymphoma

Objectives: To evaluate the use of cellular and cordless telephones as the risk factor For non-Hodgkin's lymphoma (NHL). Methods: Male and female subjects aged 18-74 years living in Sweden were Included during a period from I December 1999 to 30 April 2002. Controls were selected from the national population registry. Exposure to different agents was assessed by questionnalre. Results: In total, 9

Are gadolinium contrast media really less nephrotoxic than iodine agents in radiographic examinations? A comparison in relation to their ability to attenuate x-rays in a pig model

Purpose: To confront the statement that gadolinium contrast media (Gd-CM) are less nephrotoxic than iodine contrast media (I-CM) when used in x-ray angiographic and computed tomographic (CT) examinations. Methods: I) For CT measurements (mean density in Hounsfield numbers) 20-mL syringes filled with I- and Gd-CM at 0.01, 0.02, 0.05 and 0.1 mmol attenuating atoms/mL were scanned in air and in a 30