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Progressive joint destruction resulting from intra-articular bleeding is the major morbidity affecting patients with haemophilia (PWH), particularly those with inhibitors. Advances in understanding the detrimental processes set in motion by the exposure of joints to bleeding have shaped current management methods. However, to achieve optimal joint health in PWH, in addition to achieving haemostasi
Originally studied in relation to aging and cancer research, telomerase is now also investigated in relation to psychiatric disorders and treatments. Based on emerging clinical and preclinical data, we hypothesise that telomerase activation could represent a novel element mediating the mechanism of action of certain psychopharmacological interventions (e.g. antidepressants, lithium and antipsychot
The center of our disk galaxy, the Milky Way, is dominated by a boxy/peanut-shaped bulge. Numerous studies of the bulge based on stellar photometry have concluded that the bulge stars are exclusively old. The perceived lack of young stars in the bulge strongly constrains its likely formation scenarios, providing evidence that the bulge is a unique population that formed early and separately from t
OBJECTIVES: We examined whether the association between hormone therapy (HT) use and coronary heart disease (CHD) risk differed between women with and without vasomotor symptoms (VMS). STUDY DESIGN: We used data from a Dutch (EPOS) and Swedish (WHILA) population-based sample of 8865 women, aged 46-64 years, and free of CHD, stroke, venous thrombosis/pulmonary embolism or cancer at baseline. Data o
Accelerated cellular aging and reduced lifespan have recently been shown in birds chronically infected with malaria parasites. Whether malaria infection also affects cellular aging in humans has not been reported. Here, we assessed the effect of a single acute Plasmodium falciparum malaria infection on cellular aging dynamics in travelers prospectively followed over one year in Sweden. DNA and RNA
The brain operates at a critical point that is balanced between order and disorder. Even during rest, unstable periods of random behavior are interspersed with stable periods of balanced activity patterns that support optimal information processing. Being born preterm may cause deviations from this normal pattern of development. We compared 33 extremely preterm (EPT) children born at < 27 weeks of
Research has been lacking on the natural history, complications, and treatment of haemophilia B, which is less common than haemophilia A and was recognized as a distinct clinical entity in 1947. Although the two diseases share the same clinical manifestations, they differ in causative mutation, risk of inhibitor development, and patient quality of life. Frequently debated is whether haemophilia B
Trenden i samhällsbyggnadsbranschen visar på ett ökat intresse för innovation. Tidigare forskning har primärt fokuserats på produkt- och processutveckling, där forskningen kring tjänsteinnovation ännu inte fått genomslag. Konsultföretag beskrivs samtidigt som pådrivare av innovation. Detta har öppnat upp för vidare forskning kring hur konsultföretag, som erbjuder tjänster inom förändringsledning i
Background: Although diet has long been suspected as an etiological factor for colorectal cancer, studies of single foods and nutrients have provided inconsistent results. Objective: We used factor analysis methods to study associations between dietary patterns and colorectal cancer in middle-aged Americans. Design: Diet was assessed among 293 615 men and 198 767 women in the National Institutes o
Syftet med denna uppsats var att kartlägga utländska bankers utveckling i Kina samt att studera dess effekter på den kinesiska ekonomin. Uppsatsen är kronologiskt indelad och börjar då de utlänska bankerna gjorde sina första inträden på den kinesiska marknaden under andra hälften av 1800-talet och forsätter in till mitten av 2000-talet. Beskrivningen sker med hjälp av en löpande diskussion av makr
Despite the creativity of the scientific community and the funding agencies, the underlying model of computation behind IoT, WSN, cloud, edge, fog, and mist is fundamentally the same; Computational nodes which are dynamically interconnected to form a system in where both processing capacity and connectivity may vary over time. On top of such a system, we consider applications that need packets to
Elastic and scalable compute resources are a fundamental part of cloud computing. Efficient management of cloud resources is crucial in order to provide high quality services and applications. In this work we present a novel method for scaling cloud resources and provide stability guarantees. We do this by leveraging ideas and concepts from classic control theory, namely mid-range control and combElastic and scalable compute resources are a fundamental part of cloud computing. Efficient management of cloud resources is crucial in order to provide high quality services and applications. In this work we present a novel method for scaling cloud resources and provide stability guarantees. We do this by leveraging ideas and concepts from classic control theory, namely mid-range control and comb
We report on the synthesis of vertical InP nanowire arrays on (001) InP and Si substrates using template-assisted vapour–liquid–solid growth. A thick silicon oxide layer was first deposited on the substrates. The samples were then patterned by electron beam lithography and deep dry etching through the oxide layer down to the substrate surface. Gold seed particles were subsequently deposited in the
The COVID-19 pandemic has wreaked havoc in every country in the world, with serious health-related, economic, and social consequences. Since its outbreak in March 2020, many researchers from different fields have joined forces to provide a wide range of solutions, and the support for this work from artificial intelligence (AI) and other emerging concepts linked to intelligent data analysis has bee
Surface affinity of aqueous guanidinium chloride (GdmCl) is compared to that of aqueous tetrapropylammonium chloride (TPACl) upon addition of sodium chloride (NaCl) or disodium sulfate (Na2SO4). The experimental results have been acquired using the surface sensitive technique X-ray photoelectron spectroscopy on a liquid jet. Molecular dynamics simulations have been used to produce radial distribut
BACKGROUND: The optimal advanced heart failure (HF) therapy strategy for patients aged 60 or older with end-stage HF refractory to optimal medical therapy remains uncertain. This study compares outcomes of three advanced HF therapy strategies in this patient population. METHODS: A single-center retrospective study was conducted in 95 patients aged 60-73 years who had undergone isolated heart trans
In today’s fast moving business environment, organisational change is considered a key requisite to remain competitive, however, organisational change can be a double-edged sword as it can create difficulties for individuals in their identity work carried out in the organisation. Moreover, how individuals conduct their identity work in an organisation can amongst other factors be affected by disco
In modern security systems, the widespread deployment of battery-powered IoT devices creates a critical need for accurate battery replacement strategies. Premature replacement leads to unnecessary waste, while delayed replacement risks system failure in the case of an incident. This thesis presents the workflow building on limited knowledge of the data in an unsupervised learning setting to a work
T-cell development provides an excellent model system for studying lineage commitment from a multipotent progenitor. The intrathymic development process has been thoroughly studied. The molecular circuitry controlling it has been dissected and the necessary steps like programmed shut off of progenitor genes and T-cell genes upregulation have been revealed. However, the exact timing between decisio
