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Introduction: Treatment options for peritoneal metastases (PM) from colorectal cancer (CRC) have increased, their efficiency should be monitored. For this purpose, register-based data on PM can be used, if valid. Purpose: We aimed to evaluate the completeness and positive predictive value (PPV) of synchronous peritoneal metastases (S-PM) registered among CRC patients in the Danish National Patient

Propionic acid (PA) production from agro-industrial residues using propionibacteria has gained interest as an alternative to fossil-based process. Microbial production is however characterized by product inhibition, lowering the product titers and productivity. In this study, Propionibacterium acidipropionici DSMZ4900 was subjected to adaptive evolution to tolerate higher acid concentrations. The

Modeling of the supercritical fluid extraction of solid materials is an important aspect in order to understand and predict the process. A comparison of two empirical models, two semi-empirical models and two mechanistic models is performed using calibration of single experiments. It is concluded that the best fit is obtained using a simple empirical expression. Furthermore, single calibrations di

Let's do the twist: The first twisted bis-amide is obtained by the benzylic oxidation of Tröger's base (TB). Kinetic studies of its acidic hydrolysis reveal that the hydrolysis is to a large extent funneled through doubly protonated species.

Group B Streptococcus (GBS) is a leading cause of invasive bacterial infections in human newborns. A key GBS virulence factor is its capsular polysaccharide (CPS), displaying terminal sialic acid (Sia) residues which block deposition and activation of complement on the bacterial surface. We recently demonstrated that GBS Sia can bind human CD33-related Sia-recognizing immunoglobulin (Ig) superfami

Kraft lignin was used to formulate adhesives in combination with polyethyleneimine, chitosan and soy protein, respectively. The tensile strengths of bond lines formulated with laccase-treated and untreated lignin were found to be similar. However, a remarkable difference was noted when laccase-treated lignin was reduced by sodium borohydride prior to reacting either with chitosan or soy protein -

Consider the communication system model y = HFx+n, where H and F are the channel and precoder matrices, x is a vector of data symbols drawn from some lattice-type constellation, such as M-QAM, n is an additive white Gaussian noise vector and y is the received vector. It is assumed that both the transmitter and the receiver have perfect knowledge of the channel matrix H and that the transmitted sig

An efficient protocol has been developed for the exo-mono and exo,exo-bis functionalization of Tröger's base in the benzylic 6 and 12 positions of the diazocine ring. The lithiation of Tröger's base using s-BuLi/TMEDA followed by electrophilic quench affords exo-mono- and exo,exo-bis-substituted derivatives of Tröger's base in good to excellent yields. The variation of the number of equivalents of

Sialic acid-binding immunoglobulin-like lectins (Siglecs) are receptors believed to be important for regulation of cellular activation and inflammation. Several pathogenic microbes bind specific Siglecs via sialic acid-containing structures at the microbial surface, interactions that may result in modulation of host responses. Recently, it was shown that the group B Streptococcus (GBS) binds to hu

The aim of this investigation is to measure the interface fracture toughness of a woven composite. For this purpose, double cantilever beam (DCB) specimens are tested to measure the load as the delamination grows. The specimen is composed of 15 layers of a carbon-epoxy, balanced weave with alternate layers containing fibers in the directions and the directions. A thin piece of Teflon is placed bet

Conventionally, minimax spatial/spectral filters for microphone arrays are designed by first discretizing the spatial and frequency domains into a finite number of grid points and then performing the optimization over these points. The drawback with this approach is that the response of the spatial/spectral filters in between the grid points can be poor. More recently, an approach that performs th

In anaerobic digestion (AD), the production of short-chain fatty acids (SCFAs) can be beneficial or harmful to the overall process, depending on the concentration of accumulated acids. Therefore, the accurate determination of the SCFA concentration in both fresh and stored sludge hydrolysates is important. To select a suitable method for monitoring SCFAs during the AD of sewage sludge, the accurac

The BioCyc database collection is a set of 160 pathway/genome databases (PGDBs) for most eukaryotic and prokaryotic species whose genomes have been completely sequenced to date. Each PGDB in the BioCyc collection describes the genome and predicted metabolic network of a single organism, inferred from the MetaCyc database, which is a reference source on metabolic pathways from multiple organisms. I

HVAC systems have the purpose of improving indoor air quality in buildings to enhance appropriate occupants- comfort, health and good productivity. Window airing may be one measure to consider in the absence of occupant control of the ventilation and by that, we mean occupants opening windows and doors. Approximating the volume of air exchanged during window airing is important in understanding th

Depicting developmental processes as movements in free energy genetic landscapes is an illustrative tool. However, exploring such landscapes to obtain quantitative or even qualitative predictions is hampered by the lack of free energy functions corresponding to the biochemical Michaelis– Menten or Hill rate equations for the dynamics. Being armed with energy landscapes defined by a network and its

In this study, a rapid and sensitive ultra-high performance supercritical fluid chromatography-mass spectrometry (UHPSFC-MS) method has been developed and partially validated for the separation of carotenoids within less than 6 min. Six columns of orthogonal selectivity were examined, and the best separation was obtained by using a 1-aminoanthracene (1-AA) column. The length of polyene chain as we

Two dolerite dyke swarms are recognized along and paralleling the Ural Mountains, Russia. The Uralian swarm is 1400-km long (2300-km long if traced from its inferred plume centre). Further north, the Pay-Khoy swarm can be traced through the Pay-Khoy–Novaya Zemlya fold belt for a distance of c. 250 km (800-km long if traced from its inferred plume centre). An Upper Devonian age for volcanism associ

Recent advances in therapeutics are now providing a wide range of options for adults and children living with hemophilia. Although therapeutic choices are also increasing for the youngest individuals with severe disease, challenges remain about early management decisions, as supporting data are currently limited. Parents and healthcare professionals are tasked with helping children achieve an incl