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Telomere repeats at chromosomal ends, critical for genomic integrity, undergo age-dependent attrition and telomere length has been associated with different disorders including cancers. In this study, based on 1469 patients and 1158 healthy controls, we show a statistically significant (P = 6 × 10-10 ) association between increased telomere length and melanoma risk. Mendelian randomization, using
A novel DCV-system controls the air-change rate for each apartment in multifamily buildings based on two indoor air parameters: 1) the moisture load (supply), and 2) volatile organic compounds. With a central fan, but decentralized control boxes placed outside each apartment, the system controls the air-change rate for each apartment. This paper’s main aim is to determine the potential of this DCV
A detailed mapping of the dominant kinematical domains contributing to the prompt atmospheric neutrino flux at high neutrino energies is presented by studying their sensitivity to the cuts on several kinematical variables crucial for charm production in cosmic ray scattering in the atmosphere. This includes the maximal center-of-mass energy for proton-proton scattering, the longitudinal momentum f
Urban water systems are facing growing challenges, including climate change and aging assets. Digital transformation presents opportunities to address these issues. However, water utilities often encounter barriers such as fragmented initiatives, organizational inertia, and lack of systems interoperability, limiting the scalability and impact of digitalization efforts. This paper presents a strate
We investigate subalgebras of finite codimension in. In earlier work we have introduced a way of describing such subalgebras in terms of their so called (subalgebra) spectrum and a set of conditions for subalgebra membership that can be expressed by evaluating polynomials and their derivatives in points of the spectrum only. In this paper we focus on subalgebras with a single element in their spec
Constructions of woven graph codes based on constituent block and convolutional codes are studied. It is shown that within the random ensemble of such codes based on s-partite, s-uniform hypergraphs, where s depends only on the code rate, there exist codes satisying the Varshamov-Gilbert (VG) and the Costello lower bound on the minimum distance and the free distance, respectively.
Syftet med studien var att explorativt undersöka sambandet mellan social identitet och egen attityd till klimatvänligt beteende och klimatfrågan. Mer specifikt ämnade studien att undersöka huruvida stark identifikation med sju olika sociala identiteter och tillskriven gruppattityd korrelerar med egen attityd. Tvåhundrasextiofyra personer (N=264) deltog i studien genom en digital enkät. Den statistThe aim of the present study was to explore the relationship between social identity and personal attitude towards climate-friendly behaviour and the climate crisis. More specifically, the aim was to investigate whether strong identification with seven different social identities and ascribed group attitude correlates with personal attitude. Two-hundred and sixty-four persons (N=264) participated
Kombinerad bioetanol- och biogas-produktion från vetehalm. Genom ökad torrhalt vid fermentering, samt biogasproduktion från restprodukter, kan lönsamheten för biobränslen att öka. Ökande miljöproblem gällande växthusgaser är ständigt i fokus. År 2007 gav det europeiska parlamentet nya direktiv gällande energipolitiken, där målen var att växthusgaserna i Europa ska reduceras med 20% och att minst 1Currently the production cost of lignocellulosic ethanol is considered to be relatively high. Large fractions of the production cost come from the raw material and the energy consumed in the distillation. Therefore it is desirable to have a process that yields high concentration of ethanol and maximizes the utilization of the biomass. Wheat straw is a promising raw material for lignocellulosic eth
För att säkerställa finansiell stabilitet och undvika framtida ekonomiska kriser är det viktigt att banker noggrant hanterar sin kreditrisk. En kritisk komponent i detta är att noggrant modellera sannolikheten för att en låntagare inte kan återbetala sitt lån, även känt som sannolikheten för konkurs (Probability of Default, PD). Mitt examensarbete fokuserar på att förbättra dessa förutsägelser genThis thesis investigates the application of spline regression models to predict the Probability of Default (PD) under varying macroeconomic conditions, exploring whether these models can enhance predictive accuracy over traditional linear models and compare favorably to XGBoost. The study analyses the non-linear dynamics between PD and key macroeconomic indicators within a Swedish small-sized corp
Problembeskrivning: I retailbranschen, som är en personalintensiv bransch, ställs det allt högre krav på servicen i butiken. Om företaget kan förmedla en upplevelse av hög kvalitet genom bra service skapas lojala och nöjda kunder. Dålig optimering av personal i butiken kan vara kostsamt och ge upphov till dålig service. Syfte och Frågeställningar: Syftet med uppsatsen är att belysa vikten av att a
The global pharmaceutical market has been the subject of considerable controversy in both the public and academic debate. Much of the controversy has centred around European price controls and the right of pharmaceutical manufacturers to independently set prices. This subject of this paper in one of the tools used by the EU governments control prices; namely parallel trade. The empirical research
Glypicans are linked to various aspects of neoplastic behavior, and their therapeutic value has been proposed in different cancers. Here, we have systematically assessed the impact of GPC4 on cancer progression through functional genomics and transcriptomic analyses across a broad range of cancers. Survival analysis using TCGA cancer patient data reveals divergent effects of GPC4 expression across
We report on a computational study of resonant inelastic x-ray scattering (RIXS), at different fluorine K-edge resonances of the SF6 molecule, and corresponding nonresonant x-ray emission. Previously measured polarization dependence in RIXS is reproduced and traced back to the local σ and π symmetry of the molecular orbitals and corresponding states involved in the RIXS process. Also electron-hole
New therapeutic agents for haemophilia with inhibitors that are in development or already licensed are expected to provide transformative treatment options. Many of these new therapies are not based on simply replacing the missing factor; new strategies include bispecific antibody technology that mimics factor VIII coagulation function (emicizumab), and inhibition of anticoagulant proteins such as
We report pulse energy scaling enabled by the use of Laguerre-Gaussian single-vortex (LG0,l) beams for spectral broadening in a sub-40 cm long Herriott-type bulk multi-pass cell. Beams with orders l=1−3 are generated by a spatial light modulator, which facilitates rapid and precise reconfiguration of the experimental conditions. 180 fs pulses with 610 uJ pulse energy are post-compressed to 44 fs u
Anaplastic lymphoma kinase (ALK) is a tyrosine kinase receptor which has been implicated in numerous solid and hematologic cancers. ALK mutations are reported in about 5-7% of neuroblastoma cases but the ALK-positive percentage increases significantly in the relapsed patient population. Crizotinib, the first clinically approved ALK inhibitor for the treatment of ALK-positive lung cancer has had le
A brief introduction to convolutional coding is given. The active distances are reviewed and shown to be an important tool for analyzing the error correcting capability of maximum-likelihood (ML) decoding of convolutional codes when communicating over a binary symmetric channel (BSC). Due to memory and delay constraints in practical coding schemes, convolutional codes often are either terminated o
Laccase catalysed oxidation of syringyl and guaiacyl subunits of lignin and their modification with an aromatic amine, p-aminobenzoic acid (PABA) were investigated. Laccase from Galerina sp. HC1 isolated earlier by us was used as the main catalyst, and Trametes versicolor laccase was used for comparison. Among the syringyl compounds, syringic acid and syringaldehyde were oxidised to 2,6-dimethoxy-
BACKGROUND: Diagnostic methods for the study of allergic reactions to Anisakis simplex (A.s.) based on whole-body extracts of the larva are clearly insufficient. OBJECTIVES: To study the allergenicity of the proteins secreted by the parasite. Comparison with somatic antigens and determination of their clinical importance in allergic patients were also addressed. METHODS: An excretory/secretory (E/
Background: Vitamin A may have some influence on the immune system, but the role in allergy modulation is still unclear. Objective: To clarify whether high levels of retinoic acid (RA) affects allergic response in vivo, we used a murine experimental model of airway allergic disease. Methods: Ovalbumin (OVA)-immunization/OVA-challenge (OVA/OVA) and house dust mite (HDM)-immunization/HDM-challenge (
