L-3,4-dihydroxyphenylalanine (L-DOPA) remains the most efficacious drug for the treatment of Parkinson's disease (PD), but causes adverse effects that limit its utility. L-DOPA-induced dyskinesia (abnormal involuntary movements) is a significant clinical problem that attracts growing scientific interest. Current notions attribute the development of dyskinesia to two main factors, viz. the loss of

Enterococcus faecalis haem catalase was crystallized using lithium sulfate at neutral pH. The crystals belong to space group R3, with unit-cell parameters a = b = 236.9, c = 198.1 Angstrom. The three-dimensional structure was determined by molecular replacement using a subunit of the Proteus mirabilis catalase structure. It was refined against 2.3 Angstrom synchrotron data to a free R factor of 21

Stoichiometric Al2O3 films are produced with a pure Al source in the metallic state in an O2+Ar gas mixture using reactive d.c. magnetron sputtering. Substrates as large as 70×100 cm2 are uniformly coated at room temperature while moving in front of the cathode. The key to the success lies in utilizing a sufficiently high working gas pressure and a sufficiently large source-to-substrate distance.

Blood group ABO polymorphism was analysed in genomic DNA isolated from 150 blood donors by restriction endonuclease digestion of three polymerase chain reaction-amplified exons in the ABO genes and by sequencing of randomly selected samples. An anomalous O1 allele first described in a cancer cell line is now shown to account for approximately 40% of the O alleles described to date. This is 10 time

Popular Abstract in Swedish Arbetet avser studier av regnkarakteristik i tid och rum i Kuala Lumpur, Malaysia. I storskalig betraktelse studerades ett 550 km2 område för att bl.a. finna påverkan av monsuner. I skalan av ett avrinningsområde avsåg arbetet en studie av regnets dynamiska egenskaper och rumsliga korrelationsstrukturer. I en enpunktskala, för ett 23 km2 stort område framtogs sannolikheRainfall characteristics of Kuala Lumpur, Malaysia, are studied in space and time; on a large scale, 550 km2, and long term scale to find out the monsoon influence, and on urban basin scale, 23 km2, to determine dynamic properties of rainfalls and spatial correlations, and on a point scale to determine the probabilities of very high rain intensities. The importance of spatial and temporal variabi

Objective: The aim of the study was to determine if artificial neural networks (ANNs) may be useful to analyse a complex and large set of data derived from smoking welders for the purpose of finding relationships between parameters describing respiratory system efficiency and antioxidant defence. Methods: A group of 94 welders employed in a big metallurgic enterprise in Krakow, Poland (men only, a

The emergence of new modes of production, referred to as flexible specialization, post-Fordism or neo-Fordism, has played an important and controversial role in the debate among economic geographers and industrial sociologists. In the discussion assumptions have been made about a process of up-skilling of the work force. In this study a random sample of 351 white- and blue-collar workers in eight

The Trelleborg project ran between 1999 and 2002. This article describes and analyzes the processes relating to institutionalization and social change, and their consequences, within the project. The research, funded by the Swedish National Institute of Public Health, was based on qualitative data collected during the project, including focused interviews with 12 key individuals, five focus group

Abstract not available.

Cellulases hydrolysing the interior parts of cellulose, also called endoglucanases, were immobilised in micro-immobilised enzyme reactors (RIMER) made of porous silicon with the purpose of investigating the use of such mu IMERs for hydrolysis of cellodextrins and soluble cellulose derivatives. The endoglucanases Trichoderma reesei Cel 12A (TrCel 12A) and Bacillus agaradhaerens Cel 5A (BaCel 5A) we

2-Hydroxyethyl methacrylate-L-lactate (HEMA-LLA) and HEMA-L-lactate-dextran (HEMA-LLA-D) were synthesized. H-1-NMR confirmed the formation of these oligomers and macromers. Cryogels with different pore structures were prepared using different amounts of HEMA, HEMA-LLA and HEMA-LLA-D by a cryogelation technique. SEM micrographs exhibited pore morphologies. Cryogels were highly porous with interconn

SU-8 is an epoxy-based photosensitive resist, which is currently used for a large variety of MEMS and lab-on-a-chip applications. Here, we demonstrate a one-step process to functionalise SU-8 with DNA probes. The immobilisation procedure relies on direct coupling of DNA to SU-8 and resulted in surfaces with functional capture probe densities of approximately 10 fmol/mm2 as determined by hybridisat

There is no causal treatment for osteoarthritis. Instead treatment is aimed at decreasing pain and improving function. The base of osteoarthritis treatment is education and exercise. Exercise, both aerobic exercise and muscular strength training, have positive effects on pain and function. The minimum recommendations of exercise are equivalent to the recommendations of physical activity to obtain

Examination of the methylene chloride soluble portion of the acetone extract of the seeds of Turreanthus africanus yielded two labdane diterpenoids 12,15-epoxylabda-8(17),12,14-trien-16-al (1) and 16-acetoxy-12(R),15-epoxy-15β-hydroxylabda-8(17),13(16)-diene (2) and a limonoid, 17-epi 12-dehydroxyheudebolin (3). Structures elucidation was based on the analysis of spectroscopic data.