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An optical system for measuring nitric oxide using spectral separation techniques

An optical sensor based on differential absorption spectroscopy for real-time monitoring of industrial nitric oxide (NO) gas emission is described. The influence of gas absorption interference from sulfur dioxide (SO2) in the environment was considered and a spectral separation technique was developed in order to eliminate this interference effect. The absorption spectrum of SO2 around 226 nm was

pK(a) Values for the Unfolded State under Native Conditions Explain the pH-Dependent Stability of PGB1.

Understanding the role of electrostatics in protein stability requires knowledge of these interactions in both the folded and unfolded states. Electrostatic interactions can be probed experimentally by characterizing ionization equilibria of titrating groups, parameterized as pK(a) values. However, pK(a) values of the unfolded state are rarely accessible under native conditions, where the unfolded

Classification of mismatch repair gene missense variants with PON-MMR

Numerous mismatch repair (MMR) gene variants have been identified in Lynch syndrome and other cancer patients, but knowledge about their pathogenicity is frequently missing. The diagnosis and treatment of patients would benefit from knowing which variants are disease related. Bioinformatic approaches are well suited to the problem and can handle large numbers of cases. Functional effects were reve

Association of cognitive performance with the metabolic syndrome and with glycaemia in middle-aged and older European men: the European Male Ageing Study

Background and aims Metabolic syndrome has been reported to have adverse effects on cognition although the results are conflicting. We investigated the association between metabolic syndrome and cognitive function in a population sample of middle-aged and older European men and whether any observed association could be explained by lifestyle or other confounding factors. Methods A total of 3369 me

Outcome predictors of intra-articular glucocorticoid treatment for knee synovitis in patients with rheumatoid arthritis - a prospective cohort study

Introduction: Intra-articular glucocorticoid treatment (IAGC) is widely used for symptom relief in arthritis. However, knowledge of factors predicting treatment outcome is limited. The aim of the present study was to identify response predictors of IAGC for knee synovitis in patients with rheumatoid arthritis (RA). Methods: In this study 121 RA patients with synovitis of the knee were treated with

Fast Strain Mapping of Nanowire Light-Emitting Diodes Using Nanofocused X-ray Beams.

X-ray nanobeams are unique nondestructive probes that allow direct measurements of the nanoscale strain distribution and composition inside the micrometer thick layered structures that are found in most electronic device architectures. However, the method is usually extremely time-consuming, and as a result, data sets are often constrained to a few or even single objects. Here we demonstrate that

Natural history of radiographic features of hand osteoarthritis over 10 years

Objectives: To evaluate the natural history of radiographic hand osteoarthritis (OA) over 10 years. Design: We assessed 118 subjects (30 women) twice (X-ray A and B) with mean (SD) follow-up time of 9.6 (0.4) years. Subjects were of mean (SD) age 52 (10) years at X-ray A and had undergone prior knee meniscectomy. Radiographs of the distal interphalangeal (DIP) and proximal interphalangeal (PIP) jo

Effects of changing exposure to neighbourhood greenness on general and mental health: A longitudinal study.

Green neighbourhood environments have been associated with physical and psychological wellbeing in adults. Access to greenness is potentially more important in vulnerable subgroups. In this study based on longitudinal survey data from southern Sweden the cohort was divided into prognostic groups for good self-reported general (n=8891) and mental (n=9444) health. We used independent survey data to

Computational visual ecology in the pelagic realm.

Visual performance and visual interactions in pelagic animals are notoriously hard to investigate because of our restricted access to the habitat. The pelagic visual world is also dramatically different from benthic or terrestrial habitats, and our intuition is less helpful in understanding vision in unfamiliar environments. Here, we develop a computational approach to investigate visual ecology i

Measurements of normalized differential cross sections for t(t)over-bar production in pp collisions at root(s)=7 TeV using the ATLAS detector

Measurements of normalized differential cross sections for top-quark pair production are presented as a function of the top-quark transverse momentum, and of the mass, transverse momentum, and rapidity of the t (t) over bar system, in proton proton collisions at a center-of-mass energy of root s = 7 TeV. The data set corresponds to an integrated luminosity of 4.6 fb(-1), recorded in 2011 with the

Thermal Fluid-Structure-Interaction - Experimental and Numerical Analysis

In the present paper the thermal fluid-structure-interaction is experimentally and numerically investigated. Therefore, the interaction phenomena is modeled by the Reynolds-averaged Navier-Stokes equations and the nonlinear Fourier heat conduction equation are used for the fluid and the solid phase, respectively. The simulation is performed using a partitioned approach using the finite volume meth

Electrospun carbon nanofibers from polyacrylonitrile blended with activated or graphitized carbonaceous materials for improving anodic bioelectrocatalysis.

The electrospun carbon nanofibers obtained from polyacrylonitrile (PAN) and PAN blends with either activated carbon (PAN-AC) or graphite (PAN-GR) were tested as anodes using Shewanella oneidensis MR-1. Extensive physico-chemical and electrochemical characterization confirmed their formation, their fibrous and porous nature, and their suitability as electrodes. N(2) adsorption measurements revealed

High performance MRI simulations of motion on multi-GPU systems

Background: MRI physics simulators have been developed in the past for optimizing imaging protocols and for training purposes. However, these simulators have only addressed motion within a limited scope. The purpose of this study was the incorporation of realistic motion, such as cardiac motion, respiratory motion and flow, within MRI simulations in a high performance multi-GPU environment. Method

Experiences of a Mental Health First Aid Training Program in Sweden: A Descriptive Qualitative Study.

Restricted mental health literacy and stigma are barriers to treatment of mental disorders. A Mental Health First Aid training program was tested for implementation in Sweden among employees in the public sector. The aim of the present qualitative study was to explore participants' experiences of the program in more depth, in conjunction with a randomized controlled study. Twenty four persons part

Photoinduced Electron Transfer in Organic Solar Cells.

Electron transfer (ET) is the key process in light-driven charge separation reactions in organic solar cells. The current review summarizes the progress in theoretical modelling of ET in these materials. First we give an account of ET, with a description originating from Marcus theory. We systematically go through all the relevant parameters and show how they depend on different material propertie

Convergence and specificity in the Arabidopsis MAPK nexus

Although mitogen-activated protein kinase (MAPK) signal transduction cascades are known regulators of various aspects of plant biology, our knowledge of these systems has been largely restricted to a small subset of the MAPKs. However, global analyses are now revealing that many more of these kinases are probably engaged in modulating developmental and fitness adaptation processes in the plant kin

Soluble urokinase plasminogen activator receptor in plasma is associated with incidence of CVD. Results from the Malmö Diet and Cancer Study.

BACKGROUND: Soluble urokinase plasminogen activator receptor (suPAR) is a highly sensitive marker that reflects increased inflammation and is positively correlated with pro-inflammatory biomarkers. The aim of this study was to explore the relationship between suPAR, cardiovascular disease (CVD) risk factors and incidence of CVD. METHODS: suPAR was assessed in a random sample of participants (N=569

Ethical interruption and the creative process - A reflection on the new

Both organizations and management theory seem obsessed with creativity and 'the new,' but lately, the 'newness' of this so-called 'new' has also been questioned. With this paper, I continue in this critical fashion and point to the peculiar fact that the obsession with the new is accompanied by just as strong a rejection of that which is different. Overcoming this paradox, the paper emphasizes the