We report pulse energy scaling enabled by the use of Laguerre-Gaussian single-vortex (LG0,l) beams for spectral broadening in a sub-40 cm long Herriott-type bulk multi-pass cell. Beams with orders l=1−3 are generated by a spatial light modulator, which facilitates rapid and precise reconfiguration of the experimental conditions. 180 fs pulses with 610 uJ pulse energy are post-compressed to 44 fs u

Anaplastic lymphoma kinase (ALK) is a tyrosine kinase receptor which has been implicated in numerous solid and hematologic cancers. ALK mutations are reported in about 5-7% of neuroblastoma cases but the ALK-positive percentage increases significantly in the relapsed patient population. Crizotinib, the first clinically approved ALK inhibitor for the treatment of ALK-positive lung cancer has had le

BACKGROUND: Diagnostic methods for the study of allergic reactions to Anisakis simplex (A.s.) based on whole-body extracts of the larva are clearly insufficient. OBJECTIVES: To study the allergenicity of the proteins secreted by the parasite. Comparison with somatic antigens and determination of their clinical importance in allergic patients were also addressed. METHODS: An excretory/secretory (E/

Purpose The author aims to gain a detailed understanding of the different supply chain actors’ perspectives on sustainable supply chain management and its implementation in the process of a global chemistry manufacturer in Turkey. In order to identify what is missing and hindering the implementation of sustainability in SCM as well as the opportunities which arise out of SSCM for both company and

The current conjecture towards Nordic fertility rates brings the focus on the state of advancement of the second demographic transition (SDT) in the region. Nordic countries’ SDT developments have been unique as they have not experienced the same low fertility as other countries. Yet, since 2010, Iceland lost nearly a quarter of its fertility and reached an all-time low total fertility rate (TFR)

This thesis examines how the Swedish Armed Forces communicates its visual identity through Instagram, one of the most popular social media platforms today. The purpose is to analyze which visual elements the Swedish Armed Forces use to express their identity, which visual elements appear most in their Instagram posts, and how their existing visual identity manual is reflected on the platform. We a

Overheating in buildings is becoming a major concern and cause for various health issues. Existing research and previous studies on the issue were examined to acquire relevant information about the definition of overheating, its possible causes, and the heath impacts it could have on human health. The review included data on the current status of thermal comfort and overheating regulations in Swed

Syfte: Studiens syfte är att undersöka om det i teorin beskrivs faktorer inom hur man framgångsrikt kommunicerar en förändringsprocess som inte appliceras i praktiken, vilket i så fall kan ligga till grund för att en så stor del av förändringsprocesser inte implementeras. Metod: En kvalitativ tvärsnittsstudie utifrån en deduktiv ansats. Uppsatsens empiriska material insamlades genom semistrukturerObjective: The objective of this dissertation is to investigate whether relevant theory describes certain elements that facilitates communicating a change process successfully, which are not applied in practice and could thus constitute for the large amount of change processes that are never implemented. Method: A cross-sectional study with a deductive and qualitative approach. The dissertations’

Background: Vitamin A may have some influence on the immune system, but the role in allergy modulation is still unclear. Objective: To clarify whether high levels of retinoic acid (RA) affects allergic response in vivo, we used a murine experimental model of airway allergic disease. Methods: Ovalbumin (OVA)-immunization/OVA-challenge (OVA/OVA) and house dust mite (HDM)-immunization/HDM-challenge (

A brief introduction to convolutional coding is given. The active distances are reviewed and shown to be an important tool for analyzing the error correcting capability of maximum-likelihood (ML) decoding of convolutional codes when communicating over a binary symmetric channel (BSC). Due to memory and delay constraints in practical coding schemes, convolutional codes often are either terminated o

Denna uppsats syftar till att fastställa hur införandet av Enhetliga Patent och den Europeiska- och EU-patentdomstolen kommer att påverka läkemedelsindustrins val av patentansökningsförfarande när de ansöker om patent i Europa i framtiden. För att fastställa de förväntade effekterna av Enhetliga Patent på branschen har intervjuer med ett urval personer inom forskning- och utvecklingsföretag och enThis thesis aims to establish how the introduction of the Unitary Patent and the European and European Union Patent Court will affect the pharmaceutical industry’s choice of patent application route when applying for patents in Europe in the future. To establish the expected effect of the Unitary Patent on the industry interviews with a selection of professionals in the research and development in

I uppsatsen studerar jag hur Institutet för arbetsmarknadspolitisk utvärdering (IFAU) har följt upp och utvärderat det svenska friårsförsöket. Jag undersöker om deras tillvägagångssätt stämmer överens med hur man teoretiskt bör följa upp och utvärdera arbetsmarknadspolitiska program. Hemström med fleras (2002) ”Att följa upp och utvärdera arbetsmarknadspolitiska program” ligger som huvudsaklig teo

Glypicans are linked to various aspects of neoplastic behavior, and their therapeutic value has been proposed in different cancers. Here, we have systematically assessed the impact of GPC4 on cancer progression through functional genomics and transcriptomic analyses across a broad range of cancers. Survival analysis using TCGA cancer patient data reveals divergent effects of GPC4 expression across

We report on a computational study of resonant inelastic x-ray scattering (RIXS), at different fluorine K-edge resonances of the SF6 molecule, and corresponding nonresonant x-ray emission. Previously measured polarization dependence in RIXS is reproduced and traced back to the local σ and π symmetry of the molecular orbitals and corresponding states involved in the RIXS process. Also electron-hole

Rapporten undersöker hur brusreducering påverkar ljudklassificering. Olika aspekter undersöks; informationsbevarande, hur bra brusreduceringen blir, samt brusnivåers och antalet klassers inverkan. Ljudklassificering är när en dator analyserar ljud och identifierar vilka klasser ljudet tillhör. För att skapa klassificering med maskininlärning, tränas ett nätverk att till bästa förmåga klassificerIt is often impossible to capture the sound one wants without capturing noise. Consequently, research has been done on noise filtering in audio signals. Currently deep learning algorithms are used for noise filtering. This thesis investigated the effects of noise and denoising on sound classification. The thesis used two standard datasets for clean sound and noise. FSD50K was chosen as clean soun

This study investigates the activist engagement strategies of U.S.-domiciled hedge funds when engaging with Japanese firms. The study forms a comparison of the engagement strategies both before Japan’s 2015 Corporate Governance Code and after. To create this comparison, two campaigns were examined. First, the U.S.-domiciled hedge fund Steel Partners and its campaign against Japanese firm Bull-Dog

Laccase catalysed oxidation of syringyl and guaiacyl subunits of lignin and their modification with an aromatic amine, p-aminobenzoic acid (PABA) were investigated. Laccase from Galerina sp. HC1 isolated earlier by us was used as the main catalyst, and Trametes versicolor laccase was used for comparison. Among the syringyl compounds, syringic acid and syringaldehyde were oxidised to 2,6-dimethoxy-

Because of the amphiphilic properties of alcohols, hydrophobic hydration is important in the alcohol-water system. In the present paper we employ X-ray photoelectron spectroscopy (XPS) to investigate the bulk and surface molecular structure of ethanol-water mixtures from 0.2 to 95 mol %. The observed XPS binding energy splitting between the methyl C 1s and hydroxymethyl C 1s groups (BES-[CH3-CH2OH