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A and B antigen levels acquired by group O donor-derived erythrocytes following ABO-non-identical transfusion or minor ABO-incompatible haematopoietic stem cell transplantation

BACKGROUND AND OBJECTIVES: ABO-incompatible haematopoietic stem cell transplantation (HSCT) presents a challenge to blood component transfusion. The aim of this study was to investigate the weak blood group A or B antigen expression by donor-derived group O red blood cells (RBC) observed following transfusion or minor ABO-incompatible HSCT. In addition, in vitro experiments were performed to eluci

Asymptomatic Bacteriuria. Protection against, and differential diagnosis towards symptomatic Urinary Tract Infection.

Urinary tract infections (UTIs) are among the most common infectious diseases in humans, with a subset of susceptible individuals who experience recurrent episodes. The increase in antibiotic resistance in gram-negative uropathogens, due to antibiotic overuse, is a strong rationale for developing therapeutic alternatives and to improve diagnostics. In patients with incomplete bladder emptying (e.gUrinary tract infections (UTIs) are among the most common infectious diseases in humans, with a subset of sus- ceptible individuals who experience recurrent episodes. e increase in antibiotic resistance in gram-negative uropathogens, due to antibiotic overuse, is a strong rationale for developing therapeutic alternatives and to improve diagnostics. In patients with incomplete bladder emptying (e.g

Symptom trajectory and symptom burden in older people with multimorbidity, secondary outcome from the RCT AGe-FIT study

AIM: The aim of this study was to follow the symptom trajectory of community-dwelling older people with multimorbidity and to explore the effect on symptom burden from an ambulatory geriatric care unit, based on comprehensive geriatric assessment.BACKGROUND: Older community-dwelling people with multimorbidity suffer from a high symptom burden with a wide range of co-occurring symptoms often result

Long-Term Evaluation of the Ambulatory Geriatric Assessment : A Frailty Intervention Trial (AGe-FIT): Clinical Outcomes and Total Costs After 36 Months

OBJECTIVE: To compare the effects of care based on comprehensive geriatric assessment (CGA) as a complement to usual care in an outpatient setting with those of usual care alone. The assessment was performed 36 months after study inclusion.DESIGN: Randomized, controlled, assessor-blinded, single-center trial.SETTING: A geriatric ambulatory unit in a municipality in the southeast of Sweden.PARTICIP

Six autoantibodies associated with autoimmune encephalitis are not detectable in the cerebrospinal fluid of suicide attempters

Previous findings suggest a link between neuroinflammatory processes and suicidality. Despite several lines of evidence supporting this link, including increased pro-inflammatory markers in blood-, cerebrospinal fluid (CSF)- and in post-mortem brain samples from suicidal individuals, the underlying mechanisms remain poorly understood. In this pilot study, we explored the possibility that autoimmun

Abnormalities in kynurenine pathway metabolism in treatment-resistant depression and suicidality : a systematic review

Treatment resistant depression (TRD) and suicidal behavior are among the most important public health problems and are commonly associated with significant disability and psychosocial impairment. Although there have been recent advances in identifying neurobiological correlates of these complex conditions, their pathophysiology still remains unclear. Although the recent advances concerning the neu

Problems with Firm-Led Voluntary Sustainability Schemes: The Case of Direct Trade Coffee

Ensuring sustainable consumption and production is one of the United Nations’ Sustainable Development Goals. Sustainable consumption can be supported through regulatory processes. Voluntary private regulatory schemes claiming to contribute to sustainability are a rapidly growing form of regulation. We study one such voluntary sustainability scheme in order to look at the opportunities and challeng

Governance and Politics in the Upper Limpopo River Basin, South Africa

Everyday international political economy (EIPE) offers an opportunity to rethink the role of individuals and citizenry in shaping governance of natural resources. In South Africa, significant progress has been made by government in re-shaping water governance since the end of apartheid in the early 1990s. The role of government in water governance and water politics has thus been emphasised to a l

Reporting on the State of the Environment: South African Experiences

The past few decades have seen an increasing demand for environmental information on which to make more informed decisions, strengthened by several international calls for improving available environmental information. In a democratic South Africa, the involvement of people in policy and decision-making processes has led to an even greater need for accessible information. In response to this deman

Modifying Backoff Freezing Mechanism to Optimize Dense IEEE 802.11 Networks

From experience, it has been well known that the performance of IEEE 802.11 wireless local area networks significantly drops in dense settings, largely driven by poor capacity of the medium access control (MAC) layer. The current 802.11 MAC mechanism utilizes a contention window (CW) for random access, and the CW size is dictated to take discrete values from a bounded finite set. In this paper, wi