Nya molekyler blockerar vattenkanaler som främjar tumörutveckling I detta projekt upptäcktes två nya molekyler som stänger aquaporin-3, en viktig vattenkanal i våra celler. Projektet kan öppna nya vägar för cancerbehandling genom att inaktivera ett centralt stödsystem för tumörtillväxt. Aquaporiner är små, specialiserade proteiner som bildar kanaler i cellmembranen. De kontrollerar vattenflödet This thesis identified two novel inhibitors of aquaporin-3 with comparable potency to the current leading compound, DFP00173. This achievement was based on the hypothesis that new aquaporin inhibitors could be developed by building upon the chemical structure of DFP00173. Aquaporins are a class of transport proteins responsible for the transport of water through the cell membranes. Aquaporin-3 is

Purpose: To investigate the financial firm characteristics determining investment decisions alongside value creation differences across different investment types and whether private equity investors have a treatment effect on operating firm performance. Theoretical perspectives: The theoretical perspectives of this paper consist of contracting related theories applicable in the private equity env

På bostadsmarknaden har hyrköp införts som en ny form av boende. Hyrköp går ut på att köparen under en tid hyr bostaden med en option om att köpa loss bostaden vid slutet av optionen. Denna upplåtelseform har hittills varit oreglerad enligt lag, vilket kan skapa osäkerhet. I synnerhet vid hyrköpsavtal med fast egendom där avtal om framtida köp enligt praxis inte är bindande. Inom riksdagen har det

Purpose: The purpose of this thesis has been to examine if and how Swedish SMEs use post audit reviews to learn from their capital investment decisions. Methodology: This explorative study applies a qualitative research approach, using both primary and secondary data. The primary data was collected through semi structured interviews with six managers across six different Swedish SMEs, while secon

This Master’s thesis studies the effect of infrasound acoustic waves on heat transfer enhancement for industrial purposes. Previous research has demonstrated the cap ability of infrasound to cool steel uniformly, with performance comparable to forced convection. This opens the possibility of increasing the efficiency of the cooling process while also enabling new potential cooling methods for diff

IMPORTANCE Adherence to the Mediterranean Diet (MedDiet) has been associated with a lower incidence of cancer and reduced weight gain. These associations suggest a potential role for the MedDiet in lowering the risk of obesity-related cancers (ORCs). Obesity is a known risk factor for various cancers and shows an inverse association with MedDiet adherence. OBJECTIVE To examine the association betw

We hypothesize that auditory and motor entrainment evolved in early hominin fetuses in direct response to their mothers’ bipedal footsteps and, later, contributed to the evolution of music and language via two related processes. First, selection for bipedalism transformed feet from grasping into weight-bearing organs, which negatively affected infants’ ability to cling to their mothers, provoking

Importance: Alzheimer disease (AD) predominates in females at almost twice the rate relative to males. Mounting evidence in adults without AD indicates that females exhibit higher tau deposition than age-matched males, particularly in the setting of elevated β-amyloid (Aβ), but the evidence for sex differences in tau accumulation rates is inconclusive. Objective: To examine whether female sex is a

Purpose: Exercise-induced hypohydration exacerbates biomarkers of renal injury, but studies isolating the effects of hypohydration without exercise have produced mixed findings. This study investigated the effects of 24-h severe fluid restriction on biomarkers of renal injury and glucose tolerance. Methods: Fifteen males (age: 27 ± 5 y; BMI: 24.1 ± 3.8 kg/m2) completed two randomised trials, invol

Fastighetstaxeringen utgör en central del av det svenska skattesystemet och syftar till att fastställa det taxeringsvärde som ligger till grund för fastighetsskatt och kommunal fastighetsavgift. Även om lagstiftningen huvudsakligen är värderingsteknisk till sin karaktär, innehåller den bestämmelser om indelning i olika byggnadstyper – något som har direkt betydelse för om och hur en fastighet beskProperty taxation is a key component of the Swedish tax system, serving to determine the assessed value used for levying property tax and the municipal property fee. Although the legislation is primarily valuation-oriented, it also includes provisions on the classification of building types, an element that directly affects whether and how a property is taxed. Buildings classified as "special

Klimatfrågan tar en större och större roll i samhällsbyggnadssektorn, samtidigt står branschen för en betydande del av Sveriges totala utsläpp av växthusgaser. Kommunernas roll i stadsbyggandet är till följd av markägande och planmonopolet betydande, det åligger därför kommunerna att axla ett ansvar i en omställning till en mer klimatanpassad fastighetsbransch. Ett av de verktyg som kommunen kan aThe issue of climate change is taking on an increasingly prominent role in the real estate sector, while the industry itself accounts for a significant share of Sweden’s total greenhouse gas emissions. Due to their land ownership and planning monopoly, municipalities play a central role in urban development and are therefore responsible for leading the transition toward a more climate adapted prop

Key words: Artificial Intelligence, AI Readiness, Implementation, Public Administration, Digitalization, Public Value. Purpose: This study investigates the Swedish Tax Agency's AI readiness across technical, organizational, and environmental dimensions. It also examines whether adoption is driven by rational decision-making or institutional pressures. The research questions are: (1) does the

Purpose: The purpose of this thesis is to investigate how publicly listed real estate companies in Sweden balance formal pre-decision controls with managerial judgement. Methodology: The research approach of this thesis is of a qualitative and exploratory nature. At first, a literature review was conducted in the field. The empirical data was primarily collected through semi-structured interviews

År 2022 stod bygg- och fastighetssektorn för cirka 34 % av Sveriges totala energianvändning, där uppvärmning utgjorde den största andelen. Mot bakgrund av nationella och internationella klimatmål finns ett behov av att minska energianvändningen inom denna sektor. Detta examensarbete syftar till att undersöka hur boendebeteenden påverkar energianvändningen i ett flerbostadshus från 1960-talet, med This thesis investigates how occupant behavior affects energy use in multi-family buildings, with a particular focus on window airing. The study is centered on a 1960s residential building in Malmö, Sweden, equipped with a mechanical exhaust ventilation system. Using a combination of survey responses and measured data from a re-search project, occupant airing habits were analyzed and translated in

Energy-efficient and cost-effective water desalination systems can significantly replenish freshwater reserves without further stressing limited energy resources. Currently, the majority of the desalination systems are operated by non-renewable energy sources such as fossil fuel power plants. The viability of any desalination process depends primarily on the type and amount of energy it utilizes a

The primary aim of the paper is to evaluate whether listed Nordic serial acquirers create short-term abnormal returns at the time of acquisition announcements, and also to determine if serial acquirers experience diminishing returns following additional acquisition announcements, and if concentrated family ownership mitigates the diminishing returns. Theoretical perspectives used include agency t

This article critically explores how the AI image model Stable Diffusion generates visual histories of Scandinavia in the 1930s. While the past has always been mediated, this study suggests that generative AI models constitute a black-boxed yet easily accessible tool for the narration of history. We draw on recent works in digital memory studies and use an explorative hands-on methodology to subje

The paper identifies three interconnected scales of global politics in Artificial Intelligence (AI) and healthcare. It provides a multilevel framework for policy makers to situate hybrid-human AI collaborations in healthcare within broader global political concerns.

Föreställ dig att du bor i ett bostadsområde men tvingas flytta på grund av höjda boendekostnader till följd av stadsförnyelse, som utlovar högre kvalitet i form av ett levande torg och nya gröna parker. Ditt bostadsområde har genomgått en gentrifieringsprocess – något som kan uppstå som en konsekvens av stadsförnyelse. Göteborg är en stad som likt många andra brottas med segregation och samtidiSocial and climate-related challenges are closely intertwined. Existing research has shown that community’s ability to recover from extreme weather events is largely influenced by social vulnerabilities and societal resilience. In response, environmental justice has emerged as a potential tool to address these dual challenges in urban planning. Within this context, strategies such as urban densifi

Sweden’s post-war development positioned it among Europe’s most motorised countries, contributing to high car ownership and widespread reliance on private vehicles. While cars remain essential to modern life, their overuse challenges national climate goals and public health. Efforts to reduce car use have increasingly focused on promoting sustainable al ternatives such as walking, cycling, and pub