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Popular Abstract in Swedish Neuroblastom är den vanligaste solida tumören, utanför hjärnan, hos små barn och finns nästan inte alls hos vuxna. Varje år insjuknar mellan femton och tjugo barn i Sverige, de flesta före två års ålder. Överlevnaden har ökat de senaste tjugo åren men är fortfarande på låga nivåer för de mer aggressiva formerna. Neuroblastom uppstår i det sympatiska nervsystemet. DärförIn this thesis, the main focus has been on the childhood cancer neuroblastoma, one of the most common and lethal childhood tumours. Neuroblastoma has througout the years continued to be a clinical and biological enigma. Our first focus was on one of the most important biological risk factors in neuroblastoma -- amplification of the oncogene MYCN in the tumour cells. Because amplified MYCN typical

For the first time the direct electron transfer of an enzyme - cellobiose dehydrogenase, CDH - has been coupled with the hexokinase catalyzed competition for glucose in a sensor for ATP. To enhance the signal output for ATP, pyruvate kinase was coimmobilized to recycle ADP by the phosphoenolpyruvate driven reaction. The new sensor overcomes the limit of 1:1 stoichiometry of the sequential or compe

During the last decade, several screening programs for pharmaceuticals at Swedish wastewater treatment plants (WWTPs) have been conducted by research institutes, county councils, and wastewater treatment companies. In this study, influent and effluent concentrations compiled from these screening programs were used to assess the occurrence and reduction of non-antibiotic pharmaceuticals for human u

Popular Abstract in Swedish Alzheimers sjukdom är den vanligaste orsaken till uppkomsten av demens. Detta tillstånd innebär att delar av hjärnan skrumpnar på ett karakteristiskt vis, när nervceller går under. Den drabbade brukar först märka svårigheter med korttidsminnet, för att senare drabbas av språksvårigheter, räknesvårigheter, svårigheter med rumslig uppfattning och svårigheter att veta hur Alzheimer’s disease (AD), the most common cause of dementia, is a growing concern. As the life expectancy increases across the globe, the number of affected people is estimated to reach 100 million by 2050. Efforts to develop effective treatments for humans have mostly been based on the assumption that a faulty homeostasis of beta amyloid (Aβ) is the triggering or the driving factor behind this co

The properties of two-component fermionic quantum systems in two dimensions, such as they nowadays may be realized with cold atoms in traps, are studied within the pairing model adapted from nuclear physics. We compare the results with those of a full numerical diagonalization of the many-body Hamiltonian. The chemical potential differences, excitation energies and angular momentum spectra show th

The elliptic, v(2), triangular, v(3), and quadrangular, v(4), azimuthal anisotropic flow coefficients are measured for unidentified charged particles, pions, and (anti-)protons in Pb-Pb collisions at root S-NN = 2.76 TeV with the ALICE detector at the Large Hadron Collider. Results obtained with the event plane and four-particle cumulant methods are reported for the pseudo-rapidity range vertical

The average charge states of Pb-188 and No-252,No-254 ions in dilute helium gas were measured at the gas-filled recoil separator TASCA. Hydrogen gas was also used as a filling gas for measurements of the average charge state of No-254. Helium and hydrogen gases at pressures from 0.2 mbar to 2.0 mbar were used. A strong dependence of the average charge state on the pressure of the filling gases was

Difference between sexes in parasitism is a common phenomenon among birds, which may be related to differences between males and females in their investment into immune functions or as a consequence of differential exposure to parasites. Because life-history strategies change sex specifically during the annual cycle, immunological responses of the host aiming to reduce the impact of parasites may

The behaviour of building occupants before the purposive movement towards an exit, known as the pre-evacuation behaviour, can have a strong impact on the total time required to leave a building in case of fire emergency as well as on the number of casualties and deaths. The pre-evacuation time can be simulated within computational models using different approaches. This work introduces a new model

Sverige har en vision om ”netto-noll” utsläpp av växthusgaser till 2050 och är på god väg att nå utsatta delmål för utsläppsreduktioner till 2020. Klimatfrågan är dock långsiktig och det under klimatkonventionen antagna 2-gradersmålet innebär utsläppsåtaganden som sträcker sig till år 2050 och bortom. En långsiktigt effektiv klimatpolitik ska därför utvärderas både efter vilka långsiktiga utveck

I denna uppsats behandlas satsadverbialen inte, nog och visst. De undersöks, var för sig, i två positioner i satsen, nämligen fundamentet och den typiska satsadverbials¬positionen (A1). Syftet är att beskriva adverbialens möjliga betydelser i respektive position. Utifrån hur de, i olika talsituationer och kontexter, inverkar på talarens inställning till satsens proposition i fundamentet och i A1,

We show theoretically that the poor can benefit from price changes induced by higher income inequality. As the number of poor increases, the market for products aimed toward the poor grows, and such products become more profitable. As a result, there are circumstances where an increase in income inequality associates with higher purchasing power of the poor. Using cross-country data on the price o

We have investigated the magneto-resistivity (MR) of FeSe1-xTex superconducting films on MgO substrate. The MR of pure FeSe and slightly Te-substituted films demonstrates regular Lorentz-type magnetic field dependence, MR similar to B-2. In highly Te-substituted samples, however, negative MR contribution due to the weak-localization effect gradually dominates at low temperature, which is consisten

To investigate the role of factors that modulate the association between alcohol and mortality, and to provide estimates of absolute risk of death.

We investigate a new method to place patients into risk groups in censored survival data. Properties such as median survival time, and end survival rate, are implicitly improved by optimizing the area under the survival curve. Artificial neural networks (ANN) are trained to either maximize or minimize this area using a genetic algorithm, and combined into an ensemble to predict one of low, interme

One of the single most cited studies within the field of nonstationary panel data analysis is that of LLC (Levin et al. in J Econom 98:1-24, 2002), in which the authors propose a test for a common unit root in the panel. Using both theoretical arguments and simulation evidence, we show that this test can be misleading unless it is based on the same bandwidth selection rule used by LLC.