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Fundamentals for a Systematic Approach to Mild and Moderate Inherited Bleeding Disorders : An EHA Consensus Report

Healthy subjects frequently report minor bleedings that are frequently 'background noise' of normality rather than a true disorder. Nevertheless, unexpected or unusual bleeding may be alarming. Thus, the distinction between normal and pathologic bleeding is critical. Understanding the underlying pathologic mechanism in patients with an excessive bleeding is essential for their counseling and treat

Malmö Breast ImaginG database: objectives and development

PurposeWe describe the design and implementation of the Malmö Breast ImaginG (M-BIG) database, which will support research projects investigating various aspects of current and future breast cancer screening programs. Specifically, M-BIG will provide clinical data to: 1. investigate the effect of breast cancer screening on breast cancer prognosis and mortality; 2. develop and validate the use of a

KursbudgetmallHT22 0

Kursbudget Välj kurs HT22 ERROR:#N/A Kursansvarig: Datum: Kursbudget Tilldelning ERROR:#N/A Utgifter Personalkostnader, GU-kont 0 kr Doktorandkostnader 0 kr Personal kostnader, ej GU kont 0 kr Driftskostnader m m 0 kr SUMMA kurskostnader 0 kr RESULTAT ERROR:#N/A Studerandeantal : kostnad/student: ERROR:#DIV/0! Instruktioner: Välj kurs i kurslistan. Då kommer tilldelningen upp. Fyll i datum och nam

https://www.biologyeducation.lu.se/sites/biologyeducation.lu.se/files/2022-06/KursbudgetmallHT22_0.xlsx - 2025-05-31

KursbudgetmallHT23

Kursbudget Välj kurs HT23 ERROR:#N/A Kursansvarig: Datum: Kursbudget Tilldelning ERROR:#N/A Utgifter Personalkostnader, GU-kont 0 kr Doktorandkostnader 0 kr Personal kostnader, ej GU kont 0 kr Driftskostnader m m 0 kr SUMMA kurskostnader 0 kr RESULTAT ERROR:#N/A Studerandeantal : kostnad/student: ERROR:#DIV/0! Instruktioner: Välj kurs i kurslistan. Då kommer tilldelningen upp. Fyll i datum och nam

https://www.biologyeducation.lu.se/sites/biologyeducation.lu.se/files/2023-09/KursbudgetmallHT23.xlsx - 2025-05-31

KursbudgetmallVT23

Kursbudget Välj kurs VT23 ERROR:#N/A Kursansvarig: Datum: Kursbudget Tilldelning ERROR:#N/A Utgifter Personalkostnader, GU-kont 0 kr Doktorandkostnader 0 kr Personal kostnader, ej GU kont 0 kr Driftskostnader m m 0 kr SUMMA kurskostnader 0 kr RESULTAT ERROR:#N/A Studerandeantal : kostnad/student: ERROR:#DIV/0! Instruktioner: Välj kurs i kurslistan. Då kommer tilldelningen upp. Fyll i datum och nam

https://www.biologyeducation.lu.se/sites/biologyeducation.lu.se/files/2022-12/KursbudgetmallVT23.xlsx - 2025-05-31

KursbudgetmallVT23

Kursbudget Välj kurs VT23 ERROR:#N/A Kursansvarig: Datum: Kursbudget Tilldelning ERROR:#N/A Utgifter Personalkostnader, GU-kont 0 kr Doktorandkostnader 0 kr Personal kostnader, ej GU kont 0 kr Driftskostnader m m 0 kr SUMMA kurskostnader 0 kr RESULTAT ERROR:#N/A Studerandeantal : kostnad/student: ERROR:#DIV/0! Instruktioner: Välj kurs i kurslistan. Då kommer tilldelningen upp. Fyll i datum och nam

https://www.biologyeducation.lu.se/sites/biologyeducation.lu.se/files/2023-06/KursbudgetmallVT23.xlsx - 2025-05-31

EndoS2 is a unique and conserved enzyme of serotype M49 group A Streptococcus that hydrolyses N-linked glycans on IgG and α1-acid glycoprotein

Many bacteria have evolved ways to interact with glycosylation functions of the immune system of their hosts. Streptococcus pyogenes [GAS (group A Streptococcus)] secretes the enzyme EndoS that cleaves glycans on human IgG and impairs the effector functions of the antibody. The ndoS gene, encoding EndoS, has, until now, been thought to be conserved throughout the serotypes. However, in the present

Assessment of a new brand of determinants for skin testing in a large group of patients with suspected beta-lactam allergy

Abstract in Spanish Antecedentes: Las pruebas cutáneas con determinantes mayores y menores de la penicilina se utilizan de forma habitual para el diagnóstico de reacciones de hipersensibilidad inmediata a los antibióticos betalactámicos. Estos extractos diagnósticos han sido recientemente retirados del mercado europeo. Objetivo: Estudio de una nueva marca de determinantes para el diagnóstico de reBACKGROUND: Skin testing with major and minor determinants of benzylpenicillin is recommended standard practice for the evaluation of patients with immediate hypersensitivity reactions to beta-lactams. However, commercial reagents for this purpose were recently dropped from the European market. OBJECTIVE: In the present study, we assessed a new brand of reagents for use in skin testing in patients

Calculation of Clothing Insulation by Serial and Parallel Methods: Effects on Clothing Choice by IREQ and Thermal Responses in the Cold

Cold protective clothing was studied in 2 European Union projects. The objectives were (a) to examine different insulation calculation methods as measured on a manikin (serial or parallel), for the prediction of cold stress (IREQ); (b) to consider the effects of cold protective clothing on metabolic rate; (c) to evaluate the movement and wind correction of clothing insulation values. Tests were ca

Combining gas-phase electrophoretic mobility molecular analysis (GEMMA), light scattering, field flow fractionation and cryo electron microscopy in a multidimensional approach to characterize liposomal carrier vesicles

For drug delivery, characterization of liposomes regarding size, particle number concentrations, occurrence of low-sized liposome artefacts and drug encapsulation are of importance to understand their pharmacodynamic properties. In our study, we aimed to demonstrate the applicability of nano Electrospray Gas-Phase Electrophoretic Mobility Molecular Analyser (nES GEMMA) as a suitable technique for

Features of twist extrusion : Method, structures & material properties

During the last decade it has been shown that severe plastic deformation (SPD) is a very effective for obtaining ultra-fine grained (UFG) and nanostructured materials. The basic SPD methods are High Pressure Torsion (HPT) and Equal Channel Angular Extrusion (ECAE). Recently several new methods have been developed: 3D deformation, Accumulative Roll Bonding, Constrained Groove Pressing, Repetitive C

Vitamin D as Supplementary Treatment for Tuberculosis A Double-blind, Randomized, Placebo-controlled Trial

Rationale Vitamin D has been shown to be involved in the host immune response toward Mycobacterium tuberculosis. Objectives: To test whether vitamin D supplementation of patients with tuberculosis (TB) improved clinical outcome and reduced mortality. Methods: We conducted a randomized, double-blind, place-bocontrolled trial in TB clinics at a demographic surveillance site in Guinea-Bissau. We incl

Heat gain from thermal radiation through protective clothing with different insulation, reflectivity and vapour permeability

The heat transferred through protective clothing under long wave radiation compared to a reference condition without radiant stress was determined in thermal manikin experiments. The influence of clothing insulation and reflectivity, and the interaction with wind and wet underclothing were considered. Garments with different outer materials and colours and additionally an aluminised reflective sui

A Bacterial Effector Mimics a Host HSP90 Client to Undermine Immunity

The molecular chaperone HSP90 facilitates the folding of several client proteins, including innate immune receptors and protein kinases. HSP90 is an essential component of plant and animal immunity, yet pathogenic strategies that directly target the chaperone have not been described. Here, we identify the HopBF1 family of bacterial effectors as eukaryotic-specific HSP90 protein kinases. HopBF1 ado

Chemokines modulate glycan binding and the immunoregulatory activity of galectins

Galectins are versatile glycan-binding proteins involved in immunomodulation. Evidence suggests that galectins can control the immunoregulatory function of cytokines and chemokines through direct binding. Here, we report on an inverse mechanism in which chemokines control the immunomodulatory functions of galectins. We show the existence of several specific galectin-chemokine binding pairs, includ

Study of ECG-derived atrial fibrillatory rate for prediction of the outcome of cardioversion of short duration atrial fibrillation (CASAF)

Aims: The present study aimed at testing the hypothesis that atrial fibrillatory rate (AFR) is predictive of sinus rhythm maintenance after electrical cardioversion. Methods and results: The study comprised 32 patients admitted for cardioversion of atrial fibrillation of short duration (mean duration 3.8 ± 7.7 days). AFR was estimated using frequency power spectrum analysis of QRST-cancelled ECG.

CenTauRz : A standardized quantification of tau PET scans

Background: Over the past decade, several PET tracers were developed to visualise and quantify tau pathology in vivo. However, all these tracers have distinct off-target binding, different dynamic ranges and likely different levels of non-specific binding resulting in large variability in semiquantification. We propose to standardise the sampling and the quantification across all available tau tra

Management of mitral stenosis : a systematic review of clinical practice guidelines and recommendations

A number of guidelines exist with recommendations for diagnosis and management of mitral stenosis (MS). We systematically reviewed existing guidelines for diagnosis and management of MS, highlighting their similarities and differences, in order to guide clinical decision-making. We searched national and international guidelines in MEDLINE and EMBASE (5/4/2011-5/9/2021), the Guidelines Internationa