Hepatocellular carcinoma (HCC) is associated with high mortality and the current therapy for advanced HCC, Sorafenib, offers limited survival benefits. Here we assessed whether combining the TLR3 agonist: lysine-stabilized polyinosinicpolycytidylic- acid (poly-ICLC) with Sorafenib could enhance tumor control in HCC. Combinatorial therapy with poly-ICLC and Sorafenib increased apoptosis and reduced

Humoral immunity is important in limiting clinical disease in malaria, yet the longitudinal B cell response to infection remains unclear. We performed a 1-year prospective study in patients treated for acute Plasmodium falciparum malaria for the first time or with previous exposure to the disease. Using an unbiased exploratory approach with mass cytometry, followed by targeted flow cytometry, we f

SUMMARY: Antibody repertoires reveal insights into the biology of the adaptive immune system and empower diagnostics and therapeutics. There are currently multiple tools available for the annotation of antibody sequences. All downstream analyses such as choosing lead drug candidates depend on the correct annotation of these sequences; however, a thorough comparison of the performance of these tool

Standard treatment for patient with peritoneal metastases from colorectal cancer is cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC). In recent years, the efficacy of oxaliplatin-based HIPEC has been challenged. An intensified HIPEC (oxaliplatin+irinotecan) in combination with early postoperative intraperitoneal chemotherapy (EPIC) has shown increased recurrence-fr

The observed and well-known discrepancy between concentrations of ice nucleating particles in the environment and the concentrations of ice particles in clouds show that there are additional ‘secondary’ processes enhancing the concentrations of ice particles. In present-day modelling of weather and climate, such processes are mostly overlooked and thus a cause for uncertainty. Recent modelling s

Consider the communication model (y) over bar = H F (x) over bar + (n) over bar, where H; F are real-valued matrices, (x) over bar is a data vector drawn from some real-valued lattice (e.g. M-PAM), (n) over bar is additive white Gaussian noise and (y) over bar is the received vector. It is assumed that the transmitter and the receiver have perfect knowledge of the channel matrix H (perfect CSI) an

Lymphangiogenesis plays a pivotal role in diverse pathological conditions. Here, we demonstrate that a carbohydrate-binding protein, galectin-8, promotes pathological lymphangiogenesis. Galectin-8 is markedly upregulated in inflamed human and mouse corneas, and galectin-8 inhibitors reduce inflammatory lymphangiogenesis. In the mouse model of corneal allogeneic transplantation, galectin-8-induced

Background: Reduced cerebrospinal fluid (CSF) concentration of amyloid-β1-42 (Aβ1-42) reflects the presence of amyloidopathy in brains of subjects with Alzheimer's disease (AD). Objective: To qualify the use of Aβ1-42/Aβ1-40 for improvement of standard operating procedures (SOP) for measurement of CSF Aβ with a focus on CSF collection, storage, and analysis. Methods: Euroimmun ELISAs for CSF Aβ is

The spatial and spectral filtering characteristics of a microphone array can be greatly enhanced through the use of an appropriately designed spatial/spectral filter. In this paper, we consider the design of optimum, in the minimax sense, spatial/spectral filters. The optimum minimax design problem is solved using the new efficient computational technique of Jiang et al. Numerical results demonstr

Background and objectives: Food is the major factor driving the metabolism of the gut microbiota. In Mexico, nixtamalized corn products are widely consumed. Changes in antioxidant capacity (AOX) in 1,1-Diphenyl-2-picrylhydrazyl (DPPH) and Ferric ion reducing antioxidant power (FRAP), pH values, short-chain fatty acid concentration, and relative metabolite production during in vitro colonic ferment

Alejo Carpentier (1904-1980) is one of the most distinguished writers in Latin American literature and numerous studies have delved into his literary works. However, very little is known about his private life and family background apart from the facts that he chose to reveal about himself. Indeed, several of these “facts” have turned out to be false. This thesis sets out to examine whether a hidd

A review of the geochronology, geochemistry and distribution of the 1380 Ma Mashak Large Igneous Province (LIP) of the eastern margin of the East European craton indicates a potential link to a major breakup stage of the Mesoproterozoic supercontinent Columbia (Nuna), link to a major stratigraphic boundary (Lower-Middle Riphean), and economic significance for hydrocarbons and metallogeny. Specific

Introduction: Peritoneal metastases (PM) originating from colorectal cancer (CRC) and pseudomyxoma peritonei (PMP) can be treated with cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC). Certain sites in the peritoneal cavity are prone to contain PM and are, therefore, routinely resected. The aim of this study is to investigate the frequency of disease in CRS specime

The nitrogen cycle and its effect on carbon uptake in the terrestrial biosphere is a recent progression in earth system models. As with any new component of a model, it is important to understand the behaviour, strengths, and limitations of the various process representations. Here we assess and compare five land surface models with nitrogen cycles that are used as the terrestrial components of so

Recent studies show associations between transportation noise and various diseases. However, selection bias remains an inherent limitation in many cohort studies. In this study, we aimed to model road traffic noise exposure across the entire Danish population and investigate its distribution in relation to area-level socioeconomic indicators and green space. Based on the Nordic prediction method,

Inspirationen till att utforma ett eget material kommer från ett musikaliskt möte där vi tre författare uttryckte intresse för det linjära trumspelet. Ambitionen för själva skapandet grundades även i avsaknaden av ett material för trumslagare på en medelsvår nivå till mer avancerad nivå inom linjärt trumspel. Materialet innehåller ett tydligt syfte, konkreta övningar, tydlig progression och fokus The inspiration to design our own teaching material came from a musical meeting where we expressed an interest in linear drumming. The ambition for the actual creation was based on the lack of a material for drummers at an intermediate level to a more advanced level in linear drumming. The material contains a clear purpose, concrete exercises, clear progression and focus on motivation and creativi

This report is about the measurements of swelling gelatine films of different thickness and at different temperature. The research has been mainly focused on finding a suitable model. Results have shown that the new Pseudo-Sigmoidal Model (PSM) is superior to previous quasi-second order models such as the Robinson and Ofner model. It has also been shown that gelatine’s swelling can be divided into

Programme PROGRAMME —————————————————————————— TRADITION IS THE NEW RADICAL: REMAPPING MASCULINITIES AND FEMININITIES IN THEOLOGY December 12th 13.00-14.00 Registration opens, Entrance of the LUX building 14.00-14.30 Opening of the conference, LUX C216 14.30-16.00 Plenary session I: Key-note by Tina Beattie, "Maternal Matters: Eve, Woman and the Genesis of Gender”, LUX C126 16.00-16.30 Coffee 16.3

https://konferens.ht.lu.se/fileadmin/_migrated/content_uploads/Programme-Tradition_is_the_New_Radical.pdf - 2025-05-31

Språk- och litteraturcentrum Kinesiska 2 LITTERATURLISTA OSHA01, KINAS HISTORIA (15 hp) History of China (15 credits) Fastställd av styrelsen för Sektion 6 2024-12-05 Obligatorisk litteratur Fairbank, John King & Goldman, Merle (2006). China: a new history. Cambridge, MA: Belknap Press of Harvard University Press, 640 s. Gernet, Jacques (1962). Daily Life in China on the Eve of the Mongol Invasion

https://www.sol.lu.se/media/utbildning/dokument/kurser/OSHA01/20251/OSHA01LitteraturlistaRev25.docx - 2025-05-31