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pH Sensitive Tubules of a Bile Acid Derivative: a Tubule Opening by Release of Wall Leaves

Tubules formed by self-assembly of organic molecules have a vast potential in nanotechnology applications and the introduction of sensitivity to stimuli into self-assembly tubules represents a particularly attractive feature. Here we report on the preparation and characterization of a molecule obtained by chemical modification of a natural bile acid, a biological surfactant, that self-assembles in

Host and pathogen hyaluronan signal through human siglec-9 to suppress neutrophil activation.

Inhibitory CD33-related Siglec receptors regulate immune cell activation upon engaging ubiquitous sialic acids (Sias) on host cell surface glycans. Through molecular mimicry, Sia-expressing pathogen group B Streptococcus binds inhibitory human Siglec-9 (hSiglec-9) to blunt neutrophil activation and promote bacterial survival. We unexpectedly discovered that hSiglec-9 also specifically binds high m

Osteopontin affects insulin vesicle localization and Ca2+ homeostasis in pancreatic beta cells from female mice

Type 2 diabetic patients suffer from insulin resistance and reduced insulin secretion. Osteopontin (OPN), a versatile protein expressed in several tissues throughout the body including the islets of Langerhans, has previously been implicated in the development of insulin resistance. Here we have investigated the role of OPN in insulin secretion using an OPN knock out mouse model (OPN-/-). Ultra-st

The effect of forest owner decision-making, climatic change and societal demands on land-use change and ecosystem service provision in Sweden

The uncertain effects of climatic change and changing demands for ecosystem services on the distribution of forests and their levels of service provision require assessments of future land-use change, ecosystem service provision, and how ecosystem service demands may be met. We present CRAFTY-Sweden, an agent-based, land-use model that incorporates land owner behaviour and decision-making in model

Benefits of Neurohormonal Therapy in Patients With Continuous-Flow Left Ventricular Assist Devices

Left ventricular assist devices (LVADs) have dramatically improved short-term outcomes among patients with advanced heart failure. While neurohormonal blockade (NHB) is the cornerstone of treatment for patients with heart failure with reduced ejection fraction, its effect after LVAD placement has not been established. We reviewed medical records of 307 patients who underwent primary LVAD implantat

Dynamic control of NFV forwarding graphs with end-to-end deadline constraints

There is a strong industrial drive to use cloud computing technologies and concepts for providing timing sensitive services in the networking domain since it would provide the means to share the physical resources among multiple users and thus increase the elasticity and reduce the costs. In this work, we develop a mathematical model for user-stateless virtual network functions forming a forwardin

Non-Invasive Monitoring of Architectural Heritage

Popular Abstract in Swedish Två mobila system, ett svenskt och ett italienskt, för undersökning av historiska fasader har använts för att undersöka möjligheten till identifiering av olika material, biologisk påväxt och faktorer som i framtiden kan leda till nedbrytning av kulturhistoriskt värdefulla monument. Undersökningarna visade på möjligheter att genomföra analyser av ytor med hjälp av fluoreThe on-site documentation and examination of architectural heritage has presented challenges for traditional analysis methods in the form of, among other things, large complex structures, sites and environmental conditions. In recent years there has been growing interest in assessing progressing deterioration processes and material analysis, with an emphasis on sustainable conservation and mainten

Apparent latent heat of evaporation from clothing: attenuation and “heat pipe” effects

Investigating claims that a clothed person’s mass loss does not always represent their evaporative heat loss (EVAP), a thermal manikin study was performed measuring heat balance components in more detail than human studies would permit. Using clothing with different levels of vapor permeability and measuring heat losses from skin controlled at 34°C in ambient temperatures of 10, 20, and 34°C with

Den straffrättsliga nödrättens roll i hälso- och sjukvården

Det har länge varit känt att delar av läkares yrkesutövning är av sådan karaktär att den i objektiv mening uppfyller rekvisiten i vissa brottsbestämmelser. Eftersom sjukvården är en önskvärd verksamhet från samhällets sida finns det ett behov av en straffrättslig ansvarsfrihetsregel eller princip som motiverar tillåtligheten i läkares yrkesutövning. I denna uppsats undersöks läkares befogenheter oIt has long been recognized that the professional practice of doctors is of such a nature that in an objective sense it fulfills the requirements of certain criminal acts. Since healthcare is a desirable activity on the part of society, the professional practice of doctors needs to be covered by a discharge from liability that justifies the permissibility of medical practice. This paper examines t

Quantitative versus semiquantitative MR imaging of cartilage in blood-induced arthritic ankles: preliminary findings

Recent advances in hemophilia prophylaxis have raised the need for accurate noninvasive methods for assessment of early cartilage damage in maturing joints to guide initiation of prophylaxis. Such methods can either be semiquantitative or quantitative. Whereas semiquantitative scores are less time-consuming to be performed than quantitative methods, they are prone to subjective interpretation. To

Simulation of two-phase flow in a heat exchanger distributor application

In this work, compulations of the air/water flow in a distributor were completed with the FLUENT two-phase VOF model and compared to experiments. The parameters of interest concerned the ratio between the deflected mass flow rate of the water phase to the mass flow rate of the water phase at the inlet called the deflection ratio as well as the recreation of the flow pattern of the different two-ph

Theoretical simulations of oxygen K -edge resonant inelastic x-ray scattering of kaolinite

Near-edge x-ray absorption fine structure (NEXAFS) and resonant inelastic x-ray scattering (RIXS) measurements at the oxygen K edge were combined with theoretical spectrum simulations, based on periodic density functional theory and nuclear quantum dynamics, to investigate the electronic structure and chemical bonding in kaolinite Al2Si2O5(OH)4. We simulated NEXAFS spectra of all crystallographica

Arterial Blood Pressure Induces Transient C4b-Binding Protein in Human Saphenous Vein Grafts

Background: Complement is an important mediator in arterial blood pressure-induced vein graft failure. Previously, we noted activation of cell protective mechanisms in human saphenous veins too. Here we have analyzed whether C4b-binding protein (C4bp), an endogenous complement inhibitor, is present in the vein wall. Methods: Human saphenous vein segments obtained from patients undergoing coronary

A clinicopathologic analysis of peritoneal metastases of colorectal and appendiceal origin

OBJECTIVE: To predict clinical outcome by classification of peritoneal metastases (PM) of colorectal or appendiceal origin.BACKGROUND: This study investigates whether standardized histological classification can predict outcome for PM of colorectal or appendiceal origin treated with cytoreduction and hyperthermic intraperitoneal chemotherapy (HIPEC).METHODS: Histology of PM (n = 269) was evaluated

Automated left atrial time-resolved segmentation in MRI long-axis cine images using active contours

Background: Segmentation of the left atrium (LA) is required to evaluate atrial size and function, which are important imaging biomarkers for a wide range of cardiovascular conditions, such as atrial fibrillation, stroke, and diastolic dysfunction. LA segmentations are currently being performed manually, which is time-consuming and observer-dependent. Methods: This study presents an automated imag

Neural tube patterning : from a minimal model for rostrocaudal patterning toward an integrated 3D model

Rostrocaudal patterning of the neural tube is a defining event in vertebrate brain development. This process is driven by morphogen gradients which specify the fate of neural progenitor cells, leading to the partitioning of the tube. Although this is extensively studied experimentally, an integrated view of the genetic circuitry is lacking. Here, we present a minimal gene regulatory model for rost