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Vascular endothelial growth factor (VEGF) stimulates angiogenesis by activating VEGF receptor-2 (VEGFR-2). The role of its homolog, placental growth factor (PlGF), remains unknown. Both VEGF and PlGF bind to VEGF receptor-1 (VEGFR-1), but it is unknown whether VEGFR-1, which exists as a soluble or a membrane-bound type, is an inert decoy or a signaling receptor for PlGF during angiogenesis. Here,

DNA microarrays can be used to identify gene expression changes characteristic of human disease. This is challenging, however, when relevant differences are subtle at the level of individual genes. We introduce an analytical strategy, Gene Set Enrichment Analysis, designed to detect modest but coordinate changes in the expression of groups of functionally related genes. Using this approach, we ide

This article reports the results of structural studies of poly (-benzyl-L-glutamate) (PBLG) layers self-assembled from dilute solutions in organic solvents on mica surface. Polarized dynamic light scattering and atomic force microscopy were used to study polymer properties in solutions and on the surface. The hierarchy of self-assembly from PBLG solutions in different solvents was investigated as

A systematic review of radiation therapy trials in several tumour types was performed by The Swedish Council of Technology Assessment in Health Care (SBU). The procedures for evaluation of the scientific literature are described separately (Acta Oncol 2003; 42: 357-365). This synthesis of the literature on radiation therapy for uterine cancer is based on data from one randomized study Moreover, da

Vehicle design is characterized by a high number of compromises. The special role of human factors in the process is to ensure that the compromises do not occur at the expense of the driver and passengers. Within the automotive industry there is a need for the development of inexpensive and efficient ergonomic tools, facilitating a fast and cost effective car development process as well as discuss

Popular Abstract in Swedish Denna avhandling består av ett introduktionskapitel, följt av tre kapitel i vilka individens betalningsvilja för att reducera väg- och personbildödsrisken skattas, baserat både på observerade och hypotetiska val. I kapitel 2 används den hedoniska regressionstekniken på den svenska personbilsmarknaden för att skatta värdet av trafiksäkerhet. Resultaten från studien visaThe thesis consists of an introductory chapter, followed by three chapters in which willingness to pay (WTP) for a reduction in car- and road-mortality risk is estimated using both revealed- and stated-preference methods. In chapter 2 the hedonic regression technique is used to estimate the value of traffic safety, using information from the Swedish market for automobiles. The results from the st

Popular Abstract in Swedish Små kyrkor i länder som domineras av andra religioner är ofta beträngda idag. I Malaysia växer sig Islam starkt, och islamistiska rörelser med terroristiska metoder omger landet på alla sidor. Samtidigt har även Buddhism och Hinduism fått nytt liv. Genomgående märks en skärpt hållning visavi den kristna kyrkan och en tilltagande kritik av proselytism. Från Väst finns inProtestantism in Malaysia is in many cases the result of labour migration from China and India in the 19th and 20th Centuries. Under the British colonial administration, it enjoyed a certain degree of protection. Furthermore, in the 20th Century, many Western missions started work in Malaysia often in order to strengthen and expand the ministry of existing denominations. This was particularly true

Background: Serology is often used for the diagnosis of Mycoplasma pneumoniae. It is important to identify specific antigens that can distinguish between the presence or absence of antibodies against M. pneumoniae. The two proteins, P116 and P1, are found to be immunogenic. By using these in ELISA it is possible to identify an immune response against M. pneumoniae in serum samples. Results: A reco

The past decade has witnessed a marked increase in distributed system complexity. This was driven by a maturing technology that steadily decreased the number of faults. Unfortunately these fewer faults have become exponentially more costly. It becomes mandatory to detect faults prior to taking effect on the network. Such an early detection requires a new test, detection and fault containment strat

BACKGROUND. This study was performed in women who had attended the clinic for contraceptive advice to determine whether a history of casual sex with a foreign male, previously unknown to them (SFM) in their home country (Sweden), constituted an increased risk for acquiring sexually transmitted diseases (STD) as compared to women without such an experience (COMP). METHODS. Of 996 women enrolled, an

Alpha-ketoglutarate (AKG) was given to pregnant sows every day starting from the 91(st) d of pregnancy to farrowing. At the same time control pregnant sows were treated in the same way with physiological saline (PhS). Newborn piglets from the experimental (AKG) and control (PhS) mothers were euthanised in 1 h after their birth, and the femora and humeri were isolated and frozen at -25 degrees C un

There is still uncertainty about the frequency of side effects associated with the use of malaria prophylaxis. The biggest concern has been that of meflokin. The aim of the study was to compare different symptoms in travellers taking different prophylactic malaria drugs with a control group travelling to the same area. Travellers seeking advice at a vaccination clinic in the south of Sweden were a

Applying the concept of virtual history, it is possible to reconcile the Soviet history of East Prussia with what came before not only by writing history in a conciliatory and objective manner, but also by presenting the past as one. With this I mean that it is possible to transcend the time dimension and to supersede the notion of history as a chain of events. History need not be written in books

BACKGROUND: To be fully activated platelets are dependent on two positive feedback loops; the formation of thromboxane A2 by cyclooxygenase in the platelets and the release of ADP. We wanted to evaluate the effect of aspirin on platelet function in patients with acute coronary syndromes and we hypothesized that increased levels of ADP in patients with acute coronary syndromes could contribute to a

Popular Abstract in Swedish Denna avhandling har sin upprinnelse i utvecklingen av en metod för datorvisualis-ering och en metod för participativ ingenjörskonst. De två metoderna är intimt förknippade med varandra och benämns tillsammans “Computer Visualization in Participatory Engineering” (VIPE), något som på svenska skulle kunna benämnas ”Datorvisualisering för Participativ Ingenjörsvetenskap”.This thesis tells the initiation story of a computer visualization methodology and a participatory engineering methodology. The two methodologies are tightly coupled and for the purpose of this thesis, as a unit, named Computer Visualization in Par-ticipatory Engineering (VIPE). VIPE aims at a concurrent focus on technical and economical as well as ergonomic demands, by means of advancing communic

Background: Congenital cardiovascular diseases are the most common form of birth defects in humans. A substantial portion of these defects has been associated with inappropriate induction, migration, differentiation and patterning of pluripotent cardiac neural crest stem cells. While TGF-beta superfamily signaling has been strongly implicated in neural crest cell development, the detailed molecula