Importance: There are limitations in current diagnostic testing approaches for Alzheimer disease (AD). Objective: To examine plasma tau phosphorylated at threonine 217 (P-tau217) as a diagnostic biomarker for AD. Design, Setting, and Participants: Three cross-sectional cohorts: an Arizona-based neuropathology cohort (cohort 1), including 34 participants with AD and 47 without AD (dates of enrollme

Individuals with severe self-harm and experiences of lengthy psychiatric admissions often have complex mental health conditions and are at risk of suicide. In this qualitative study, self-harming individuals with >180 days of psychiatric admission over 12 months shared their experiences of Brief Admission (BA), a standardized crisis-management intervention encouraging self-admission and autonomy.

Context:: Software-intensive organizations’ rationale for sharing Open Source Software (OSS) may be driven by both idealistic, strategic and commercial objectives, and include both monetary as well as non-monetary benefits. To gain the potential benefits, an organization may need to consider what they share and how, while taking into account risks, costs and other complexities. Objective:: This st

Given a Boolean formula, the problem of counting seeks to estimate the number of solutions of F while the problem of uniform sampling seeks to sample solutions uniformly at random. Counting and uniform sampling are fundamental problems in computer science with a wide range of applications ranging from constrained random simulation, probabilistic inference to network reliability and beyond. The pas

AIM: Fibroblast growth factor 21 (FGF21) has recently been implicated in thirst in rodent models. The mechanisms for this are currently uncertain, and it is unclear whether hydration status can alter FGF21 concentrations, potentially providing an additional mechanism by which hypohydration induces thirst. The aim of this study is therefore to understand whether hydration status can alter circulati

Purpose: Grounded in paradox theory, and with the objective of structuring and extending existing knowledge of conflicts of interest (e.g. trade-offs) in packaging logistics, the purpose of this paper is to identify categories of paradoxical tensions in packaging systems used in supply chains, and to develop a conceptual framework that describes these categories. Design/methodology/approach: This

Aim: To explore the experience of pain in 10- to 12-year-old children. Methods: This interview study included students (n = 42) in grade 4-6 in focus groups (n = 10) in southern Sweden (52% girls); mean age, 11.3 years (range 10-12 years). The interviews were audio-recorded and transcribed verbatim and analysed with qualitative content analysis. Results: The analysis resulted in one theme: Pain as

One important question concerning a risk description is to what extent it should contain information about the uncertainty surrounding an estimated probability for an event, for example, by using some form of probability range. Presenting a point estimate together with a range can inform the decision-maker about both the best judgement as well as the strength of knowledge regarding the probability

Do the misty mountains, fast-flowing rivers, and sandy beaches leave you in awe and fill you with insatiable wonder? Does nature bring you a jubilant feeling? Nature contributes to our quality of life in multiple ways. Some of these gifts are easily visible, like the clothes you wear, the food you eat, and the water your drink. However, some contributions, such as flood protection and pollination

In many financial applications, it is important to classify time-series data without any latency while maintaining persistence in the identified states. The authors propose a greedy online classifier that contemporaneously determines which hidden state a new observation belongs to without the need to parse historical observations and without compromising persistence. Their classifier is based on tIn many financial applications, it is important to classify time-series data without any latency while maintaining persistence in the identified states. The authors propose a greedy online classifier that contemporaneously determines which hidden state a new observation belongs to without the need to parse historical observations and without compromising persistence. Their classifier is based on t

OBJECTIVE: The prevalence of type 2 diabetes is rising rapidly in low-income and middle-income countries (LMICs), but the factors driving this rapid increase are not well understood. Adult height, in particular shorter height, has been suggested to contribute to the pathophysiology and epidemiology of diabetes and may inform how adverse environmental conditions in early life affect diabetes risk.

Previous research has documented intergenerational transmission of human capital from children to parents. Less is known, however, about heterogeneity in this 'upward transmission' in low-resource settings. We examine whether co-resident adult children's education is associated with improved health among older parents in India, using nationally representative data from the 2014 Indian National Sam

Trots likadana tekniska förutsättningar visade den aktuella avhandlingen på att energianvändningen varierade stort mellan hushåll – vilket även tidigare forskning pekat på. Det skiljde en faktor två till tre mellan högsta och lägsta energianvändningen för de grupper av likadana hus som studerades. Skillnaden i vattenanvändning var ännu större, nämnare bestämt en faktor sex. De boendes val och vardTo achieve global energy goals, energy use in residential buildings must decrease. The implementation of technical measures is crucial but alone it is not sufficient; residents need to change their behaviour as well. However, households are not a homogeneous group in terms of their energy use and behaviour; rather, the use varies between households and over time. To promote energy savings in build

More than a third of the world population is currently under some form of partial or total lockdown to limit morbidity and mortality due to covid-19. Whereas these measures are working, they are exerting an unprecedented negative socio-economic impact on the general wellbeing, and thus may not be sustained for long. Alternative control measures that limit the spread of the virus and yet facilitate

According to Silvan Tomkins' polarity theory, ideological thought is universally structured by a clash between two opposing worldviews. On the left, a humanistic worldview seeks to uphold the intrinsic value of the person; on the right, a normative worldview holds that human worth is contingent upon conformity to rules. In this article, we situate humanism and normativism within the context of con

In this paper, an adaptive design methodology for synthesizing a harmonic free N-path filter with reduced frequency folding is presented. System level analysis of proposed architecture shows that by adding a few extra paths with proper weights to a conventional N-path filter, several characteristics such as harmonic rejection, power reduction, foldback elimination and spectrum shaping can be achie

This paper addresses the challenge of achieving profitable city logistics initiatives. A case study examines the financial continuity of one such initiative in Sweden by exploring its cost structure, the relative importance of its revenue variables, and the variables that determine the economy of scale. The results show the potential of obtaining a viable business model and provide new insights in

In this paper, we will explore the theme of the documentation of 3D cultural heritage assets, not only as entire artefacts but also including the interesting features of the object from an archaeological perspective. Indeed, the goal is supporting archaeological research and curation, providing a different approach to enrich the documentation of digital resources and their components with correspo

Disease recurrence in surgically treated lung adenocarcinoma (AC) remains high. New approaches for risk stratification beyond tumor stage are needed. Gene expression-based AC subtypes such as the Cancer Genome Atlas Network (TCGA) terminal-respiratory unit (TRU), proximal-inflammatory (PI) and proximal-proliferative (PP) subtypes have been associated with prognosis, but show methodological limitat