The E. coli protein WrbA is an FMN-dependent NAD(P)H: quinone oxidoreductase that has been implicated in oxidative defense. Three subunits of the tetrameric enzyme contribute to each of four identical, cavernous active sites that appear to accommodate NAD(P)H or various quinones, but not simultaneously, suggesting an obligate tetramer with a ping-pong mechanism in which NAD departs before oxidized

Aim. Plasma total adiponectin is a marker of insulin resistance, but its role in predicting cardiovascular events is unclear. We aimed to investigate the role of adiponectin as a predictor of cardiovascular risk in middle-aged men, and to describe the association between adiponectin and glucose metabolism. Methods. In this population-based prospective study of middle-aged men (n=3885), total adipo

In this paper, we study minimal problems related to dual microphone rig self-calibration using TOA measurements from sound sources with unknown positions. We consider the problems with varying setups as (i) if the internal distances between the microphone nodes are known a priori or not. (ii) if the microphone rigs lies in an affine space with different dimension than the sound sources. Solving th

We apply hard pion Chiral Perturbation Theory to charmonium decays to pi pi, KK and eta eta. We first discuss why we expect to be able to provide results for the chiral logarithms in chi(c0) and chi(c2) decays to two pseudoscalars while for the decays from J/psi, psi(nS) and chi(c1) no simple prediction is possible. The leading chiral logarithm turns out to be absent for chi(c0), chi(c2) -> PP. Th

This study presents a state-of-the-art overview on heat transfer characteristics of fluids (mainly water, carbon dioxide and hydrocarbon fuels) flowing in smooth tubes and enhanced tubes at supercritical pressures and tries to obtain a fundamental understanding of the unique characteristics. Heat transfer in enhanced tubes is much better than that in smooth tubes with a larger pressure drop penalt

The emission control in heavy-duty vehicles today is based on predefined injection strategies and after-treatment systems such as SCR (selective catalytic reduction) and DPF (diesel particulate filter). State-of-the-art engine control is presently based on cycle-to-cycle resolution. The introduction of the crank angle resolved pressure measurement, from a piezo-based pressure sensor, enables the p

Objective. To identify if mothers to stillborn babies had had a premonition that their unborn child might not be well and how they dealt with that premonition. Design. A mixed method approach. Setting: 1 034 women answered a web questionnaire. Sample: 614 women fulfilled the inclusion criteria of having a stillbirth after the 22(nd) gestational week and answered questions about premonition. Method

Low temperature is a key factor that limits growth and productivity of many important agronomical crops worldwide. Rice (Oryza sativa L.) is negatively affected already at temperatures below +10°C and is therefore denoted as chilling sensitive. However, chilling tolerant rice cultivars exist and can be commercially cultivated at altitudes up to 3,050 meters with temperatures reaching as low as +4°

Predictions on displacement of suitable habitats due to climate change suggest that plant species with poor colonization ability may be unable to move fast enough to match forecasted climate-induced changes in habitat distribution. However, studies on early Holocene plant migration show fast migration of many plant species that are poor colonizers today We hypothesize that warmer temperatures duri

It has been suggested that organic farming may benefit farmland biodiversity more in landscapes that have lost a significant part of its former landscape heterogeneity. We tested this hypothesis by comparing bird species richness and abundance during the breeding season in organic and conventional farms, matched to eliminate all differences not directly linked to the farming practice, situated in

Background: Prostate cancer screening depends on a careful balance of benefits, in terms of reduced prostate cancer mortality, and harms, in terms of overdiagnosis and overtreatment. We aimed to estimate the effect on overdiagnosis of restricting prostate specific antigen (PSA) testing by age and baseline PSA. Methods: Estimates of the effects of age on overdiagnosis were based on population based

We report on the fabrication of a self-aligned regrown In0.53Ga0.47As metal-oxide-semiconductor field-effect transistor (MOSFET) and a resonant tunneling diode (RTD). The performance of these devices is demonstrated by integrating them in parallel with an inductive coplanar waveguide stub to form a highly energy-efficient 70-GHz wavelet generator. The fast switching and low on-resistance of the MO

A theoretical scheme is presented to calculate non-linear optical spectra of molecules in solution. Starting with electronic structure calculations of the ground and excited state, a subset of vibrational coordinates exhibiting the largest Huang-Rhys factors is assigned. It is used to set up a model Hamiltonian for density matrix multi configurational time-dependent Hartree (MCTDH) calculations. T

Cell death in neurodegenerative diseases is often thought to be governed by apoptosis; however, an increasing body of evidence suggests the involvement of alternative cell death mechanisms in neuronal degeneration. We studied retinal neurodegeneration using 10 different animal models, covering all major groups of hereditary human blindness (rd1, rd2, rd10, Cngb1 KO, Rho KO, S334ter, P23H, Cnga3 KO

Popular Abstract in English In earlier times, patients suffering from mental illness were nursed in large psychiatric institutions, often experiencing extended, sometimes life-long, institutionalization. These institutions were responsible for the patients during the entire course of their lives and provided housing as well as activities along with the care. The patients’ social contacts were mainThe overall aim of this thesis is to 1) investigate the prevalence of stigmatizing experiences and beliefs of devaluation and discrimination among persons with mental illness, and 2) to investigate the relationship between beliefs of devalua¬tion/¬discrimination, rejection experiences and sociodemographic/clinical patient characteristics, social networks, self esteem, empowerment and subjective qu

This paper presents a new framework for solving geometric structure and motion problems based on the L-infinity-norm. Instead of using the common sum-of-squares cost function, that is, the L-2-norm, the model-fitting errors are measured using the L-infinity-norm. Unlike traditional methods based on L-2, our framework allows for the efficient computation of global estimates. We show that a variety