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Hepatocellular carcinoma (HCC) is associated with high mortality and the current therapy for advanced HCC, Sorafenib, offers limited survival benefits. Here we assessed whether combining the TLR3 agonist: lysine-stabilized polyinosinicpolycytidylic- acid (poly-ICLC) with Sorafenib could enhance tumor control in HCC. Combinatorial therapy with poly-ICLC and Sorafenib increased apoptosis and reduced

SUMMARY: Antibody repertoires reveal insights into the biology of the adaptive immune system and empower diagnostics and therapeutics. There are currently multiple tools available for the annotation of antibody sequences. All downstream analyses such as choosing lead drug candidates depend on the correct annotation of these sequences; however, a thorough comparison of the performance of these tool

Background and objectives: Food is the major factor driving the metabolism of the gut microbiota. In Mexico, nixtamalized corn products are widely consumed. Changes in antioxidant capacity (AOX) in 1,1-Diphenyl-2-picrylhydrazyl (DPPH) and Ferric ion reducing antioxidant power (FRAP), pH values, short-chain fatty acid concentration, and relative metabolite production during in vitro colonic ferment

Humoral immunity is important in limiting clinical disease in malaria, yet the longitudinal B cell response to infection remains unclear. We performed a 1-year prospective study in patients treated for acute Plasmodium falciparum malaria for the first time or with previous exposure to the disease. Using an unbiased exploratory approach with mass cytometry, followed by targeted flow cytometry, we f

Inspirationen till att utforma ett eget material kommer från ett musikaliskt möte där vi tre författare uttryckte intresse för det linjära trumspelet. Ambitionen för själva skapandet grundades även i avsaknaden av ett material för trumslagare på en medelsvår nivå till mer avancerad nivå inom linjärt trumspel. Materialet innehåller ett tydligt syfte, konkreta övningar, tydlig progression och fokus The inspiration to design our own teaching material came from a musical meeting where we expressed an interest in linear drumming. The ambition for the actual creation was based on the lack of a material for drummers at an intermediate level to a more advanced level in linear drumming. The material contains a clear purpose, concrete exercises, clear progression and focus on motivation and creativi

The observed and well-known discrepancy between concentrations of ice nucleating particles in the environment and the concentrations of ice particles in clouds show that there are additional ‘secondary’ processes enhancing the concentrations of ice particles. In present-day modelling of weather and climate, such processes are mostly overlooked and thus a cause for uncertainty. Recent modelling s

Recent studies show associations between transportation noise and various diseases. However, selection bias remains an inherent limitation in many cohort studies. In this study, we aimed to model road traffic noise exposure across the entire Danish population and investigate its distribution in relation to area-level socioeconomic indicators and green space. Based on the Nordic prediction method,

Introduction: Peritoneal metastases (PM) originating from colorectal cancer (CRC) and pseudomyxoma peritonei (PMP) can be treated with cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC). Certain sites in the peritoneal cavity are prone to contain PM and are, therefore, routinely resected. The aim of this study is to investigate the frequency of disease in CRS specime

Standard treatment for patient with peritoneal metastases from colorectal cancer is cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC). In recent years, the efficacy of oxaliplatin-based HIPEC has been challenged. An intensified HIPEC (oxaliplatin+irinotecan) in combination with early postoperative intraperitoneal chemotherapy (EPIC) has shown increased recurrence-fr

This report is about the measurements of swelling gelatine films of different thickness and at different temperature. The research has been mainly focused on finding a suitable model. Results have shown that the new Pseudo-Sigmoidal Model (PSM) is superior to previous quasi-second order models such as the Robinson and Ofner model. It has also been shown that gelatine’s swelling can be divided into

Kursbudget Välj kurs HT21 ERROR:#N/A tc={12BF3CFE-92F6-4F3E-A11B-915CDFB72DA4}: [Trådad kommentar] I din version av Excel kan du läsa den här trådade kommentaren, men eventuella ändringar i den tas bort om filen öppnas i en senare version av Excel. Läs mer: https://go.microsoft.com/fwlink/?linkid=870924 Kommentar: Översiktlig koll påå om tilldelning och antal studenter är med. Kursansvarig: Datum:

https://www.biologyeducation.lu.se/sites/biologyeducation.lu.se/files/2021-12/kursbudgetmall_sv.xlsx - 2026-01-20

The stem of Agave tequilana Weber is used to obtain fructans. Reports on the potential prebiotic activity of agave fructans as ingredients are scarce. The aim of this study was to evaluate the indigestible fraction (IF) content and the short chain fatty acid production (SCFA) from in vitro fermentation of: Native-agavefructans (NAF), agave-dietary-fiber (ADF), high-performance-fructans (HPF), both

A resultant-type identity for univariate polynomials is proved and applied to characterization of SAGBI bases of subalgebras, generated by two polynomials. Besides a new condition for polynomials f(x) and g(x) to form a SAGBI basis, expressed in terms of field extensions is derived.

Several psychiatric disorders, including major depressive disorder (MDD), are associated with increased blood markers of oxidative stress. The relevance of this to the oxidation-sensitive hippocampus (HC) is unknown. We investigated the relationship between peripheral oxidative stress markers and HC volume in unmedicated individuals with MDD (n=16) and healthy controls (n=19). To conserve power, o

Self-assembly of peptides and bile acids has been widely investigated because of their biological role and their potential as a tool for the preparation of nanostructured biomaterials. We herein report both the synthesis and the self-association behavior of a compound that combines the aggregation properties of bile acid- and amino acid-based molecules. The derivative has been prepared by introduc

In sociology, new institutionalists led the revival in interest in institutions in organizational theory and economic sociology by shifting the focus of causal reasoning from agent-centric studies of economic and organizational actors to the relationship connecting the firm with its institutional environment. We suggest a multilevel causal model incorporating the connection between the subinstitut

We report an original and straightforward method for both optical and electrical characterization of vertical GaN nanowire arrays epitaxially grown on silicon through visible-infrared spectroscopic ellipsometry methods. For the initial purpose of adding new inputs to the ellipsometry model, focused ion-beam tomography experiments were conducted to extract porosity/depth profiles of these systems.

The characteristics of the stellar populations in the Galactic bulge info and constrain the Milky Way's foation and evolution. The metal-poor population is particularly important in light of cosmological silations, which predict that some of the oldest stars in the Galaxy now reside in its centre. The metal-poor bulge appears to consist of ltiple stellar populations that require dynamical analyses

Objectives To assess the association between neonatal BCG vaccination and mortality between 28 days and 3 years of age among tuberculosis (TB)-exposed and TB-unexposed children. Design Prospective cohort study. Setting Bandim Health Project runs an urban Health and Demographic Surveillance site in Guinea-Bissau with registration of mortality, vaccination status and TB cases. Participants Children

In this manuscript, we demonstrate the potential of replacing the standard bottom anti-reflective coating (BARC) with a polymethylglutarimide (PMGI) layer for wafer-scale nanofabrication by means of deep-UV displacement talbot lithography (DTL). PMGI is functioning as a developable non-UV sensitive bottom anti-reflective coating (DBARC). After introducing the fabrication process using a standard B