Amyloid-PET quantification through the tracer-independent Centiloid (CL) scale has emerged as an essential tool for the accurate measurement of amyloid-β (Aβ) pathology in Alzheimer's disease (AD) patients. The AMYPAD consortium set out to integrate existing literature and recent work from the consortium to provide clinical context-of-use recommendations for the CL scale. Compared to histopatholog

Previous research shows that well-grounded knowledge of the intended travellers is essential for achieving successful DRT services. However, there is a lack of understanding of the potential travels in different age groups, and the acceptance of design alternatives that may affect these. Based on surveys conducted in Sweden, this paper investigates these factors in a hypothetical DRT service, in t

Buildings of all types are increasingly becoming complex ‘systems of systems.’ They are subject to evolving societal objectives, new and innovative materials, and in many countries, regulatory ecosystems are having difficulty keeping pace with rapidly changing societal, environmental and technological changes. Two evolving objectives that are stimulating changes to buildings and communities are th

BACKGROUND: Diarrhea is a leading cause of death among children

Synchronizing free-electron laser pulses for time-resolved experiments is necessary as an unsynchronized system reduces the effective repetition rate of the experiment. Additionally, free-electron laser longitudinal coherence and spectral brightness are limited by electron beam energy spread. In this paper, a variable bunch compressor design and compression schemes were developed to: reduce klystr

This paper examines the origins of formal education in colonial Zambia and its long-term consequences for educational attainment and gender inequality. Combining novel panel data on the location of missionary stations and mission school enrolment by gender and missionary society from 1924 to 1953 with contemporary data from the 1990 Zambian census, we ana-lyze the long-term effects of missionary e

Ecosystems worldwide are experiencing a range of natural and anthropogenic disturbances, many of which are intensifying as global change accelerates. Ecological responses to those disturbances are determined by both the vulnerabilities of species and their interspecific interactions. Understanding how individual species contribute to the (in-)stability of an aggregated community property, or funct

Featured Application: Evaluating the effect of train impact velocity, pedestrian position, and station environment on head injury and run-over risk. Application to future safety device design. Introduction: Subway–pedestrian collisions are a significant and growing problem, but they are poorly understood. This study presents the first subway–pedestrian collision model with the aim of evaluating th

En vetenskapligt uppdaterad översikt av industriella revolutionen, med fokus på de inledande faserna i Storbritannien

The tumour microenvironment is programmed by cancer cells and substantially influences anti-tumour immune responses1,2. Within the tumour microenvironment, CD8+ T cells undergo full effector differentiation and acquire cytotoxic anti-tumour functions in specialized niches3–7. Although interactions with type 1 conventional dendritic cells have been implicated in this process3–5,8–10, the underlying

Introduction Delayed palliative management (DPM) is an alternative for prostate cancer (PCa) patients with poor performance status, or those who received radical treatment but progressed and no longer meet the criteria for curative treatment. PIONEER is a large network of federated data analytic platforms in PCa that aims to improve its care through the application of big data analytics. The objec

Horizontal gene transfer is one of the most important drivers of bacterial evolution. Transformation by uptake of extracellular DNA is traditionally not considered to be an effective mode of gene acquisition, simply because extracellular DNA is degraded in a matter of days when it is suspended in e.g. seawater. Recently the age span of stored DNA was increased to at least 2 Ma. Here, we show that

This article explores the representation of the female image in the visual artwork of generative AI and the gender issues in it, using eight different generative AI systems, ERNIE-ViLG 2.0, Shuhua, and Yihui from China and Nightcafe, Fotor, Jasper Art, DALLE and Deep dream generator from the West, as comparative cases. In this paper, female cyborg is selected as a representative of female images,

BACKGROUND Advanced Therapy Medicinal Products (ATMPs) for human use have advanced globally with the rapid adoption of Chimeric Antigen Receptor T-cell (CAR-T) therapies in haemato-oncology. CAR-T cell therapy and ATMPs have unique, significant acute and chronic toxicities, and appropriate patient care is crucial. Significant challenges, including the need for nurse education and training, accompa

Background: Stroke is one of the major chronic non-communicable diseases (NCDs) with high morbidity, disability and mortality. The key to preventing stroke lies in controlling risk factors. However, screening risk factors and quantifying stroke risk levels remain challenging. Methods: A novel prediction model for stroke risk based on two-level feature selection and deep fusion network (SRPNet) is

Women have made substantial gains in education in recent decades and outperformmen in educational attainment across the OECD, but the consequences of this reversal of the gender gap in education (RGE) have not been well researched. In this study, we address the association between the RGE and partnering, employment, and support for a right-wing populist party in Sweden. Of note, we explore the dif

Women have made substantial gains in education and outperform men regarding educational attainment across the OECD, but the consequences of this reversal of the gender gap in education (RGE) have not been well researched. We address the association between the RGE and partnering, employment, and support for a right-wing populist party in Sweden. We explore the differential impacts of women's educa