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The shelterin complex protects chromosomal ends by regulating how the telomerase complex interacts with telomeres. Following the recent finding in familial melanoma of inactivating germline mutations in POT1, encoding a member of the shelterin complex, we searched for mutations in the other five components of the shelterin complex in melanoma families.
BACKGROUND: We report the development of a cutaneous melanoma risk algorithm based upon seven factors; hair color, skin type, family history, freckling, nevus count, number of large nevi, and history of sunburn, intended to form the basis of a self-assessment Web tool for the general public.METHODS: Predicted odds of melanoma were estimated by analyzing a pooled dataset from 16 case-control studie
Malignant cells, like all actively growing cells, must maintain their telomeres, but genetic mechanisms responsible for telomere maintenance in tumors have only recently been discovered. In particular, mutations of the telomere binding proteins alpha thalassemia/mental retardation syndrome X-linked (ATRX) or death-domain associated protein (DAXX) have been shown to underlie a telomere maintenance
Soil carbon (C) is a critical component of Earth system models (ESMs), and its diverse representations are a major source of the large spread across models in the terrestrial C sink from the third to fifth assessment reports of the Intergovernmental Panel on Climate Change (IPCC). Improving soil C projections is of a high priority for Earth system modeling in the future IPCC and other assessments.
Parmelioid lichens are a diverse and ubiquitous group of foliose lichens. Generic delimitation in parmelioid lichens has been in a state of flux since the late 1960s with the segregation of the large, heterogeneous genus Parmelia into numerous smaller genera. Recent molecular phylogenetic studies have demonstrated that some of these new genera were monophyletic, some were not, and others, previous
Post-traumatic stress disorder (PTSD) impacts many veterans and active duty soldiers, but diagnosis can be problematic due to biases in self-disclosure of symptoms, stigma within military populations, and limitations identifying those at risk. Prior studies suggest that PTSD may be a systemic illness, affecting not just the brain, but the entire body. Therefore, disease signals likely span multipl
Current global change substantially threatens pollinators, which directly impacts the pollination services underpinning the stability, structure and functioning of ecosystems. Amongst these threats, many synergistic drivers, such as habitat destruction and fragmentation, increasing use of agrochemicals, decreasing resource diversity, as well as climate change, are known to affect wild and managed
1 Register över enskilda arkiv vid Universitetsbiblioteket, Lunds universitet Juni 2014 Grått fält = restriktioner för arkivets tillgänglighet Omfattning anges i hyllmeter. Placering anges enligt intern kod. Bokstaven ”E” (i högerspalten) innebär att förteckning över arkivet finns i databasen EDIFFAH. 2 Universitetsbiblioteket, Lunds universitet Handskrifter och specialsamlingar ARKIVREGISTER A Na
https://www.ub.lu.se/en/sites/ub.lu.se.en/files/arkivregister-juni2014.pdf - 2025-08-31
1 Implementing environmentally conscious product development in the Canadian industries: an industrial design systemic perspective Master presented in the fulfilment of the LUMES program: Lund University international Masters program in Environmental Science By: Catherine Loriot 4648 rue Marquette Montréal (QC) H2J 3Y4 Canada Tel: (+1) 514 523 9401 Catherine.Loriot.823@student.lu.se Under the supe
https://www.lumes.lu.se/sites/lumes.lu.se/files/loriot_catherine.pdf - 2025-08-31
TT vt2021 1 Issue 10, Spring 2021 Letter from the Director of Studies What’s Brewing – Graduate School news & info New University Leadership – Interview with our previous Pro-Dean, Deputy Vice-Chancellor Lena Eskilsson Quality Assurance processes Vice-Chancellor’s Corona Report Graduate School Alumni Network Social Scientific Data Analysis programme – greeting from the Director Understanding the U
https://www.graduateschool.sam.lu.se/sites/graduateschool.sam.lu.se/files/2021-05/TT%20vt2021.pdf - 2025-08-31
otso_1 ! Women and Maids Perceptions of domestic workers, housework and class among young, progressive, middle- to upper-class women in Delhi Otso Harju* Working Paper No 55 2017 Centre for East and South-East Asian Studies Lund University, Sweden www.ace.lu.se * Otso Harju was a student on the Masters Programme in Asian Studies, Centre for East and South-East Asian Studies, Lund University betwee
https://www.sasnet.lu.se/sites/sasnet.lu.se/files/otsoharjuwomenandmaids.pdf - 2025-08-31
MISSION IS POSSIBLE MISSION IS POSSIBLE WORLD-LEADING RESEARCH THAT PROVIDES BENEFITS FOR OUR SOCIETY LUND UNIVERSITY| MISSION IS POSSIBLE WORLD-LEADING RESEARCH THAT PROVIDES BENEFITS FOR OUR SOCIETY | LUND UNIVERSITY World-leading research benefits our society Sweden has a knowledge-based economy. Our wealth and welfare are built upon the constant formulation of new, enriching ideas that improve
https://www.lunduniversity.lu.se/sites/www.lunduniversity.lu.se/files/2023-04/330927_Mission%20is%20possible_eng.pdf - 2025-08-31
Register över enskilda arkiv vid Universitetsbiblioteket, Lunds universitet Juni 2015 Grått fält = restriktioner för arkivets tillgänglighet Omfattning anges i hyllmeter. Placering anges enligt intern kod. Bokstaven ”E” (i högerspalten) innebär att förteckning över arkivet finns i databasen EDIFFAH. 1 Universitetsbiblioteket, Lunds universitet Handskrifter och specialsamlingar ARKIVREGISTER A Namn
https://www.ub.lu.se/en/sites/ub.lu.se.en/files/arkivregister_allt_juni_2015.pdf - 2025-08-31
LUM nr 10 - 2005 LUM Lunds universitets magasin | Nr 10 | 2005 ALLT LJUS PÅ KINA Slarv får bidrag att bränna inne Resistenta fåglar bekymrar forskare 2 LUM NR 10 | 2005 BRINN MÖSSA, BRINN! LUM NR 10 | 2005 3 Det finns få så symbolladdade år- tal under det förra seklet som 1968. Studentrevolten i Paris i maj, pro- testerna mot den sovjetkommunis- tiska modellen under Pragvåren, studentrevolten och
https://www.lu.se/sites/www.lu.se/files/lunds-universitets-magasin-10-2005.pdf - 2025-08-31
nr11 NYAST IS A € - BLOC EMERGING IN CENTRAL AND EASTERN EUROPE? Viktor Hjort Nils-Erik Strömbom No. 11 Is a € - Bloc Emerging in Central and Eastern Europe? Viktor Hjort Viktor.Hjort@msdw.com Nils-Erik Strömbom nist04@handelsbanken.se CENTRE FOR EUROPEAN STUDIES AT LUND UNIVERSITY: Box 52 Phone: +46 (0)46-222 88 99 SE-221 00 LUND Fax: +46 (0)46-222 40 06 Sweden Email: cfe@cfe.lu.se CFE Working pa
https://www.cfe.lu.se/en/sites/cfe.lu.se.en/files/2020-12/cfewp11.pdf - 2025-08-31
Dopamine Neuron Diversity: Recent Advances and Current Challenges in Human Stem Cell Models and Single Cell Sequencing cells Review Dopamine Neuron Diversity: Recent Advances and Current Challenges in Human Stem Cell Models and Single Cell Sequencing Alessandro Fiorenzano * , Edoardo Sozzi, Malin Parmar and Petter Storm Citation: Fiorenzano, A.; Sozzi, E.; Parmar, M.; Storm, P. Dopamine Neuron D
Neutralizing antibodies (inhibitors) toward factor VIII form a severe complication in nonsevere hemophilia A, profoundly aggravating the bleeding pattern. Identification of high-risk patients is hampered by lack of data that take exposure days to therapeutic factor VIII concentrates into account. In the INSIGHT study, we analyzed the association between F8 mutation and inhibitor development in pat
To identify susceptibility loci for classical Hodgkin's lymphoma (cHL), we conducted a genome-wide association study of 589 individuals with cHL (cases) and 5,199 controls with validation in four independent samples totaling 2,057 cases and 3,416 controls. We identified three new susceptibility loci at 2p16.1 (rs1432295, REL, odds ratio (OR) = 1.22, combined P = 1.91 x 10(-8)), 8q24.21 (rs2019960,
BACKGROUND: Treatment of newly diagnosed advanced-stage ovarian cancer typically involves cytoreductive surgery and systemic chemotherapy. We conducted a trial to investigate whether the addition of hyperthermic intraperitoneal chemotherapy (HIPEC) to interval cytoreductive surgery would improve outcomes among patients who were receiving neoadjuvant chemotherapy for stage III epithelial ovarian ca
