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Inhibitory CD33-related Siglec receptors regulate immune cell activation upon engaging ubiquitous sialic acids (Sias) on host cell surface glycans. Through molecular mimicry, Sia-expressing pathogen group B Streptococcus binds inhibitory human Siglec-9 (hSiglec-9) to blunt neutrophil activation and promote bacterial survival. We unexpectedly discovered that hSiglec-9 also specifically binds high m
Left ventricular assist devices (LVADs) have dramatically improved short-term outcomes among patients with advanced heart failure. While neurohormonal blockade (NHB) is the cornerstone of treatment for patients with heart failure with reduced ejection fraction, its effect after LVAD placement has not been established. We reviewed medical records of 307 patients who underwent primary LVAD implantat
Tubules formed by self-assembly of organic molecules have a vast potential in nanotechnology applications and the introduction of sensitivity to stimuli into self-assembly tubules represents a particularly attractive feature. Here we report on the preparation and characterization of a molecule obtained by chemical modification of a natural bile acid, a biological surfactant, that self-assembles in
Epidemiological studies have shown a strong association between type 2 diabetes mellitus and cardiovascular diseases, and hypofibrinolysis may contribute to this phenomenon. The aim of this study was to determine the effect of hyperglycaemia on thrombin-activatable fibrinolysis inhibitor (TAR). Hyperglycaemia was mimicked in vitro by incubation of TAFI with glyceraldehyde and in vivo by hyperglyca
Background: Complement is an important mediator in arterial blood pressure-induced vein graft failure. Previously, we noted activation of cell protective mechanisms in human saphenous veins too. Here we have analyzed whether C4b-binding protein (C4bp), an endogenous complement inhibitor, is present in the vein wall. Methods: Human saphenous vein segments obtained from patients undergoing coronary
Near-edge x-ray absorption fine structure (NEXAFS) and resonant inelastic x-ray scattering (RIXS) measurements at the oxygen K edge were combined with theoretical spectrum simulations, based on periodic density functional theory and nuclear quantum dynamics, to investigate the electronic structure and chemical bonding in kaolinite Al2Si2O5(OH)4. We simulated NEXAFS spectra of all crystallographica
Det har länge varit känt att delar av läkares yrkesutövning är av sådan karaktär att den i objektiv mening uppfyller rekvisiten i vissa brottsbestämmelser. Eftersom sjukvården är en önskvärd verksamhet från samhällets sida finns det ett behov av en straffrättslig ansvarsfrihetsregel eller princip som motiverar tillåtligheten i läkares yrkesutövning. I denna uppsats undersöks läkares befogenheter oIt has long been recognized that the professional practice of doctors is of such a nature that in an objective sense it fulfills the requirements of certain criminal acts. Since healthcare is a desirable activity on the part of society, the professional practice of doctors needs to be covered by a discharge from liability that justifies the permissibility of medical practice. This paper examines t
Recent advances in hemophilia prophylaxis have raised the need for accurate noninvasive methods for assessment of early cartilage damage in maturing joints to guide initiation of prophylaxis. Such methods can either be semiquantitative or quantitative. Whereas semiquantitative scores are less time-consuming to be performed than quantitative methods, they are prone to subjective interpretation. To
Cellular reprogramming is the process of converting cells from one cell type to another. The ability to generate specific cell types is useful when constructing models of development and disease, and reprogramming could potentially be used for regenerative therapy in the future. However, applications are limited by the low reprogramming efficiency of existing protocols. The goal of this thesis was
Background: Segmentation of the left atrium (LA) is required to evaluate atrial size and function, which are important imaging biomarkers for a wide range of cardiovascular conditions, such as atrial fibrillation, stroke, and diastolic dysfunction. LA segmentations are currently being performed manually, which is time-consuming and observer-dependent. Methods: This study presents an automated imag
While the Sun is generally more eruptive during its maximum and declining phases, observational evidence shows certain cases of powerful solar eruptions during the quiet phase of solar activity. Occurring in the weak Solar Cycle 14 just after its minimum, the extreme space weather event in 1903 October-November is one of these cases. Here, we reconstruct the time series of geomagnetic activity bas
En populärvetenskaplig artikel om när Lunds universitet fick sina första telefoner, vart de gick och något kort om när universitetet dessutom fick börja betala för sin telefoni.
Patients with peritoneal malignancy treated by cytoreductive surgery (CRS) combined with hyperthermic intraperitoneal chemotherapy (HIPEC) are prone to develop postoperative paralytic ileus (POI). POI is associated with significant increase in both morbidity and mortality. CRS and HIPEC commonly result in prolonged POI (PPOI). The objective was to clarify the extent of PPOI in patients treated by
OBJECTIVE: To predict clinical outcome by classification of peritoneal metastases (PM) of colorectal or appendiceal origin.BACKGROUND: This study investigates whether standardized histological classification can predict outcome for PM of colorectal or appendiceal origin treated with cytoreduction and hyperthermic intraperitoneal chemotherapy (HIPEC).METHODS: Histology of PM (n = 269) was evaluated
OBJECTIVE: To investigate associations between meniscal tear, bone marrow lesions (BMLs), and post-injury knee loading, with cartilage T2 relaxation times on knee magnetic resonance imaging (MRI) in the subacute phase following acute anterior cruciate ligament (ACL) injury.DESIGN: We studied both knees of 128 patients with ACL injury. The presence of meniscal tears and BMLs were determined on suba
Advances in super-resolution microscopy enable the molecular profiling of cells and tissues at the nanoscale level, surpassing the diffraction limit of conventional light microscopy. However, super-resolution techniques typically require access to expensive specialized equipment and extensive training, limiting their broad applicability. Here we provide a detailed protocol for combining expansion
Background: Women are disproportionately affected by migraine, representing up to 75% of all migraine cases. This discrepancy has been proposed to be influenced by differences in hormone levels between the sexes. One such hormone is progesterone. Calcitonin gene-related peptide (CGRP) system is an important factor in migraine pathophysiology and could be influenced by circulating hormones. The pur
